YKL029C / MAE1

Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL029C / MAE1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.03|P-value:1.84E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.45|P-value:2.06E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.14|P-value:6.40E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.23|P-value:6.17E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.95|P-value:2.64E-5 ID:SGTC_401|Compound:neomycin|FD-Score:-3.12|P-value:9.11E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.34|P-value:4.08E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.34|P-value:3.07E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.47|P-value:2.37E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:4.61|P-value:1.20E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.42|P-value:3.11E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:4.44|P-value:2.81E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:3.17|P-value:5.77E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:4.06|P-value:1.61E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:4.40|P-value:3.37E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.26|P-value:5.50E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.41|P-value:4.80E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:3.80|P-value:5.01E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.20|P-value:6.95E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.56|P-value:1.83E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.01|P-value:9.81E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.71|P-value:7.32E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.03|P-value:9.17E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:5.08|P-value:1.06E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.07|P-value:1.54E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.43|P-value:3.01E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:-3.11|P-value:9.27E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.53|P-value:2.01E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.26|P-value:4.17E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.48|P-value:2.47E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.34|P-value:4.23E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.33|P-value:3.22E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.21|P-value:4.86E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.79|P-value:5.19E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.81|P-value:6.71E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:4.61|P-value:1.20E-6 ID:SGTC_1723|Compound:st034307|FD-Score:3.05|P-value:8.62E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.96|P-value:2.53E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.29|P-value:3.75E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.11|P-value:7.06E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.95|P-value:2.63E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.47|P-value:1.90E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.03|P-value:9.30E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.10|P-value:7.41E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.25|P-value:4.22E-4 ID:SGTC_2259|Compound:7964009|FD-Score:6.74|P-value:3.13E-12 ID:SGTC_2290|Compound:7904846|FD-Score:3.28|P-value:3.89E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.38|P-value:3.56E-4 ID:SGTC_2326|Compound:6164455|FD-Score:4.51|P-value:1.97E-6 ID:SGTC_2364|Compound:9055074|FD-Score:7.15|P-value:1.64E-13 ID:SGTC_2412|Compound:st077135|FD-Score:-3.47|P-value:2.56E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.17|P-value:5.74E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.27|P-value:4.00E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.05|P-value:8.74E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.42|P-value:2.28E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.03|P-value:9.39E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.27|P-value:3.94E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.05|P-value:8.72E-4 ID:SGTC_3099|Compound:9120367|FD-Score:3.13|P-value:6.58E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.38|P-value:3.65E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-7.48|P-value:2.42E-14 ID:SGTC_3147|Compound:9097027|FD-Score:4.20|P-value:8.61E-6 ID:SGTC_3158|Compound:9100007|FD-Score:6.06|P-value:3.21E-10 ID:SGTC_3159|Compound:9100096|FD-Score:4.48|P-value:2.27E-6 ID:SGTC_3179|Compound:9107801|FD-Score:4.01|P-value:2.02E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.10|P-value:7.32E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.82|P-value:4.23E-7 ID:SGTC_3207|Compound:9114163|FD-Score:3.33|P-value:3.15E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.03|P-value:1.84E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.45|P-value:2.06E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.14|P-value:6.40E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.23|P-value:6.17E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.95|P-value:2.64E-5 ID:SGTC_401|Compound:neomycin|FD-Score:-3.12|P-value:9.11E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.34|P-value:4.08E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.34|P-value:3.07E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.47|P-value:2.37E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:4.61|P-value:1.20E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.42|P-value:3.11E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:4.44|P-value:2.81E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:3.17|P-value:5.77E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:4.06|P-value:1.61E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:4.40|P-value:3.37E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.26|P-value:5.50E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.41|P-value:4.80E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:3.80|P-value:5.01E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.20|P-value:6.95E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-3.56|P-value:1.83E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.01|P-value:9.81E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.71|P-value:7.32E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.03|P-value:9.17E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:5.08|P-value:1.06E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.07|P-value:1.54E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.43|P-value:3.01E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:-3.11|P-value:9.27E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.53|P-value:2.01E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.26|P-value:4.17E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.48|P-value:2.47E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.34|P-value:4.23E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.33|P-value:3.22E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.21|P-value:4.86E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.79|P-value:5.19E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.81|P-value:6.71E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:4.61|P-value:1.20E-6 ID:SGTC_1723|Compound:st034307|FD-Score:3.05|P-value:8.62E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.96|P-value:2.53E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.29|P-value:3.75E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.11|P-value:7.06E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.95|P-value:2.63E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.47|P-value:1.90E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.03|P-value:9.30E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.10|P-value:7.41E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.25|P-value:4.22E-4 ID:SGTC_2259|Compound:7964009|FD-Score:6.74|P-value:3.13E-12 ID:SGTC_2290|Compound:7904846|FD-Score:3.28|P-value:3.89E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.38|P-value:3.56E-4 ID:SGTC_2326|Compound:6164455|FD-Score:4.51|P-value:1.97E-6 ID:SGTC_2364|Compound:9055074|FD-Score:7.15|P-value:1.64E-13 ID:SGTC_2412|Compound:st077135|FD-Score:-3.47|P-value:2.56E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.17|P-value:5.74E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.27|P-value:4.00E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.05|P-value:8.74E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.42|P-value:2.28E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.03|P-value:9.39E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.27|P-value:3.94E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.05|P-value:8.72E-4 ID:SGTC_3099|Compound:9120367|FD-Score:3.13|P-value:6.58E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.38|P-value:3.65E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-7.48|P-value:2.42E-14 ID:SGTC_3147|Compound:9097027|FD-Score:4.20|P-value:8.61E-6 ID:SGTC_3158|Compound:9100007|FD-Score:6.06|P-value:3.21E-10 ID:SGTC_3159|Compound:9100096|FD-Score:4.48|P-value:2.27E-6 ID:SGTC_3179|Compound:9107801|FD-Score:4.01|P-value:2.02E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.10|P-value:7.32E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.82|P-value:4.23E-7 ID:SGTC_3207|Compound:9114163|FD-Score:3.33|P-value:3.15E-4

Top fitness defect scores for YKL029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2364 9055074 7.15 200.0 µM 1.64E-13 3 4.45E-13
2 SGTC_2259 7964009 6.74 200.0 µM 3.13E-12 superoxide 10 7.76E-12
3 SGTC_3158 9100007 6.06 49.5 µM 3.21E-10 3 6.88E-10
4 SGTC_976 1348-1067 5.08 47.6 µM 1.06E-7 60S ribosome export 9 1.89E-7
5 SGTC_3197 9113331 4.82 49.5 µM 4.23E-7 20 7.21E-7
6 SGTC_1718 roemerine 4.61 11.9 µM 1.20E-6 redox potentiating 27 1.97E-6
7 SGTC_542 3381-0244 4.61 89.3 µM 1.20E-6 24 1.98E-6
8 SGTC_2326 6164455 4.51 177.6 µM 1.97E-6 mitochondrial processes 14 3.19E-6
9 SGTC_3159 9100096 4.48 49.5 µM 2.27E-6 11 3.66E-6
10 SGTC_539 4859-0462 4.47 2.5 µM 2.37E-6 RNA pol III & RNase P/MRP 11 3.82E-6
11 SGTC_590 k048-0076 4.44 22.4 µM 2.81E-6 RSC & ERG11 6 4.50E-6
12 SGTC_1091 telmisartan 4.43 47.6 µM 3.01E-6 6 4.81E-6
13 SGTC_789 1309-1135 4.40 70.6 µM 3.37E-6 ERG2 18 5.37E-6
14 SGTC_3147 9097027 4.20 49.5 µM 8.61E-6 14 1.33E-5
15 SGTC_1028 k015-0029 4.07 4.8 µM 1.54E-5 23 2.33E-5
16 SGTC_753 1322-0200 4.06 289.0 µM 1.61E-5 14 2.43E-5
17 SGTC_113 0099-0221 4.03 2.5 µM 1.84E-5 23 2.76E-5
18 SGTC_3179 9107801 4.01 49.5 µM 2.02E-5 9 3.02E-5
19 SGTC_1738 st035555 3.96 74.0 µM 2.53E-5 TSC3-RPN4 31 3.77E-5
20 SGTC_1926 methyl fluorone black 3.95 53.6 µM 2.63E-5 DNA intercalators 62 3.91E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.05E-9 YMR153W NUP53 hom FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication
0.092 9.41E-8 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.091 1.52E-7 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.090 1.90E-7 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.090 2.10E-7 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.088 3.75E-7 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.082 1.92E-6 YAL033W POP5 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.080 3.58E-6 YAL049C AIM2 hom Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor
0.075 1.23E-5 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.073 2.31E-5 YOR148C SPP2 het Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
0.072 3.27E-5 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.071 3.71E-5 YER032W FIR1 hom Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
0.069 6.40E-5 YER034W YER034W hom Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
0.069 6.96E-5 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.068 8.40E-5 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP