YKL022C / CDC16

Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL022C / CDC16

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-3.75|P-value:3.07E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:-4.03|P-value:5.72E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:3.02|P-value:1.15E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:5.65|P-value:3.03E-12 ID:SGTC_156|Compound:3474-0145|FD-Score:3.92|P-value:8.79E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.52|P-value:1.09E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.71|P-value:3.77E-6 ID:SGTC_447|Compound:ml7|FD-Score:2.74|P-value:4.15E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.76|P-value:3.69E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-2.73|P-value:5.07E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.14|P-value:6.34E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:2.86|P-value:2.39E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.51|P-value:9.43E-6 ID:SGTC_597|Compound:k018-0003|FD-Score:3.24|P-value:3.81E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.70|P-value:5.74E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.92|P-value:2.14E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.71|P-value:5.50E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-2.73|P-value:5.19E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.03|P-value:6.45E-10 ID:SGTC_761|Compound:k216-0224|FD-Score:3.19|P-value:4.92E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:2.77|P-value:3.51E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.11|P-value:7.22E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.25|P-value:4.60E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:2.98|P-value:1.39E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:2.56|P-value:8.94E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:-2.78|P-value:4.09E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.26|P-value:4.29E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.13|P-value:2.45E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:-5.76|P-value:1.67E-12 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.58|P-value:1.18E-8 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-2.61|P-value:8.31E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.88|P-value:1.42E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.75|P-value:3.60E-9 ID:SGTC_1136|Compound:pergolide|FD-Score:6.42|P-value:2.81E-15 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.39|P-value:1.77E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:2.82|P-value:2.83E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.27|P-value:1.29E-7 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.57|P-value:8.46E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:2.91|P-value:1.94E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-2.58|P-value:9.41E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-2.64|P-value:7.29E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.27|P-value:3.37E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.49|P-value:1.04E-5 ID:SGTC_1746|Compound:st038117|FD-Score:5.54|P-value:8.10E-12 ID:SGTC_1766|Compound:st045414|FD-Score:-3.77|P-value:2.69E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.85|P-value:3.06E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.03|P-value:1.11E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-2.91|P-value:2.28E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.47|P-value:1.17E-5 ID:SGTC_2305|Compound:7443522|FD-Score:2.79|P-value:3.32E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.71|P-value:3.03E-6 ID:SGTC_2340|Compound:7987427|FD-Score:2.91|P-value:1.92E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.70|P-value:3.95E-6 ID:SGTC_2349|Compound:9023730|FD-Score:2.79|P-value:3.21E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.16|P-value:5.84E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-3.05|P-value:1.18E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.70|P-value:4.95E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.13|P-value:6.69E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.90|P-value:5.21E-13 ID:SGTC_2706|Compound:st078239|FD-Score:-2.82|P-value:3.47E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-2.57|P-value:9.86E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.03|P-value:1.09E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.12|P-value:6.86E-5 ID:SGTC_3312|Compound:9133330|FD-Score:2.83|P-value:2.71E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.32|P-value:2.51E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.00|P-value:1.24E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.20|P-value:5.80E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.75|P-value:3.07E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:-4.03|P-value:5.72E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:3.02|P-value:1.15E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:5.65|P-value:3.03E-12 ID:SGTC_156|Compound:3474-0145|FD-Score:3.92|P-value:8.79E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.52|P-value:1.09E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.71|P-value:3.77E-6 ID:SGTC_447|Compound:ml7|FD-Score:2.74|P-value:4.15E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.76|P-value:3.69E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-2.73|P-value:5.07E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.14|P-value:6.34E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:2.86|P-value:2.39E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.51|P-value:9.43E-6 ID:SGTC_597|Compound:k018-0003|FD-Score:3.24|P-value:3.81E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.70|P-value:5.74E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.92|P-value:2.14E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.71|P-value:5.50E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-2.73|P-value:5.19E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.03|P-value:6.45E-10 ID:SGTC_761|Compound:k216-0224|FD-Score:3.19|P-value:4.92E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:2.77|P-value:3.51E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.11|P-value:7.22E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.25|P-value:4.60E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:2.98|P-value:1.39E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:2.56|P-value:8.94E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:-2.78|P-value:4.09E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.26|P-value:4.29E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.13|P-value:2.45E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:-5.76|P-value:1.67E-12 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.58|P-value:1.18E-8 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-2.61|P-value:8.31E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.88|P-value:1.42E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.75|P-value:3.60E-9 ID:SGTC_1136|Compound:pergolide|FD-Score:6.42|P-value:2.81E-15 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.39|P-value:1.77E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:2.82|P-value:2.83E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.27|P-value:1.29E-7 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.57|P-value:8.46E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:2.91|P-value:1.94E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-2.58|P-value:9.41E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-2.64|P-value:7.29E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.27|P-value:3.37E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.49|P-value:1.04E-5 ID:SGTC_1746|Compound:st038117|FD-Score:5.54|P-value:8.10E-12 ID:SGTC_1766|Compound:st045414|FD-Score:-3.77|P-value:2.69E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.85|P-value:3.06E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.03|P-value:1.11E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-2.91|P-value:2.28E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.47|P-value:1.17E-5 ID:SGTC_2305|Compound:7443522|FD-Score:2.79|P-value:3.32E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.71|P-value:3.03E-6 ID:SGTC_2340|Compound:7987427|FD-Score:2.91|P-value:1.92E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.70|P-value:3.95E-6 ID:SGTC_2349|Compound:9023730|FD-Score:2.79|P-value:3.21E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.16|P-value:5.84E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-3.05|P-value:1.18E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.70|P-value:4.95E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.13|P-value:6.69E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.90|P-value:5.21E-13 ID:SGTC_2706|Compound:st078239|FD-Score:-2.82|P-value:3.47E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-2.57|P-value:9.86E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.03|P-value:1.09E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.12|P-value:6.86E-5 ID:SGTC_3312|Compound:9133330|FD-Score:2.83|P-value:2.71E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.32|P-value:2.51E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.00|P-value:1.24E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.20|P-value:5.80E-5

Top fitness defect scores for YKL022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1136 pergolide 6.42 1.1 µM 2.81E-15 4 6.68E-11 0.70
2 SGTC_155 k072-0202 5.65 43.6 µM 3.03E-12 3 7.91E-9 1.66
3 SGTC_1746 st038117 5.54 42.0 µM 8.10E-12 2 1.55E-8 0.68
4 SGTC_1135 dihydrocapsaicin 4.75 536.7 nM 3.60E-9 3 1.01E-6 0.49
5 SGTC_1125 tnp00248 4.58 1.3 µM 1.18E-8 6 2.27E-6 0.47
6 SGTC_1122 capsaicin 4.13 818.6 nM 2.45E-7 2 1.83E-5 0.03
7 SGTC_156 3474-0145 3.92 5.6 µM 8.79E-7 endomembrane recycling 6 4.40E-5 0.01
8 SGTC_2310 7668677 3.71 200.0 µM 3.03E-6 7 1.03E-4 0.16
9 SGTC_592 k241-0073 3.51 46.5 µM 9.43E-6 5 2.26E-4 0.25
10 SGTC_1742 st038235 3.49 28.9 µM 1.04E-5 mitochondrial stress 12 2.42E-4 0.08
11 SGTC_2281 7943571 3.47 200.0 µM 1.17E-5 8 2.61E-4 0.01
12 SGTC_1211 1056-0033 3.39 32.3 µM 1.77E-5 7 3.49E-4 0.03
13 SGTC_3313 9133968 3.32 57.0 µM 2.51E-5 2 4.44E-4 0.05
14 SGTC_1312 1218-2183 3.27 165.0 µM 3.37E-5 4 5.44E-4 0.08
15 SGTC_597 k018-0003 3.24 82.8 µM 3.81E-5 RNA pol III & RNase P/MRP 9 5.92E-4 7.09E-4
16 SGTC_761 k216-0224 3.19 480.0 µM 4.92E-5 15 7.06E-4 0.05
17 SGTC_2408 sulbentine 3.16 18.4 µM 5.84E-5 54 7.96E-4 0.01
18 SGTC_549 1661-1316 3.14 519.0 µM 6.34E-5 14 8.42E-4 0.10
19 SGTC_2621 lithochol-11-enic acid 3.13 100.0 µM 6.69E-5 16 8.75E-4 0.02
20 SGTC_3215 9129942 3.12 49.5 µM 6.86E-5 17 8.90E-4 0.16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 8.87E-33 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.178 2.30E-25 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.172 1.42E-23 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.168 1.47E-22 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.167 2.45E-22 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.165 6.56E-22 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.156 1.19E-19 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.155 1.46E-19 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.151 1.36E-18 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.150 2.06E-18 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.148 6.62E-18 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.145 3.15E-17 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.143 6.92E-17 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.143 9.44E-17 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.139 7.20E-16 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data