YKL013C / ARC19

Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL013C / ARC19

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:5.17|P-value:4.68E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:5.47|P-value:1.06E-7 ID:SGTC_57|Compound:miconazole|FD-Score:3.29|P-value:9.11E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:4.49|P-value:1.02E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:5.32|P-value:2.27E-7 ID:SGTC_246|Compound:cycloheximide|FD-Score:4.77|P-value:3.07E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:-3.87|P-value:1.21E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.85|P-value:1.31E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.47|P-value:4.99E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.71|P-value:2.20E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.44|P-value:5.53E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.51|P-value:9.39E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:3.99|P-value:7.58E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.64|P-value:2.82E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.26|P-value:2.63E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:16.40|P-value:1.31E-54 ID:SGTC_767|Compound:0929-0023|FD-Score:4.30|P-value:2.23E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.91|P-value:1.04E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:5.88|P-value:1.22E-8 ID:SGTC_852|Compound:0418-0143|FD-Score:5.08|P-value:7.18E-7 ID:SGTC_886|Compound:0866-0150|FD-Score:3.41|P-value:6.00E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.36|P-value:7.28E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.32|P-value:8.28E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.73|P-value:1.98E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.86|P-value:2.01E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.37|P-value:6.97E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.67|P-value:2.45E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:6.71|P-value:9.77E-11 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.11|P-value:4.92E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.27|P-value:9.75E-4 ID:SGTC_1635|Compound:st007035|FD-Score:8.83|P-value:2.63E-17 ID:SGTC_1636|Compound:st007707|FD-Score:7.10|P-value:8.13E-12 ID:SGTC_1764|Compound:st044502|FD-Score:3.61|P-value:3.12E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:8.70|P-value:7.65E-17 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.48|P-value:1.07E-5 ID:SGTC_1881|Compound:5652484|FD-Score:4.87|P-value:1.89E-6 ID:SGTC_1909|Compound:st060837|FD-Score:4.67|P-value:4.68E-6 ID:SGTC_2007|Compound:4011539|FD-Score:4.12|P-value:4.68E-5 ID:SGTC_2009|Compound:4012297|FD-Score:4.15|P-value:4.21E-5 ID:SGTC_2012|Compound:4023501|FD-Score:4.88|P-value:1.85E-6 ID:SGTC_2094|Compound:5332512|FD-Score:4.09|P-value:5.20E-5 ID:SGTC_2098|Compound:5376439|FD-Score:-4.61|P-value:5.94E-6 ID:SGTC_2255|Compound:7941087|FD-Score:5.76|P-value:2.35E-8 ID:SGTC_2283|Compound:7944793|FD-Score:3.39|P-value:6.47E-4 ID:SGTC_2286|Compound:7945697|FD-Score:7.29|P-value:2.39E-12 ID:SGTC_2366|Compound:9070441|FD-Score:3.85|P-value:1.28E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.40|P-value:6.38E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.54|P-value:3.88E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.53|P-value:4.08E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.34|P-value:7.77E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.70|P-value:2.22E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.06|P-value:5.78E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.90|P-value:1.08E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.48|P-value:4.84E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.41|P-value:1.42E-7 ID:SGTC_2935|Compound:9038016|FD-Score:7.15|P-value:6.03E-12 ID:SGTC_3119|Compound:9125183|FD-Score:4.08|P-value:5.45E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.43|P-value:5.63E-4 ID:SGTC_3303|Compound:9125618|FD-Score:7.39|P-value:1.18E-12 ID:SGTC_43|Compound:0570-0105|FD-Score:5.17|P-value:4.68E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:5.47|P-value:1.06E-7 ID:SGTC_57|Compound:miconazole|FD-Score:3.29|P-value:9.11E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:4.49|P-value:1.02E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:5.32|P-value:2.27E-7 ID:SGTC_246|Compound:cycloheximide|FD-Score:4.77|P-value:3.07E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:-3.87|P-value:1.21E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.85|P-value:1.31E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.47|P-value:4.99E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.71|P-value:2.20E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.44|P-value:5.53E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.51|P-value:9.39E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:3.99|P-value:7.58E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.64|P-value:2.82E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.26|P-value:2.63E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:16.40|P-value:1.31E-54 ID:SGTC_767|Compound:0929-0023|FD-Score:4.30|P-value:2.23E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.91|P-value:1.04E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:5.88|P-value:1.22E-8 ID:SGTC_852|Compound:0418-0143|FD-Score:5.08|P-value:7.18E-7 ID:SGTC_886|Compound:0866-0150|FD-Score:3.41|P-value:6.00E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.36|P-value:7.28E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.32|P-value:8.28E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.73|P-value:1.98E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.86|P-value:2.01E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.37|P-value:6.97E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.67|P-value:2.45E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:6.71|P-value:9.77E-11 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.11|P-value:4.92E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.27|P-value:9.75E-4 ID:SGTC_1635|Compound:st007035|FD-Score:8.83|P-value:2.63E-17 ID:SGTC_1636|Compound:st007707|FD-Score:7.10|P-value:8.13E-12 ID:SGTC_1764|Compound:st044502|FD-Score:3.61|P-value:3.12E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:8.70|P-value:7.65E-17 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.48|P-value:1.07E-5 ID:SGTC_1881|Compound:5652484|FD-Score:4.87|P-value:1.89E-6 ID:SGTC_1909|Compound:st060837|FD-Score:4.67|P-value:4.68E-6 ID:SGTC_2007|Compound:4011539|FD-Score:4.12|P-value:4.68E-5 ID:SGTC_2009|Compound:4012297|FD-Score:4.15|P-value:4.21E-5 ID:SGTC_2012|Compound:4023501|FD-Score:4.88|P-value:1.85E-6 ID:SGTC_2094|Compound:5332512|FD-Score:4.09|P-value:5.20E-5 ID:SGTC_2098|Compound:5376439|FD-Score:-4.61|P-value:5.94E-6 ID:SGTC_2255|Compound:7941087|FD-Score:5.76|P-value:2.35E-8 ID:SGTC_2283|Compound:7944793|FD-Score:3.39|P-value:6.47E-4 ID:SGTC_2286|Compound:7945697|FD-Score:7.29|P-value:2.39E-12 ID:SGTC_2366|Compound:9070441|FD-Score:3.85|P-value:1.28E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.40|P-value:6.38E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.54|P-value:3.88E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.53|P-value:4.08E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.34|P-value:7.77E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.70|P-value:2.22E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.06|P-value:5.78E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.90|P-value:1.08E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.48|P-value:4.84E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.41|P-value:1.42E-7 ID:SGTC_2935|Compound:9038016|FD-Score:7.15|P-value:6.03E-12 ID:SGTC_3119|Compound:9125183|FD-Score:4.08|P-value:5.45E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.43|P-value:5.63E-4 ID:SGTC_3303|Compound:9125618|FD-Score:7.39|P-value:1.18E-12

Top fitness defect scores for YKL013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_748 0136-0228 16.40 77.9 µM 1.31E-54 redox potentiating 2 1.96E-60 3.01
2 SGTC_1635 st007035 8.83 42.4 µM 2.63E-17 1 5.04E-19 1.66
3 SGTC_1872 amphotericin b 8.70 148.0 nM 7.65E-17 RNA pol III & RNase P/MRP 7 1.65E-18 0.43
4 SGTC_3303 9125618 7.39 40.6 µM 1.18E-12 2 7.33E-14 1.84
5 SGTC_2286 7945697 7.29 125.0 µM 2.39E-12 1 1.60E-13 1.73
6 SGTC_2935 9038016 7.15 30.0 µM 6.03E-12 2 4.45E-13 0.13
7 SGTC_1636 st007707 7.10 68.9 µM 8.13E-12 1 6.20E-13 1.01
8 SGTC_1482 3346-2049 6.71 8.5 µM 9.77E-11 1 9.76E-12 1.71
9 SGTC_849 0386-0493 5.88 241.0 µM 1.22E-8 2 2.06E-9 1.14
10 SGTC_2255 7941087 5.76 197.4 µM 2.35E-8 1 4.25E-9 1.13
11 SGTC_50 0929-0078 5.47 56.4 µM 1.06E-7 2 2.26E-8 0.76
12 SGTC_2920 7982904 5.41 15.8 µM 1.42E-7 3 3.12E-8 0.00
13 SGTC_192 3455-0609 5.32 60.9 µM 2.27E-7 2 5.23E-8 0.79
14 SGTC_43 0570-0105 5.17 72.5 µM 4.68E-7 ERG2 4 1.17E-7 0.18
15 SGTC_852 0418-0143 5.08 439.0 µM 7.18E-7 calcium & mitochondrial duress 5 1.88E-7 0.37
16 SGTC_2012 4023501 4.88 200.0 µM 1.85E-6 6 5.35E-7 0.40
17 SGTC_1881 5652484 4.87 16.0 µM 1.89E-6 TRP & mitochondrial translation 4 5.47E-7 0.89
18 SGTC_1189 1431-2119 4.86 7.3 µM 2.01E-6 6 5.87E-7 0.70
19 SGTC_246 cycloheximide 4.77 667.0 µM 3.07E-6 8 9.37E-7 0.70
20 SGTC_1909 st060837 4.67 51.5 µM 4.68E-6 6 1.49E-6 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.287 1.25E-64 YNR035C ARC35 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
0.217 3.45E-37 YJR065C ARP3 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.168 1.23E-22 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.162 5.75E-21 YDR276C PMP3 hom Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
0.161 5.50E-21 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.154 3.49E-19 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.152 1.02E-18 YKL041W VPS24 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
0.146 1.67E-17 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.143 8.07E-17 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.139 5.51E-16 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.137 1.48E-15 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.135 4.40E-15 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.134 5.81E-15 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.131 2.75E-14 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.131 3.19E-14 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization