YKL031W_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL031W / YKL031W

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:3.87|P-value:7.74E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:3.46|P-value:3.56E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.40|P-value:4.41E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:6.60|P-value:5.29E-11 ID:SGTC_701|Compound:4424-0219|FD-Score:4.90|P-value:8.21E-7 ID:SGTC_713|Compound:1488-1073|FD-Score:3.41|P-value:4.25E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.84|P-value:8.81E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.58|P-value:2.33E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.17|P-value:9.85E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.43|P-value:3.93E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:4.42|P-value:7.60E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.26|P-value:1.53E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.34|P-value:5.45E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.52|P-value:2.86E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.46|P-value:3.58E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:5.15|P-value:2.37E-7 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.65|P-value:1.76E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-4.80|P-value:1.31E-6 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.06|P-value:3.68E-7 ID:SGTC_1833|Compound:st055984|FD-Score:3.20|P-value:8.67E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-3.53|P-value:2.76E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.22|P-value:8.35E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.37|P-value:4.87E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.21|P-value:8.61E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.57|P-value:2.37E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.60|P-value:3.42E-6 ID:SGTC_2788|Compound:5282734|FD-Score:4.17|P-value:2.28E-5 ID:SGTC_2806|Compound:7952793|FD-Score:4.38|P-value:9.04E-6 ID:SGTC_3050|Compound:9093513|FD-Score:3.86|P-value:7.91E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.67|P-value:1.68E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.22|P-value:8.31E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.87|P-value:7.74E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:3.46|P-value:3.56E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.40|P-value:4.41E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:6.60|P-value:5.29E-11 ID:SGTC_701|Compound:4424-0219|FD-Score:4.90|P-value:8.21E-7 ID:SGTC_713|Compound:1488-1073|FD-Score:3.41|P-value:4.25E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.84|P-value:8.81E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.58|P-value:2.33E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.17|P-value:9.85E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.43|P-value:3.93E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:4.42|P-value:7.60E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.26|P-value:1.53E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.34|P-value:5.45E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.52|P-value:2.86E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.46|P-value:3.58E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:5.15|P-value:2.37E-7 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.65|P-value:1.76E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-4.80|P-value:1.31E-6 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.06|P-value:3.68E-7 ID:SGTC_1833|Compound:st055984|FD-Score:3.20|P-value:8.67E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-3.53|P-value:2.76E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.22|P-value:8.35E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.37|P-value:4.87E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.21|P-value:8.61E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.57|P-value:2.37E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.60|P-value:3.42E-6 ID:SGTC_2788|Compound:5282734|FD-Score:4.17|P-value:2.28E-5 ID:SGTC_2806|Compound:7952793|FD-Score:4.38|P-value:9.04E-6 ID:SGTC_3050|Compound:9093513|FD-Score:3.86|P-value:7.91E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.67|P-value:1.68E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.22|P-value:8.31E-4

Top fitness defect scores for YKL031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_556 4058-0063 6.60 51.5 µM 5.29E-11 5 2.02E-11
2 SGTC_1367 1812-0510 5.15 76.9 µM 2.37E-7 4 1.31E-7
3 SGTC_1528 arabinosylhypoxanthine 5.06 74.6 µM 3.68E-7 11 2.06E-7
4 SGTC_701 4424-0219 4.90 185.0 µM 8.21E-7 calcium & mitochondrial duress 8 4.77E-7
5 SGTC_2781 5567276 4.60 71.4 µM 3.42E-6 29 2.11E-6
6 SGTC_990 3985-0011 4.42 41.3 µM 7.60E-6 amide catabolism 11 4.86E-6
7 SGTC_2806 7952793 4.38 58.4 µM 9.04E-6 13 5.83E-6
8 SGTC_1085 doxorubicin 4.26 7.7 µM 1.53E-5 anthracycline transcription coupled DNA repair 13 1.01E-5
9 SGTC_2788 5282734 4.17 71.4 µM 2.28E-5 37 1.53E-5
10 SGTC_103 0844-0104 3.87 51.8 µM 7.74E-5 ERAD & cell cycle 151 5.47E-5
11 SGTC_3050 9093513 3.86 49.5 µM 7.91E-5 19 5.60E-5
12 SGTC_716 1683-5115 3.84 658.0 µM 8.81E-5 22 6.26E-5
13 SGTC_3067 9117431 3.67 49.5 µM 1.68E-4 19 1.23E-4
14 SGTC_746 1095-0025 3.58 46.6 µM 2.33E-4 RSC & ERG11 21 1.73E-4
15 SGTC_2656 pseudo-anisatin 3.57 100.0 µM 2.37E-4 2 1.76E-4
16 SGTC_1349 flufenamic acid 3.52 69.0 µM 2.86E-4 26 2.14E-4
17 SGTC_502 l-744,832 3.46 89.3 µM 3.56E-4 calcium & mitochondrial duress 47 2.68E-4
18 SGTC_713 1488-1073 3.41 324.0 µM 4.25E-4 ERG2 23 3.23E-4
19 SGTC_3072 9116419 3.22 49.5 µM 8.31E-4 ERG2 48 6.50E-4
20 SGTC_2051 5263410 3.22 176.0 µM 8.35E-4 38 6.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.70E-12 YNR021W_p YNR021W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene
0.103 2.36E-9 YDR134C YDR134C hom Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication
0.097 1.86E-8 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.095 4.02E-8 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.094 5.83E-8 YNL145W MFA2 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
0.091 1.23E-7 YJL078C PRY3 hom Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
0.082 2.00E-6 YKL088W CAB3 het Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC
0.079 4.28E-6 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.078 5.52E-6 YJR079W_p YJR079W_p hom Putative protein of unknown function; mutation results in impaired mitochondrial respiration
0.078 5.84E-6 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.077 9.06E-6 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.076 9.90E-6 YNL009W IDP3 hom Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication
0.076 1.15E-5 YIR044C YIR044C hom Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.076 1.20E-5 YDR273W DON1 hom Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
0.075 1.56E-5 YCL049C_p YCL049C_p hom Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene