YKL018C-A_p

Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL018C-A / YKL018C-A

Click on Significant Values for Screen Details ID:SGTC_112|Compound:phenothiazine|FD-Score:2.78|P-value:8.44E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.10|P-value:2.35E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.77|P-value:1.06E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.97|P-value:3.75E-6 ID:SGTC_508|Compound:roscovitine|FD-Score:4.03|P-value:2.76E-6 ID:SGTC_509|Compound:pifithrin|FD-Score:4.32|P-value:5.35E-7 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.09|P-value:2.40E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.03|P-value:3.13E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.40|P-value:6.16E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:2.94|P-value:4.54E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.79|P-value:8.16E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.39|P-value:6.65E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.32|P-value:8.80E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.60|P-value:2.47E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:-2.89|P-value:5.55E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.12|P-value:2.14E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.51|P-value:1.78E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-5.90|P-value:1.29E-11 ID:SGTC_1744|Compound:st037937|FD-Score:2.81|P-value:7.71E-4 ID:SGTC_1864|Compound:st057645|FD-Score:-2.79|P-value:8.20E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-2.85|P-value:6.38E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.79|P-value:3.24E-8 ID:SGTC_2342|Compound:7990637|FD-Score:-6.10|P-value:2.91E-12 ID:SGTC_2344|Compound:7990960|FD-Score:5.73|P-value:5.01E-11 ID:SGTC_2351|Compound:9026858|FD-Score:-3.84|P-value:7.21E-6 ID:SGTC_2375|Compound:9072683|FD-Score:2.78|P-value:8.47E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.03|P-value:3.05E-4 ID:SGTC_2442|Compound:5158906|FD-Score:2.82|P-value:7.44E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.79|P-value:8.32E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.52|P-value:3.62E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.44|P-value:5.12E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.10|P-value:2.32E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.12|P-value:2.19E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.95|P-value:4.16E-6 ID:SGTC_2704|Compound:st078022|FD-Score:2.75|P-value:9.46E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-2.75|P-value:9.63E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-4.24|P-value:8.30E-7 ID:SGTC_2789|Compound:5281112|FD-Score:-3.08|P-value:2.54E-4 ID:SGTC_2873|Compound:9040596|FD-Score:5.37|P-value:6.75E-10 ID:SGTC_2874|Compound:9043904|FD-Score:3.81|P-value:8.49E-6 ID:SGTC_3101|Compound:9120531|FD-Score:2.83|P-value:6.97E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.07|P-value:2.68E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.09|P-value:2.46E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:2.78|P-value:8.44E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.10|P-value:2.35E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.77|P-value:1.06E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.97|P-value:3.75E-6 ID:SGTC_508|Compound:roscovitine|FD-Score:4.03|P-value:2.76E-6 ID:SGTC_509|Compound:pifithrin|FD-Score:4.32|P-value:5.35E-7 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.09|P-value:2.40E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.03|P-value:3.13E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.40|P-value:6.16E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:2.94|P-value:4.54E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.79|P-value:8.16E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.39|P-value:6.65E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.32|P-value:8.80E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.60|P-value:2.47E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:-2.89|P-value:5.55E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.12|P-value:2.14E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.51|P-value:1.78E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-5.90|P-value:1.29E-11 ID:SGTC_1744|Compound:st037937|FD-Score:2.81|P-value:7.71E-4 ID:SGTC_1864|Compound:st057645|FD-Score:-2.79|P-value:8.20E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-2.85|P-value:6.38E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.79|P-value:3.24E-8 ID:SGTC_2342|Compound:7990637|FD-Score:-6.10|P-value:2.91E-12 ID:SGTC_2344|Compound:7990960|FD-Score:5.73|P-value:5.01E-11 ID:SGTC_2351|Compound:9026858|FD-Score:-3.84|P-value:7.21E-6 ID:SGTC_2375|Compound:9072683|FD-Score:2.78|P-value:8.47E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.03|P-value:3.05E-4 ID:SGTC_2442|Compound:5158906|FD-Score:2.82|P-value:7.44E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.79|P-value:8.32E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.52|P-value:3.62E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.44|P-value:5.12E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.10|P-value:2.32E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.12|P-value:2.19E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.95|P-value:4.16E-6 ID:SGTC_2704|Compound:st078022|FD-Score:2.75|P-value:9.46E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-2.75|P-value:9.63E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-4.24|P-value:8.30E-7 ID:SGTC_2789|Compound:5281112|FD-Score:-3.08|P-value:2.54E-4 ID:SGTC_2873|Compound:9040596|FD-Score:5.37|P-value:6.75E-10 ID:SGTC_2874|Compound:9043904|FD-Score:3.81|P-value:8.49E-6 ID:SGTC_3101|Compound:9120531|FD-Score:2.83|P-value:6.97E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.07|P-value:2.68E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.09|P-value:2.46E-4

Top fitness defect scores for YKL018C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2344 7990960 5.73 77.0 µM 5.01E-11 8 5.07E-9
2 SGTC_2873 9040596 5.37 71.4 µM 6.75E-10 19 3.95E-8
3 SGTC_1716 st033144 4.51 30.6 µM 1.78E-7 12 3.24E-6
4 SGTC_509 pifithrin 4.32 175.0 µM 5.35E-7 mitochondrial processes 3 7.74E-6
5 SGTC_508 roscovitine 4.03 141.0 µM 2.76E-6 5 2.84E-5
6 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.97 150.0 µM 3.75E-6 Golgi 41 3.63E-5
7 SGTC_2698 st077697 3.95 67.5 µM 4.16E-6 17 3.93E-5
8 SGTC_2874 9043904 3.81 71.4 µM 8.49E-6 16 6.93E-5
9 SGTC_358 0075-0058 3.77 9.4 µM 1.06E-5 68 8.29E-5
10 SGTC_982 1491-0518 3.60 27.5 µM 2.47E-5 23 1.62E-4
11 SGTC_2491 paeonol 3.52 100.0 µM 3.62E-5 14 2.19E-4
12 SGTC_2492 derrusnin 3.44 100.0 µM 5.12E-5 11 2.89E-4
13 SGTC_882 0843-0131 3.39 351.0 µM 6.65E-5 30 3.56E-4
14 SGTC_975 1335-0046 3.32 28.5 µM 8.80E-5 RPP1 & pyrimidine depletion 65 4.44E-4
15 SGTC_2568 diosmetin 3.12 100.0 µM 2.19E-4 62 9.19E-4
16 SGTC_2493 resveratrol 3.10 26.1 µM 2.32E-4 27 9.61E-4
17 SGTC_236 1509-0011 3.10 5.3 µM 2.35E-4 452 9.72E-4
18 SGTC_3354 9151612 3.09 71.4 µM 2.46E-4 43 0.00101
19 SGTC_3200 9114385 3.07 49.5 µM 2.68E-4 86 0.00108
20 SGTC_543 3844-1095 3.03 191.0 µM 3.13E-4 ERG2 94 0.00122

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.98E-22 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.149 3.50E-18 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.141 1.90E-16 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.140 3.69E-16 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.134 6.92E-15 YLR098C CHA4 hom DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
0.132 1.33E-14 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.130 4.59E-14 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.130 4.79E-14 YBR149W ARA1 hom NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
0.129 5.36E-14 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.118 7.73E-12 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.114 3.30E-11 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.114 3.43E-11 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.113 4.71E-11 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.113 4.98E-11 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.107 4.31E-10 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex