YKL024C / URA6

Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL024C / URA6

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-5.22|P-value:6.73E-9 ID:SGTC_79|Compound:0052-0007|FD-Score:3.05|P-value:4.03E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.78|P-value:8.12E-14 ID:SGTC_152|Compound:4469-0003|FD-Score:3.42|P-value:8.66E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.16|P-value:3.10E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.19|P-value:2.28E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:2.90|P-value:7.20E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.02|P-value:4.55E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.33|P-value:1.30E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.80|P-value:1.84E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.63|P-value:3.45E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.07|P-value:3.73E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.13|P-value:3.00E-6 ID:SGTC_1410|Compound:3909-8106|FD-Score:2.83|P-value:9.26E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.38|P-value:1.03E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.16|P-value:2.99E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.25|P-value:1.79E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-3.99|P-value:7.27E-6 ID:SGTC_2132|Compound:5317594|FD-Score:2.88|P-value:7.90E-4 ID:SGTC_2511|Compound:berberine|FD-Score:2.81|P-value:9.96E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.28|P-value:1.62E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.01|P-value:4.69E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.26|P-value:2.02E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.19|P-value:2.69E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.05|P-value:4.08E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-2.94|P-value:7.19E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.03|P-value:4.35E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.39|P-value:9.95E-5 ID:SGTC_3327|Compound:9140648|FD-Score:-3.08|P-value:4.26E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-5.22|P-value:6.73E-9 ID:SGTC_79|Compound:0052-0007|FD-Score:3.05|P-value:4.03E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.78|P-value:8.12E-14 ID:SGTC_152|Compound:4469-0003|FD-Score:3.42|P-value:8.66E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.16|P-value:3.10E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.19|P-value:2.28E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:2.90|P-value:7.20E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.02|P-value:4.55E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.33|P-value:1.30E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.80|P-value:1.84E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.63|P-value:3.45E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.07|P-value:3.73E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.13|P-value:3.00E-6 ID:SGTC_1410|Compound:3909-8106|FD-Score:2.83|P-value:9.26E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.38|P-value:1.03E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.16|P-value:2.99E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.25|P-value:1.79E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-3.99|P-value:7.27E-6 ID:SGTC_2132|Compound:5317594|FD-Score:2.88|P-value:7.90E-4 ID:SGTC_2511|Compound:berberine|FD-Score:2.81|P-value:9.96E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.28|P-value:1.62E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.01|P-value:4.69E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.26|P-value:2.02E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.19|P-value:2.69E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.05|P-value:4.08E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-2.94|P-value:7.19E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.03|P-value:4.35E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.39|P-value:9.95E-5 ID:SGTC_3327|Compound:9140648|FD-Score:-3.08|P-value:4.26E-4

Top fitness defect scores for YKL024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1366 1683-0113 4.13 21.9 µM 3.00E-6 1 1.82E-5 0.33
2 SGTC_1069 diphenylcyclopropenone 3.63 8.5 µM 3.45E-5 12 1.43E-4 0.13
3 SGTC_152 4469-0003 3.42 551.2 µM 8.66E-5 21 3.10E-4 0.04
4 SGTC_3223 9129970 3.39 49.5 µM 9.95E-5 10 3.49E-4 0.05
5 SGTC_1782 st039423 3.38 80.6 µM 1.03E-4 6 3.58E-4 0.01
6 SGTC_659 k018-0002 3.33 107.0 µM 1.30E-4 13 4.38E-4 0.18
7 SGTC_2653 dihydrofissinolide 3.28 100.0 µM 1.62E-4 6 5.26E-4 0.07
8 SGTC_1975 st070967 3.25 30.8 µM 1.79E-4 20 5.71E-4 0.05
9 SGTC_440 fluspirilene 3.19 35.1 µM 2.28E-4 6 7.01E-4 0.09
10 SGTC_1235 benzylparaben 3.07 21.5 µM 3.73E-4 10 0.00106 0.03
11 SGTC_79 0052-0007 3.05 94.1 µM 4.03E-4 12 0.00114 0.03
12 SGTC_2969 9091408 3.05 28.7 µM 4.08E-4 19 0.00115 0.08
13 SGTC_3147 9097027 3.03 49.5 µM 4.35E-4 20 0.00121 0.08
14 SGTC_648 0375-0473 3.02 33.3 µM 4.55E-4 14 0.00126 0.02
15 SGTC_2762 leflunomide 3.01 42.1 µM 4.69E-4 15 0.00129 0.01
16 SGTC_455 paf C-16 2.90 10.0 µM 7.20E-4 18 0.00186 0.00
17 SGTC_2132 5317594 2.88 122.7 µM 7.90E-4 SWF1 & branched chain AA biosynthesis 16 0.00201 0.03
18 SGTC_1410 3909-8106 2.83 77.9 µM 9.26E-4 12 0.00230 0.05
19 SGTC_2511 berberine 2.81 10.5 µM 9.96E-4 60S ribosome export 22 0.00244 0.02
20 SGTC_1779 st039427 2.80 55.0 µM 0.00104 14 0.00254 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 3.47E-42 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.197 1.33E-30 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.196 1.70E-30 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.193 1.30E-29 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.160 1.20E-20 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.158 3.64E-20 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.157 7.21E-20 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.155 1.62E-19 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.147 1.24E-17 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.145 2.97E-17 YGR280C PXR1 het Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
0.144 6.04E-17 YMR301C ATM1 het Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
0.143 7.81E-17 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.142 1.13E-16 YLR249W YEF3 het Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication
0.141 2.14E-16 YJL173C RFA3 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.140 3.54E-16 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2