YKL033W-A_p

Putative protein of unknown function; similar to uncharacterized proteins from other fungi

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL033W-A / YKL033W-A

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:5.18|P-value:9.83E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:20.00|P-value:3.61E-78 ID:SGTC_75|Compound:0159-0059|FD-Score:5.25|P-value:7.26E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.36|P-value:5.92E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.62|P-value:1.17E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:7.89|P-value:1.48E-13 ID:SGTC_304|Compound:1310-0298|FD-Score:5.54|P-value:1.80E-7 ID:SGTC_369|Compound:0957-0393|FD-Score:5.25|P-value:7.13E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:3.74|P-value:3.34E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.53|P-value:1.84E-7 ID:SGTC_531|Compound:3788-1495|FD-Score:3.70|P-value:3.81E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.68|P-value:4.05E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.37|P-value:4.00E-7 ID:SGTC_755|Compound:1995-0008|FD-Score:3.83|P-value:2.39E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.84|P-value:2.35E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.08|P-value:1.55E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:8.74|P-value:2.99E-16 ID:SGTC_970|Compound:1315-0089|FD-Score:3.64|P-value:4.60E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:5.49|P-value:2.29E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:4.61|P-value:1.19E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.28|P-value:4.64E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.43|P-value:9.21E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.82|P-value:4.88E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.65|P-value:1.05E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.70|P-value:8.20E-6 ID:SGTC_1660|Compound:st012960|FD-Score:4.36|P-value:3.36E-5 ID:SGTC_1664|Compound:st014217|FD-Score:4.35|P-value:3.41E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.49|P-value:7.62E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.42|P-value:2.67E-5 ID:SGTC_2071|Compound:5230951|FD-Score:3.42|P-value:9.58E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.59|P-value:1.34E-5 ID:SGTC_2152|Compound:5568786|FD-Score:3.68|P-value:3.99E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-3.75|P-value:1.52E-4 ID:SGTC_2314|Compound:7727897|FD-Score:4.19|P-value:6.33E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.44|P-value:8.95E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.47|P-value:8.14E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.58|P-value:5.70E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-4.38|P-value:1.34E-5 ID:SGTC_2488|Compound:5268135|FD-Score:-3.64|P-value:2.31E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:7.33|P-value:6.40E-12 ID:SGTC_2584|Compound:androsterone|FD-Score:3.62|P-value:4.85E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:5.05|P-value:1.76E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-5.03|P-value:7.57E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:5.25|P-value:7.09E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.11|P-value:8.57E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.80|P-value:2.64E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.24|P-value:5.32E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.60|P-value:5.23E-4 ID:SGTC_3123|Compound:9126162|FD-Score:5.59|P-value:1.39E-7 ID:SGTC_3128|Compound:9127691|FD-Score:4.79|P-value:5.57E-6 ID:SGTC_3132|Compound:9126706|FD-Score:5.28|P-value:6.27E-7 ID:SGTC_3143|Compound:9086658|FD-Score:3.90|P-value:1.85E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.16|P-value:7.08E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:5.18|P-value:9.83E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:20.00|P-value:3.61E-78 ID:SGTC_75|Compound:0159-0059|FD-Score:5.25|P-value:7.26E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.36|P-value:5.92E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.62|P-value:1.17E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:7.89|P-value:1.48E-13 ID:SGTC_304|Compound:1310-0298|FD-Score:5.54|P-value:1.80E-7 ID:SGTC_369|Compound:0957-0393|FD-Score:5.25|P-value:7.13E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:3.74|P-value:3.34E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.53|P-value:1.84E-7 ID:SGTC_531|Compound:3788-1495|FD-Score:3.70|P-value:3.81E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.68|P-value:4.05E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.37|P-value:4.00E-7 ID:SGTC_755|Compound:1995-0008|FD-Score:3.83|P-value:2.39E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.84|P-value:2.35E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.08|P-value:1.55E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:8.74|P-value:2.99E-16 ID:SGTC_970|Compound:1315-0089|FD-Score:3.64|P-value:4.60E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:5.49|P-value:2.29E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:4.61|P-value:1.19E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.28|P-value:4.64E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.43|P-value:9.21E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.82|P-value:4.88E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.65|P-value:1.05E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.70|P-value:8.20E-6 ID:SGTC_1660|Compound:st012960|FD-Score:4.36|P-value:3.36E-5 ID:SGTC_1664|Compound:st014217|FD-Score:4.35|P-value:3.41E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.49|P-value:7.62E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.42|P-value:2.67E-5 ID:SGTC_2071|Compound:5230951|FD-Score:3.42|P-value:9.58E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.59|P-value:1.34E-5 ID:SGTC_2152|Compound:5568786|FD-Score:3.68|P-value:3.99E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-3.75|P-value:1.52E-4 ID:SGTC_2314|Compound:7727897|FD-Score:4.19|P-value:6.33E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.44|P-value:8.95E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.47|P-value:8.14E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.58|P-value:5.70E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-4.38|P-value:1.34E-5 ID:SGTC_2488|Compound:5268135|FD-Score:-3.64|P-value:2.31E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:7.33|P-value:6.40E-12 ID:SGTC_2584|Compound:androsterone|FD-Score:3.62|P-value:4.85E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:5.05|P-value:1.76E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-5.03|P-value:7.57E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:5.25|P-value:7.09E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.11|P-value:8.57E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.80|P-value:2.64E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.24|P-value:5.32E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.60|P-value:5.23E-4 ID:SGTC_3123|Compound:9126162|FD-Score:5.59|P-value:1.39E-7 ID:SGTC_3128|Compound:9127691|FD-Score:4.79|P-value:5.57E-6 ID:SGTC_3132|Compound:9126706|FD-Score:5.28|P-value:6.27E-7 ID:SGTC_3143|Compound:9086658|FD-Score:3.90|P-value:1.85E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.16|P-value:7.08E-5

Top fitness defect scores for YKL033W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 20.00 9.0 µM 3.61E-78 cell wall 10 1.11E-89
2 SGTC_951 1171-0579 8.74 82.7 µM 2.99E-16 cell wall 12 1.18E-18
3 SGTC_138 0850-0259 7.89 40.9 µM 1.48E-13 cell wall 64 1.49E-15
4 SGTC_2565 isoliquiritigenin 7.33 100.0 µM 6.40E-12 6 1.14E-13
5 SGTC_3123 9126162 5.59 49.5 µM 1.39E-7 4 1.16E-8
6 SGTC_304 1310-0298 5.54 97.0 µM 1.80E-7 cell wall 25 1.55E-8
7 SGTC_528 3492-0019 5.53 172.0 µM 1.84E-7 calcium & mitochondrial duress 137 1.59E-8
8 SGTC_1015 4130-4525 5.49 82.0 µM 2.29E-7 60S ribosome export 5 2.05E-8
9 SGTC_690 glyoxal 5.37 20.3 µM 4.00E-7 56 3.91E-8
10 SGTC_3132 9126706 5.28 49.5 µM 6.27E-7 6 6.56E-8
11 SGTC_2619 obliquin 5.25 87.9 µM 7.09E-7 cell wall 91 7.57E-8
12 SGTC_369 0957-0393 5.25 4.5 µM 7.13E-7 cell wall signaling 8 7.62E-8
13 SGTC_75 0159-0059 5.25 199.0 µM 7.26E-7 fatty acid desaturase (OLE1) 10 7.78E-8
14 SGTC_50 0929-0078 5.18 56.4 µM 9.83E-7 28 1.10E-7
15 SGTC_863 0466-0191 5.08 129.0 µM 1.55E-6 cell wall 43 1.87E-7
16 SGTC_2613 3',4'-dimethoxydalbergione 5.05 24.6 µM 1.76E-6 6 2.17E-7
17 SGTC_1336 1486-0901 4.82 104.0 µM 4.88E-6 12 7.03E-7
18 SGTC_3128 9127691 4.79 49.5 µM 5.57E-6 9 8.20E-7
19 SGTC_1495 4469-0029 4.70 237.0 µM 8.20E-6 81 1.28E-6
20 SGTC_1337 1486-1011 4.65 40.3 µM 1.05E-5 8 1.70E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.442 2.06E-160 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.432 8.16E-153 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.391 8.07E-123 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.390 5.35E-122 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.377 1.73E-113 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.348 2.47E-96 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.344 1.07E-93 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.339 4.30E-91 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.336 3.34E-89 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.336 4.76E-89 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.332 5.87E-87 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.326 5.55E-84 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.326 5.69E-84 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.316 6.79E-79 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.315 6.19E-78 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria