YKL014C / URB1

Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL014C / URB1

Click on Significant Values for Screen Details ID:SGTC_557|Compound:1315-0110|FD-Score:-2.82|P-value:6.04E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.74|P-value:8.37E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.01|P-value:2.66E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.03|P-value:2.47E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.71|P-value:9.58E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:-4.49|P-value:1.23E-7 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.43|P-value:4.09E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:-2.89|P-value:4.41E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.37|P-value:5.12E-5 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:2.85|P-value:5.18E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.08|P-value:1.96E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.48|P-value:3.04E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-2.72|P-value:8.80E-4 ID:SGTC_1733|Compound:st037357|FD-Score:5.01|P-value:4.00E-9 ID:SGTC_1735|Compound:st034310|FD-Score:-3.76|P-value:7.57E-6 ID:SGTC_1747|Compound:st037496|FD-Score:2.98|P-value:3.05E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.16|P-value:1.39E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.70|P-value:9.37E-4 ID:SGTC_2444|Compound:5485484|FD-Score:2.94|P-value:3.61E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.16|P-value:1.34E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.21|P-value:1.09E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.88|P-value:4.60E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:2.87|P-value:4.80E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-2.71|P-value:9.05E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.98|P-value:2.33E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-3.20|P-value:1.16E-4 ID:SGTC_2848|Compound:9016370|FD-Score:2.70|P-value:9.25E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.44|P-value:3.75E-5 ID:SGTC_2999|Compound:9069765|FD-Score:2.94|P-value:3.56E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.23|P-value:1.04E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-2.82|P-value:6.04E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.74|P-value:8.37E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.01|P-value:2.66E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.03|P-value:2.47E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.71|P-value:9.58E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:-4.49|P-value:1.23E-7 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.43|P-value:4.09E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:-2.89|P-value:4.41E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.37|P-value:5.12E-5 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:2.85|P-value:5.18E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.08|P-value:1.96E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.48|P-value:3.04E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-2.72|P-value:8.80E-4 ID:SGTC_1733|Compound:st037357|FD-Score:5.01|P-value:4.00E-9 ID:SGTC_1735|Compound:st034310|FD-Score:-3.76|P-value:7.57E-6 ID:SGTC_1747|Compound:st037496|FD-Score:2.98|P-value:3.05E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.16|P-value:1.39E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.70|P-value:9.37E-4 ID:SGTC_2444|Compound:5485484|FD-Score:2.94|P-value:3.61E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.16|P-value:1.34E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.21|P-value:1.09E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.88|P-value:4.60E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:2.87|P-value:4.80E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-2.71|P-value:9.05E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.98|P-value:2.33E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-3.20|P-value:1.16E-4 ID:SGTC_2848|Compound:9016370|FD-Score:2.70|P-value:9.25E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.44|P-value:3.75E-5 ID:SGTC_2999|Compound:9069765|FD-Score:2.94|P-value:3.56E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.23|P-value:1.04E-4

Top fitness defect scores for YKL014C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1733 st037357 5.01 54.9 µM 4.00E-9 60S ribosome export 3 2.71E-7 0.87
2 SGTC_644 1498-1197 3.74 63.3 µM 8.37E-6 9 9.26E-5 0.22
3 SGTC_1411 3909-8223 3.71 150.0 µM 9.58E-6 1 1.03E-4 0.24
4 SGTC_1586 deoxycorticosterone acetate 3.48 53.7 µM 3.04E-5 3 2.49E-4 0.34
5 SGTC_2852 9023854 3.44 52.0 µM 3.75E-5 10 2.92E-4 0.02
6 SGTC_1472 k841-0093 3.37 193.0 µM 5.12E-5 3 3.71E-4 0.18
7 SGTC_2572 astragaloside iv 3.21 100.0 µM 1.09E-4 17 6.63E-4 0.04
8 SGTC_2473 5854593 3.16 8.9 µM 1.34E-4 7 7.77E-4 6.22E-4
9 SGTC_2094 5332512 3.16 191.7 µM 1.39E-4 12 8.00E-4 0.05
10 SGTC_1747 st037496 2.98 66.6 µM 3.05E-4 26 0.00146 0.01
11 SGTC_2999 9069765 2.94 71.4 µM 3.56E-4 amide catabolism 11 0.00165 0.03
12 SGTC_2444 5485484 2.94 36.4 µM 3.61E-4 25 0.00167 0.04
13 SGTC_2602 kawain 2.88 100.0 µM 4.60E-4 11 0.00201 0.01
14 SGTC_2689 tacrolimus 2.87 100.0 µM 4.80E-4 29 0.00207 0.10
15 SGTC_1560 lithocholic acid 2.85 53.1 µM 5.18E-4 8 0.00220 0.14
16 SGTC_2848 9016370 2.70 26.0 µM 9.25E-4 14 0.00343 0.08
17 SGTC_2354 9060492 2.70 162.0 µM 9.37E-4 18 0.00347 0.11
18 SGTC_253 dyclonine 2.68 31.2 µM 0.00101 amide catabolism 25 0.00368 0.03
19 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 2.65 19.1 µM 0.00113 19 0.00400 0.03
20 SGTC_502 l-744,832 2.64 89.3 µM 0.00116 calcium & mitochondrial duress 15 0.00409 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.16E-14 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.103 2.13E-9 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.103 2.26E-9 YOR325W_d YOR325W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1
0.102 2.73E-9 YGR210C_p YGR210C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.102 3.09E-9 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.094 5.39E-8 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.091 1.28E-7 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.089 2.10E-7 YOL126C MDH2 hom Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
0.088 3.51E-7 YAL020C ATS1 hom Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
0.085 9.61E-7 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.085 8.96E-7 YPL003W ULA1 hom Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
0.084 1.19E-6 YLR251W SYM1 hom Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
0.083 1.31E-6 YPR150W_d YPR150W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
0.079 4.11E-6 YJL112W MDV1 hom Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication
0.076 1.02E-5 YHR039C MSC7 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids