YKL023W_p

Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL023W / YKL023W

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:-3.67|P-value:6.11E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.29|P-value:2.52E-11 ID:SGTC_103|Compound:0844-0104|FD-Score:3.95|P-value:1.85E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.57|P-value:9.19E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.40|P-value:1.84E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:6.23|P-value:3.98E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.08|P-value:6.21E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.42|P-value:1.79E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.04|P-value:7.57E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.08|P-value:6.59E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.17|P-value:4.63E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:2.98|P-value:9.43E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.71|P-value:5.48E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:3.57|P-value:9.62E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.43|P-value:1.74E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.83|P-value:3.09E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:3.45|P-value:1.61E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.84|P-value:3.05E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:4.36|P-value:2.68E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.41|P-value:1.83E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.07|P-value:6.02E-8 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.03|P-value:7.86E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:5.16|P-value:3.65E-8 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.02|P-value:7.75E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.22|P-value:3.93E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.32|P-value:2.66E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:4.24|P-value:4.91E-6 ID:SGTC_1606|Compound:st000094|FD-Score:3.33|P-value:2.56E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.96|P-value:1.80E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.42|P-value:1.78E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.04|P-value:7.66E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.31|P-value:2.78E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.56|P-value:1.02E-4 ID:SGTC_1916|Compound:st067606|FD-Score:7.00|P-value:1.39E-13 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:5.24|P-value:2.28E-8 ID:SGTC_2105|Compound:5350118|FD-Score:3.55|P-value:1.07E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.11|P-value:5.71E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.16|P-value:4.78E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.80|P-value:3.65E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.38|P-value:1.98E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.16|P-value:4.95E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.30|P-value:2.87E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.43|P-value:1.64E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.01|P-value:8.52E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.01|P-value:8.49E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.32|P-value:2.70E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:-3.05|P-value:7.10E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.10|P-value:6.11E-4 ID:SGTC_2874|Compound:9043904|FD-Score:4.39|P-value:2.26E-6 ID:SGTC_2931|Compound:9014674|FD-Score:3.38|P-value:2.08E-4 ID:SGTC_3006|Compound:9075424|FD-Score:4.45|P-value:1.69E-6 ID:SGTC_3013|Compound:9080133|FD-Score:5.17|P-value:3.30E-8 ID:SGTC_3015|Compound:9080845|FD-Score:3.35|P-value:2.35E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.16|P-value:4.81E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.52|P-value:1.21E-4 ID:SGTC_3067|Compound:9117431|FD-Score:2.97|P-value:9.73E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.41|P-value:1.83E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-4.06|P-value:1.07E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.96|P-value:1.77E-5 ID:SGTC_3205|Compound:9113483|FD-Score:5.54|P-value:3.57E-9 ID:SGTC_3244|Compound:9134489|FD-Score:3.57|P-value:9.94E-5 ID:SGTC_3260|Compound:9137109|FD-Score:-3.19|P-value:4.18E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.27|P-value:3.16E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.74|P-value:4.68E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.67|P-value:6.11E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.29|P-value:2.52E-11 ID:SGTC_103|Compound:0844-0104|FD-Score:3.95|P-value:1.85E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.57|P-value:9.19E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.40|P-value:1.84E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:6.23|P-value:3.98E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.08|P-value:6.21E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.42|P-value:1.79E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.04|P-value:7.57E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.08|P-value:6.59E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.17|P-value:4.63E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:2.98|P-value:9.43E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.71|P-value:5.48E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:3.57|P-value:9.62E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.43|P-value:1.74E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.83|P-value:3.09E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:3.45|P-value:1.61E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.84|P-value:3.05E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:4.36|P-value:2.68E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.41|P-value:1.83E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.07|P-value:6.02E-8 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.03|P-value:7.86E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:5.16|P-value:3.65E-8 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.02|P-value:7.75E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.22|P-value:3.93E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.32|P-value:2.66E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:4.24|P-value:4.91E-6 ID:SGTC_1606|Compound:st000094|FD-Score:3.33|P-value:2.56E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.96|P-value:1.80E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.42|P-value:1.78E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.04|P-value:7.66E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.31|P-value:2.78E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.56|P-value:1.02E-4 ID:SGTC_1916|Compound:st067606|FD-Score:7.00|P-value:1.39E-13 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:5.24|P-value:2.28E-8 ID:SGTC_2105|Compound:5350118|FD-Score:3.55|P-value:1.07E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.11|P-value:5.71E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.16|P-value:4.78E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.80|P-value:3.65E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.38|P-value:1.98E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.16|P-value:4.95E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.30|P-value:2.87E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.43|P-value:1.64E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.01|P-value:8.52E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.01|P-value:8.49E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.32|P-value:2.70E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:-3.05|P-value:7.10E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.10|P-value:6.11E-4 ID:SGTC_2874|Compound:9043904|FD-Score:4.39|P-value:2.26E-6 ID:SGTC_2931|Compound:9014674|FD-Score:3.38|P-value:2.08E-4 ID:SGTC_3006|Compound:9075424|FD-Score:4.45|P-value:1.69E-6 ID:SGTC_3013|Compound:9080133|FD-Score:5.17|P-value:3.30E-8 ID:SGTC_3015|Compound:9080845|FD-Score:3.35|P-value:2.35E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.16|P-value:4.81E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.52|P-value:1.21E-4 ID:SGTC_3067|Compound:9117431|FD-Score:2.97|P-value:9.73E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.41|P-value:1.83E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-4.06|P-value:1.07E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.96|P-value:1.77E-5 ID:SGTC_3205|Compound:9113483|FD-Score:5.54|P-value:3.57E-9 ID:SGTC_3244|Compound:9134489|FD-Score:3.57|P-value:9.94E-5 ID:SGTC_3260|Compound:9137109|FD-Score:-3.19|P-value:4.18E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.27|P-value:3.16E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.74|P-value:4.68E-5

Top fitness defect scores for YKL023W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1916 st067606 7.00 49.2 µM 1.39E-13 4 1.32E-12
2 SGTC_58 0957-0393 6.29 9.0 µM 2.52E-11 cell wall 195 1.56E-10
3 SGTC_416 estradiol valerate 6.23 100.0 µM 3.98E-11 1 2.38E-10
4 SGTC_3205 9113483 5.54 49.5 µM 3.57E-9 6 1.48E-8
5 SGTC_2091 4-phenylthiadiazole 5.24 200.0 µM 2.28E-8 3 8.14E-8
6 SGTC_3013 9080133 5.17 71.4 µM 3.30E-8 4 1.14E-7
7 SGTC_1236 0330-0013 5.16 258.0 µM 3.65E-8 2 1.25E-7
8 SGTC_1159 4092-0538 5.07 61.2 µM 6.02E-8 10 1.98E-7
9 SGTC_3006 9075424 4.45 71.4 µM 1.69E-6 6 4.27E-6
10 SGTC_2874 9043904 4.39 71.4 µM 2.26E-6 5 5.56E-6
11 SGTC_1138 3761-0006 4.36 1.0 µM 2.68E-6 2 6.51E-6
12 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 4.24 85.4 µM 4.91E-6 17 1.14E-5
13 SGTC_3192 9110362 3.96 49.5 µM 1.77E-5 mitochondrial processes 13 3.70E-5
14 SGTC_1786 berberine 3.96 21.6 µM 1.80E-5 60S ribosome export 31 3.77E-5
15 SGTC_103 0844-0104 3.95 51.8 µM 1.85E-5 ERAD & cell cycle 145 3.86E-5
16 SGTC_939 1165-0479 3.84 45.3 µM 3.05E-5 29 6.10E-5
17 SGTC_2562 3',7'-dimethoxyflavone 3.80 64.9 µM 3.65E-5 36 7.21E-5
18 SGTC_3286 9117135 3.74 37.2 µM 4.68E-5 20 9.06E-5
19 SGTC_712 r015-0009 3.71 80.6 µM 5.48E-5 24 1.05E-4
20 SGTC_747 3448-8087 3.57 38.7 µM 9.62E-5 36 1.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.26E-21 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.157 5.05E-20 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.155 1.64E-19 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.153 5.43E-19 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.149 4.41E-18 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.139 7.45E-16 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.123 8.55E-13 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.123 9.95E-13 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.121 2.33E-12 YGL217C_d YGL217C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W
0.118 5.80E-12 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.118 6.75E-12 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.116 1.77E-11 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.114 3.21E-11 YPR097W YPR097W hom Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111 1.05E-10 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.108 3.55E-10 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi