YKL027W

Protein of unknown function, localized to the mitochondrial outer membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL027W / YKL027W

Click on Significant Values for Screen Details ID:SGTC_90|Compound:0870-0863|FD-Score:3.52|P-value:2.48E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.79|P-value:9.07E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:4.69|P-value:1.77E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:3.42|P-value:3.62E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.50|P-value:2.64E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:4.53|P-value:3.69E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.21|P-value:7.48E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.15|P-value:8.98E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.16|P-value:8.89E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.23|P-value:1.46E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:5.70|P-value:8.68E-9 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.16|P-value:9.07E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.31|P-value:5.42E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.18|P-value:8.42E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.33|P-value:4.97E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.02|P-value:3.51E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.36|P-value:8.12E-6 ID:SGTC_1547|Compound:harmine|FD-Score:4.55|P-value:3.38E-6 ID:SGTC_1808|Compound:st050063|FD-Score:-3.38|P-value:3.99E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.72|P-value:1.56E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.28|P-value:5.70E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.86|P-value:6.50E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.65|P-value:2.19E-6 ID:SGTC_1934|Compound:st074720|FD-Score:3.62|P-value:1.73E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.65|P-value:1.53E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.38|P-value:4.10E-4 ID:SGTC_2155|Compound:5570423|FD-Score:-3.56|P-value:2.09E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.16|P-value:8.83E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-3.22|P-value:7.04E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.95|P-value:4.70E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-4.37|P-value:7.62E-6 ID:SGTC_2310|Compound:7668677|FD-Score:4.18|P-value:1.82E-5 ID:SGTC_2315|Compound:7733312|FD-Score:7.74|P-value:9.49E-15 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.62|P-value:2.31E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.87|P-value:6.32E-5 ID:SGTC_2438|Compound:5259590|FD-Score:-3.20|P-value:7.66E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.50|P-value:2.73E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-4.00|P-value:3.66E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.58|P-value:2.03E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.41|P-value:3.80E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.51|P-value:4.16E-6 ID:SGTC_3189|Compound:9110682|FD-Score:3.58|P-value:2.04E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.52|P-value:2.48E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.79|P-value:9.07E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:4.69|P-value:1.77E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:3.42|P-value:3.62E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.50|P-value:2.64E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:4.53|P-value:3.69E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.21|P-value:7.48E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.15|P-value:8.98E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.16|P-value:8.89E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.23|P-value:1.46E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:5.70|P-value:8.68E-9 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.16|P-value:9.07E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.31|P-value:5.42E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.18|P-value:8.42E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.33|P-value:4.97E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.02|P-value:3.51E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.36|P-value:8.12E-6 ID:SGTC_1547|Compound:harmine|FD-Score:4.55|P-value:3.38E-6 ID:SGTC_1808|Compound:st050063|FD-Score:-3.38|P-value:3.99E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.72|P-value:1.56E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.28|P-value:5.70E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.86|P-value:6.50E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.65|P-value:2.19E-6 ID:SGTC_1934|Compound:st074720|FD-Score:3.62|P-value:1.73E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.65|P-value:1.53E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.38|P-value:4.10E-4 ID:SGTC_2155|Compound:5570423|FD-Score:-3.56|P-value:2.09E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.16|P-value:8.83E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-3.22|P-value:7.04E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.95|P-value:4.70E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-4.37|P-value:7.62E-6 ID:SGTC_2310|Compound:7668677|FD-Score:4.18|P-value:1.82E-5 ID:SGTC_2315|Compound:7733312|FD-Score:7.74|P-value:9.49E-15 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.62|P-value:2.31E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.87|P-value:6.32E-5 ID:SGTC_2438|Compound:5259590|FD-Score:-3.20|P-value:7.66E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.50|P-value:2.73E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-4.00|P-value:3.66E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.58|P-value:2.03E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.41|P-value:3.80E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.51|P-value:4.16E-6 ID:SGTC_3189|Compound:9110682|FD-Score:3.58|P-value:2.04E-4

Top fitness defect scores for YKL027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2315 7733312 7.74 200.0 µM 9.49E-15 2 4.86E-15
2 SGTC_1237 0330-0133 5.70 46.1 µM 8.68E-9 ergosterol biosynthesis 5 5.97E-9
3 SGTC_1844 rapamycin 4.72 4.0 nM 1.56E-6 121 1.20E-6
4 SGTC_780 0109-0199 4.69 192.0 µM 1.77E-6 4 1.37E-6
5 SGTC_1910 st062352 4.65 60.4 µM 2.19E-6 17 1.70E-6
6 SGTC_1547 harmine 4.55 94.2 µM 3.38E-6 ergosterol biosynthesis 29 2.64E-6
7 SGTC_880 0833-0487 4.53 87.2 µM 3.69E-6 mitochondrial processes 13 2.89E-6
8 SGTC_2991 9074669 4.51 71.4 µM 4.16E-6 azole & statin 43 3.26E-6
9 SGTC_1534 6-azauridine 4.36 81.6 µM 8.12E-6 RNA pol III & RNase P/MRP 14 6.46E-6
10 SGTC_1230 0170-0365 4.23 3.8 µM 1.46E-5 endomembrane recycling 55 1.17E-5
11 SGTC_2310 7668677 4.18 200.0 µM 1.82E-5 22 1.47E-5
12 SGTC_1526 st051518 4.02 75.0 µM 3.51E-5 18 2.88E-5
13 SGTC_2283 7944793 3.95 200.0 µM 4.70E-5 41 3.88E-5
14 SGTC_120 rhodamine 6G 3.79 52.3 µM 9.07E-5 mitochondrial processes 38 7.59E-5
15 SGTC_1945 st075991 3.65 56.6 µM 1.53E-4 60S ribosome export 29 1.29E-4
16 SGTC_1934 st074720 3.62 32.6 µM 1.73E-4 70 1.47E-4
17 SGTC_2594 a-mangostin 3.58 100.0 µM 2.03E-4 42 1.73E-4
18 SGTC_3189 9110682 3.58 49.5 µM 2.04E-4 50 1.73E-4
19 SGTC_90 0870-0863 3.52 4.6 µM 2.48E-4 63 2.12E-4
20 SGTC_2476 5806916 3.50 10.5 µM 2.73E-4 25 2.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.77E-17 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.126 2.18E-13 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.114 3.88E-11 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.105 1.15E-9 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.104 1.56E-9 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.100 6.06E-9 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.099 7.82E-9 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.099 9.67E-9 YDL064W UBC9 het SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
0.098 1.11E-8 YER112W LSM4 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
0.097 1.85E-8 YJL093C TOK1 hom Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
0.093 6.58E-8 YLR376C PSY3 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
0.092 8.61E-8 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.092 9.66E-8 YLR232W_d YLR232W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5
0.091 1.49E-7 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.089 2.10E-7 YDL241W_p YDL241W_p hom Putative protein of unknown function; YDL241W is not an essential gene