YKL018W / SWD2

Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL018W / SWD2

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.28|P-value:3.76E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.00|P-value:9.89E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-6.27|P-value:1.98E-10 ID:SGTC_131|Compound:0141-0277|FD-Score:3.46|P-value:1.92E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.48|P-value:1.72E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.51|P-value:9.46E-9 ID:SGTC_141|Compound:0443-0274|FD-Score:5.51|P-value:9.57E-9 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.80|P-value:4.83E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:-5.61|P-value:1.15E-8 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.35|P-value:4.65E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.07|P-value:7.94E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.14|P-value:6.13E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.41|P-value:2.32E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.39|P-value:2.46E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.22|P-value:7.82E-6 ID:SGTC_593|Compound:1203-0218|FD-Score:3.52|P-value:1.47E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.15|P-value:5.83E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.14|P-value:6.16E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.47|P-value:1.79E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.53|P-value:2.39E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.55|P-value:7.62E-9 ID:SGTC_889|Compound:0919-1524|FD-Score:4.36|P-value:4.11E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:3.43|P-value:2.14E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.49|P-value:1.68E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.07|P-value:7.70E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.56|P-value:1.28E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.00|P-value:2.06E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.25|P-value:6.60E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-3.93|P-value:4.94E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.69|P-value:8.03E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.26|P-value:6.34E-6 ID:SGTC_1518|Compound:st038567|FD-Score:-4.85|P-value:7.09E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.83|P-value:4.30E-5 ID:SGTC_1626|Compound:st003712|FD-Score:4.40|P-value:3.43E-6 ID:SGTC_1642|Compound:st009582|FD-Score:4.10|P-value:1.36E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.25|P-value:6.80E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.38|P-value:2.58E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.83|P-value:4.26E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.14|P-value:6.08E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.64|P-value:9.22E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.13|P-value:6.27E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.45|P-value:3.30E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.86|P-value:3.36E-7 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.43|P-value:2.11E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.71|P-value:6.96E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-5.82|P-value:3.31E-9 ID:SGTC_2797|Compound:7859098|FD-Score:5.60|P-value:5.47E-9 ID:SGTC_2798|Compound:7813637|FD-Score:4.59|P-value:1.35E-6 ID:SGTC_2799|Compound:7812892|FD-Score:4.65|P-value:9.93E-7 ID:SGTC_2839|Compound:9003951|FD-Score:3.08|P-value:7.46E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.79|P-value:5.04E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-4.08|P-value:2.65E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.31|P-value:5.35E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.28|P-value:6.12E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.21|P-value:7.76E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.28|P-value:3.76E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.00|P-value:9.89E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-6.27|P-value:1.98E-10 ID:SGTC_131|Compound:0141-0277|FD-Score:3.46|P-value:1.92E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.48|P-value:1.72E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.51|P-value:9.46E-9 ID:SGTC_141|Compound:0443-0274|FD-Score:5.51|P-value:9.57E-9 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.80|P-value:4.83E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:-5.61|P-value:1.15E-8 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.35|P-value:4.65E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.07|P-value:7.94E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.14|P-value:6.13E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.41|P-value:2.32E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.39|P-value:2.46E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.22|P-value:7.82E-6 ID:SGTC_593|Compound:1203-0218|FD-Score:3.52|P-value:1.47E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.15|P-value:5.83E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.14|P-value:6.16E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.47|P-value:1.79E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.53|P-value:2.39E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.55|P-value:7.62E-9 ID:SGTC_889|Compound:0919-1524|FD-Score:4.36|P-value:4.11E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:3.43|P-value:2.14E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.49|P-value:1.68E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.07|P-value:7.70E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.56|P-value:1.28E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.00|P-value:2.06E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.25|P-value:6.60E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-3.93|P-value:4.94E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.69|P-value:8.03E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.26|P-value:6.34E-6 ID:SGTC_1518|Compound:st038567|FD-Score:-4.85|P-value:7.09E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.83|P-value:4.30E-5 ID:SGTC_1626|Compound:st003712|FD-Score:4.40|P-value:3.43E-6 ID:SGTC_1642|Compound:st009582|FD-Score:4.10|P-value:1.36E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.25|P-value:6.80E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.38|P-value:2.58E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.83|P-value:4.26E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.14|P-value:6.08E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.64|P-value:9.22E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.13|P-value:6.27E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.45|P-value:3.30E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.86|P-value:3.36E-7 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.43|P-value:2.11E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.71|P-value:6.96E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-5.82|P-value:3.31E-9 ID:SGTC_2797|Compound:7859098|FD-Score:5.60|P-value:5.47E-9 ID:SGTC_2798|Compound:7813637|FD-Score:4.59|P-value:1.35E-6 ID:SGTC_2799|Compound:7812892|FD-Score:4.65|P-value:9.93E-7 ID:SGTC_2839|Compound:9003951|FD-Score:3.08|P-value:7.46E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.79|P-value:5.04E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-4.08|P-value:2.65E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.31|P-value:5.35E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.28|P-value:6.12E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.21|P-value:7.76E-4

Top fitness defect scores for YKL018W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2797 7859098 5.60 81.8 µM 5.47E-9 2 1.05E-8 0.73
2 SGTC_887 0885-0007 5.55 9.6 µM 7.62E-9 endomembrane recycling 8 1.45E-8 0.77
3 SGTC_137 0438-0332 5.51 85.4 µM 9.46E-9 ubiquinone biosynthesis & proteasome 21 1.79E-8 0.12
4 SGTC_141 0443-0274 5.51 32.3 µM 9.57E-9 mitochondrial response to ROS 2 1.81E-8 1.17
5 SGTC_2620 irigenin 4.86 100.0 µM 3.36E-7 6 5.78E-7 0.19
6 SGTC_1381 2324-0066 4.69 62.1 µM 8.03E-7 4 1.35E-6 0.33
7 SGTC_2799 7812892 4.65 81.8 µM 9.93E-7 superoxide 12 1.66E-6 0.23
8 SGTC_2798 7813637 4.59 45.5 µM 1.35E-6 9 2.23E-6 0.03
9 SGTC_1626 st003712 4.40 1.8 µM 3.43E-6 7 5.54E-6 0.50
10 SGTC_889 0919-1524 4.36 82.7 µM 4.11E-6 2 6.60E-6 0.57
11 SGTC_1508 1080-0625 4.26 72.9 µM 6.34E-6 1 1.00E-5 0.42
12 SGTC_584 0986-0246 4.22 15.4 µM 7.82E-6 heme requiring 21 1.23E-5 0.00
13 SGTC_1642 st009582 4.10 77.7 µM 1.36E-5 RPP1 & pyrimidine depletion 7 2.11E-5 0.34
14 SGTC_1059 3448-6867 4.00 171.0 µM 2.06E-5 3 3.15E-5 0.06
15 SGTC_2058 5236698 3.83 133.0 µM 4.26E-5 5 6.38E-5 0.19
16 SGTC_1525 8-methoxypsoralen 3.83 92.5 µM 4.30E-5 DNA damage response 15 6.44E-5 0.19
17 SGTC_275 trichlorophene 3.80 5.7 µM 4.83E-5 mitochondrial stress 4 7.20E-5 0.18
18 SGTC_2932 9016711 3.79 44.5 µM 5.04E-5 11 7.52E-5 0.13
19 SGTC_2709 st078560 3.71 56.0 µM 6.96E-5 8 1.03E-4 0.29
20 SGTC_2346 9031566 3.64 143.8 µM 9.22E-5 Golgi 14 1.35E-4 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.02E-13 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.114 3.35E-11 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.098 1.11E-8 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.098 1.33E-8 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.094 5.16E-8 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.093 7.23E-8 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.091 1.36E-7 YCR021C HSP30 hom Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
0.090 1.99E-7 YOR336W KRE5 het Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
0.088 3.16E-7 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.087 5.07E-7 YOR339C UBC11 hom Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
0.085 7.30E-7 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.084 1.24E-6 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.67E-6 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.081 2.41E-6 YOR157C PUP1 het Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
0.081 2.91E-6 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1