YKL026C / GPX1

Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL026C / GPX1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:6.01|P-value:1.43E-9 ID:SGTC_55|Compound:0767-0285|FD-Score:3.45|P-value:3.31E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.20|P-value:1.63E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.81|P-value:7.68E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.24|P-value:6.35E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.27|P-value:6.15E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.12|P-value:9.55E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.49|P-value:4.64E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.57|P-value:2.07E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:-4.64|P-value:2.04E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:4.19|P-value:1.71E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.11|P-value:2.40E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.91|P-value:5.22E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.43|P-value:3.55E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.14|P-value:9.80E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.23|P-value:7.11E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.25|P-value:6.62E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.73|P-value:7.19E-9 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.82|P-value:8.11E-5 ID:SGTC_1802|Compound:st050112|FD-Score:3.77|P-value:9.86E-5 ID:SGTC_1840|Compound:st055363|FD-Score:-3.96|P-value:4.16E-5 ID:SGTC_1860|Compound:st056228|FD-Score:4.28|P-value:1.15E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.38|P-value:4.15E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.48|P-value:2.94E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.60|P-value:1.92E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.87|P-value:6.52E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.08|P-value:2.61E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.16|P-value:1.73E-7 ID:SGTC_2601|Compound:securinine|FD-Score:3.94|P-value:5.02E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.24|P-value:6.82E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-5.65|P-value:1.06E-8 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-4.68|P-value:1.66E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.40|P-value:6.78E-6 ID:SGTC_2786|Compound:7743617|FD-Score:-3.85|P-value:6.59E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.54|P-value:2.18E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.97|P-value:4.40E-5 ID:SGTC_2877|Compound:9040724|FD-Score:-3.20|P-value:7.40E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.21|P-value:7.63E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.46|P-value:3.14E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.51|P-value:2.68E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.62|P-value:1.72E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.87|P-value:6.61E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:6.01|P-value:1.43E-9 ID:SGTC_55|Compound:0767-0285|FD-Score:3.45|P-value:3.31E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.20|P-value:1.63E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.81|P-value:7.68E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.24|P-value:6.35E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.27|P-value:6.15E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.12|P-value:9.55E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.49|P-value:4.64E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.57|P-value:2.07E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:-4.64|P-value:2.04E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:4.19|P-value:1.71E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.11|P-value:2.40E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.91|P-value:5.22E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.43|P-value:3.55E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.14|P-value:9.80E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.23|P-value:7.11E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.25|P-value:6.62E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.73|P-value:7.19E-9 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.82|P-value:8.11E-5 ID:SGTC_1802|Compound:st050112|FD-Score:3.77|P-value:9.86E-5 ID:SGTC_1840|Compound:st055363|FD-Score:-3.96|P-value:4.16E-5 ID:SGTC_1860|Compound:st056228|FD-Score:4.28|P-value:1.15E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.38|P-value:4.15E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.48|P-value:2.94E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.60|P-value:1.92E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.87|P-value:6.52E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.08|P-value:2.61E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.16|P-value:1.73E-7 ID:SGTC_2601|Compound:securinine|FD-Score:3.94|P-value:5.02E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.24|P-value:6.82E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-5.65|P-value:1.06E-8 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-4.68|P-value:1.66E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.40|P-value:6.78E-6 ID:SGTC_2786|Compound:7743617|FD-Score:-3.85|P-value:6.59E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.54|P-value:2.18E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.97|P-value:4.40E-5 ID:SGTC_2877|Compound:9040724|FD-Score:-3.20|P-value:7.40E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.21|P-value:7.63E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.46|P-value:3.14E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.51|P-value:2.68E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.62|P-value:1.72E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.87|P-value:6.61E-5

Top fitness defect scores for YKL026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_49 0717-0965 6.01 32.1 µM 1.43E-9 60S ribosome export 2 9.47E-10
2 SGTC_1511 0906-3109 5.73 28.5 µM 7.19E-9 excess fatty acid 16 4.93E-9
3 SGTC_2600 tangeritin 5.16 88.0 µM 1.73E-7 12 1.27E-7
4 SGTC_773 4358-1457 4.49 44.6 µM 4.64E-6 30 3.63E-6
5 SGTC_2776 terbinafine 4.40 19.9 µM 6.78E-6 cell wall signaling 45 5.35E-6
6 SGTC_1860 st056228 4.28 74.6 µM 1.15E-5 11 9.21E-6
7 SGTC_60 0986-0278 4.20 202.0 µM 1.63E-5 10 1.31E-5
8 SGTC_805 3852-0218 4.19 479.0 µM 1.71E-5 ERAD & cell cycle 62 1.37E-5
9 SGTC_807 1315-0151 4.11 48.0 µM 2.40E-5 22 1.95E-5
10 SGTC_2821 7996764 3.97 71.4 µM 4.40E-5 39 3.61E-5
11 SGTC_2601 securinine 3.94 100.0 µM 5.02E-5 30 4.13E-5
12 SGTC_2593 nobiletin 3.87 86.2 µM 6.52E-5 30 5.39E-5
13 SGTC_3281 9140613 3.87 49.5 µM 6.61E-5 RPP1 & pyrimidine depletion 22 5.46E-5
14 SGTC_1681 tripelennamine 3.82 100.0 µM 8.11E-5 25 6.73E-5
15 SGTC_1802 st050112 3.77 57.9 µM 9.86E-5 14 8.22E-5
16 SGTC_3219 9131112 3.62 49.5 µM 1.72E-4 Golgi 44 1.45E-4
17 SGTC_2588 indole-3-carbinol 3.60 100.0 µM 1.92E-4 62 1.62E-4
18 SGTC_801 0866-0028 3.57 10.1 µM 2.07E-4 43 1.75E-4
19 SGTC_3216 9129716 3.51 49.5 µM 2.68E-4 RPP1 & pyrimidine depletion 39 2.28E-4
20 SGTC_2315 7733312 3.48 200.0 µM 2.94E-4 38 2.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.34E-12 YGR175C ERG1 het Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
0.107 4.88E-10 YGR176W_d YGR176W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.106 7.95E-10 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.098 1.17E-8 YDR536W STL1 hom Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
0.096 2.47E-8 YLR103C CDC45 het DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
0.093 6.01E-8 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.093 6.47E-8 YER119C AVT6 hom Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication
0.092 9.48E-8 YCR020C-A MAK31 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family
0.088 3.69E-7 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.081 2.29E-6 YIL138C TPM2 hom Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication
0.077 7.17E-6 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.077 8.16E-6 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.076 9.78E-6 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.076 1.14E-5 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.075 1.35E-5 YNL072W RNH201 hom Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome