YKL025C / PAN3

Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL025C / PAN3

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:4.02|P-value:1.11E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.94|P-value:1.50E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:5.52|P-value:1.85E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.64|P-value:9.88E-8 ID:SGTC_229|Compound:benomyl|FD-Score:8.63|P-value:7.07E-16 ID:SGTC_348|Compound:k064-0012|FD-Score:4.02|P-value:1.12E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.28|P-value:9.72E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.62|P-value:4.51E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:4.08|P-value:9.06E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:6.80|P-value:1.74E-10 ID:SGTC_878|Compound:0828-0289|FD-Score:3.60|P-value:4.87E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.09|P-value:8.67E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.78|P-value:3.41E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:3.62|P-value:4.58E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.90|P-value:3.27E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.42|P-value:2.90E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.60|P-value:3.32E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.60|P-value:4.87E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.82|P-value:2.29E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.91|P-value:1.64E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:18.60|P-value:5.81E-67 ID:SGTC_2093|Compound:5331342|FD-Score:5.62|P-value:1.08E-7 ID:SGTC_2100|Compound:5377183|FD-Score:4.42|P-value:2.40E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.76|P-value:2.84E-4 ID:SGTC_2174|Compound:5790901|FD-Score:10.40|P-value:3.12E-22 ID:SGTC_2188|Compound:6126565|FD-Score:3.50|P-value:6.75E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.55|P-value:5.72E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.84|P-value:2.64E-6 ID:SGTC_2319|Compound:6033012|FD-Score:4.36|P-value:3.03E-5 ID:SGTC_2331|Compound:7980721|FD-Score:-3.29|P-value:9.18E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:9.08|P-value:2.22E-17 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.86|P-value:1.95E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.49|P-value:2.08E-7 ID:SGTC_2706|Compound:st078239|FD-Score:3.51|P-value:6.56E-4 ID:SGTC_2942|Compound:9052777|FD-Score:8.31|P-value:7.65E-15 ID:SGTC_2947|Compound:9072639|FD-Score:3.93|P-value:1.55E-4 ID:SGTC_2951|Compound:9072950|FD-Score:5.33|P-value:4.43E-7 ID:SGTC_2985|Compound:9022375|FD-Score:-4.07|P-value:6.22E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.33|P-value:3.43E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-3.70|P-value:2.35E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.68|P-value:3.65E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.60|P-value:4.88E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.41|P-value:6.40E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:4.02|P-value:1.11E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.94|P-value:1.50E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:5.52|P-value:1.85E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.64|P-value:9.88E-8 ID:SGTC_229|Compound:benomyl|FD-Score:8.63|P-value:7.07E-16 ID:SGTC_348|Compound:k064-0012|FD-Score:4.02|P-value:1.12E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.28|P-value:9.72E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.62|P-value:4.51E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:4.08|P-value:9.06E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:6.80|P-value:1.74E-10 ID:SGTC_878|Compound:0828-0289|FD-Score:3.60|P-value:4.87E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.09|P-value:8.67E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.78|P-value:3.41E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:3.62|P-value:4.58E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.90|P-value:3.27E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.42|P-value:2.90E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.60|P-value:3.32E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.60|P-value:4.87E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.82|P-value:2.29E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.91|P-value:1.64E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:18.60|P-value:5.81E-67 ID:SGTC_2093|Compound:5331342|FD-Score:5.62|P-value:1.08E-7 ID:SGTC_2100|Compound:5377183|FD-Score:4.42|P-value:2.40E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.76|P-value:2.84E-4 ID:SGTC_2174|Compound:5790901|FD-Score:10.40|P-value:3.12E-22 ID:SGTC_2188|Compound:6126565|FD-Score:3.50|P-value:6.75E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.55|P-value:5.72E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.84|P-value:2.64E-6 ID:SGTC_2319|Compound:6033012|FD-Score:4.36|P-value:3.03E-5 ID:SGTC_2331|Compound:7980721|FD-Score:-3.29|P-value:9.18E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:9.08|P-value:2.22E-17 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.86|P-value:1.95E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.49|P-value:2.08E-7 ID:SGTC_2706|Compound:st078239|FD-Score:3.51|P-value:6.56E-4 ID:SGTC_2942|Compound:9052777|FD-Score:8.31|P-value:7.65E-15 ID:SGTC_2947|Compound:9072639|FD-Score:3.93|P-value:1.55E-4 ID:SGTC_2951|Compound:9072950|FD-Score:5.33|P-value:4.43E-7 ID:SGTC_2985|Compound:9022375|FD-Score:-4.07|P-value:6.22E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.33|P-value:3.43E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-3.70|P-value:2.35E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.68|P-value:3.65E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.60|P-value:4.88E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.41|P-value:6.40E-4

Top fitness defect scores for YKL025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1875 nocodazole 18.60 6.0 µM 5.81E-67 tubulin folding & SWR complex 5 2.18E-77
2 SGTC_2174 5790901 10.40 200.0 µM 3.12E-22 tubulin folding & SWR complex 9 1.31E-25
3 SGTC_2407 paclitaxel 9.08 400.0 µM 2.22E-17 4 5.48E-20
4 SGTC_229 benomyl 8.63 22.9 µM 7.07E-16 tubulin folding & SWR complex 12 3.03E-18
5 SGTC_2942 9052777 8.31 62.2 µM 7.65E-15 2 4.79E-17
6 SGTC_843 0310-0051 6.80 143.0 µM 1.74E-10 3 5.37E-12
7 SGTC_221 trifluoperazine 5.64 10.3 µM 9.88E-8 NEO1-PIK1 136 8.42E-9
8 SGTC_2093 5331342 5.62 194.4 µM 1.08E-7 16 9.38E-9
9 SGTC_210 3551-0445 5.52 56.8 µM 1.85E-7 30 1.74E-8
10 SGTC_2651 1327-0036 5.49 5.0 µM 2.08E-7 88 1.99E-8
11 SGTC_1374 2889-5571 5.42 141.0 µM 2.90E-7 RSC complex & mRNA processing 14 2.94E-8
12 SGTC_2951 9072950 5.33 58.1 µM 4.43E-7 ERG2 10 4.79E-8
13 SGTC_1326 1431-2094 4.90 10.8 µM 3.27E-6 tubulin folding & SWR complex 18 4.88E-7
14 SGTC_2100 5377183 4.42 190.0 µM 2.40E-5 60S ribosome export 7 4.91E-6
15 SGTC_2319 6033012 4.36 152.6 µM 3.03E-5 tubulin folding & SWR complex 25 6.44E-6
16 SGTC_3037 9091026 4.33 49.5 µM 3.43E-5 NEO1-PIK1 103 7.44E-6
17 SGTC_940 3232-1287 4.09 54.8 µM 8.67E-5 NEO1 31 2.18E-5
18 SGTC_833 3852-0053 4.08 558.0 µM 9.06E-5 13 2.29E-5
19 SGTC_47 0149-0135 4.02 24.2 µM 1.11E-4 TSC3-RPN4 18 2.91E-5
20 SGTC_348 k064-0012 4.02 10.7 µM 1.12E-4 60S ribosome export 13 2.93E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.488 5.70E-200 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.329 1.19E-85 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.318 6.03E-80 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.303 4.80E-72 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.293 1.17E-67 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.270 4.02E-57 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.253 3.27E-50 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.252 7.33E-50 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.247 9.54E-48 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.241 1.30E-45 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.238 1.23E-44 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.233 1.73E-42 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.225 9.89E-40 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.207 9.73E-34 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.199 2.50E-31 YMR138W CIN4 hom GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog