YKL035W / UGP1

UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL035W / UGP1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.09|P-value:7.49E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:3.23|P-value:4.51E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.87|P-value:2.77E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.43|P-value:2.58E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:3.56|P-value:1.26E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:5.09|P-value:8.33E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:3.31|P-value:3.31E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.79|P-value:4.89E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:3.58|P-value:1.17E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.60|P-value:4.53E-9 ID:SGTC_553|Compound:k007-0256|FD-Score:3.01|P-value:9.70E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.38|P-value:2.86E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.15|P-value:6.58E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.91|P-value:2.87E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.94|P-value:2.53E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.28|P-value:3.66E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-4.24|P-value:7.46E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:3.47|P-value:1.82E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.38|P-value:2.81E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-3.16|P-value:6.43E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:8.23|P-value:1.51E-17 ID:SGTC_872|Compound:0588-0139|FD-Score:3.53|P-value:1.43E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.89|P-value:3.16E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.81|P-value:3.88E-7 ID:SGTC_943|Compound:3253-1379|FD-Score:4.07|P-value:1.43E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.05|P-value:9.50E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.70|P-value:7.86E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.40|P-value:2.68E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.28|P-value:2.87E-8 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.48|P-value:1.75E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.54|P-value:1.36E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.48|P-value:1.70E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.60|P-value:1.16E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.20|P-value:4.89E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.11|P-value:6.97E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.08|P-value:7.66E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.51|P-value:1.54E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.80|P-value:4.64E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.71|P-value:7.55E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.88|P-value:3.76E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.30|P-value:4.84E-11 ID:SGTC_1682|Compound:st012968|FD-Score:-3.85|P-value:4.35E-5 ID:SGTC_1703|Compound:st026983|FD-Score:-3.28|P-value:4.09E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.47|P-value:1.78E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.62|P-value:9.78E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-7.86|P-value:4.53E-16 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.49|P-value:1.65E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-4.14|P-value:1.22E-5 ID:SGTC_1882|Compound:5615643|FD-Score:3.96|P-value:2.37E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.10|P-value:7.11E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.36|P-value:2.70E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.84|P-value:3.94E-5 ID:SGTC_2299|Compound:7976368|FD-Score:-3.31|P-value:3.67E-4 ID:SGTC_2330|Compound:7979373|FD-Score:5.15|P-value:6.03E-8 ID:SGTC_2333|Compound:9017922|FD-Score:3.13|P-value:6.42E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.17|P-value:9.30E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.43|P-value:2.33E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:13.10|P-value:1.48E-41 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.77|P-value:6.03E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.63|P-value:1.07E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.01|P-value:1.33E-7 ID:SGTC_2710|Compound:st078562|FD-Score:-3.93|P-value:3.00E-5 ID:SGTC_2712|Compound:st079126|FD-Score:-4.64|P-value:1.06E-6 ID:SGTC_2713|Compound:st079149|FD-Score:6.45|P-value:1.79E-11 ID:SGTC_2715|Compound:st079500|FD-Score:-3.59|P-value:1.26E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.02|P-value:1.78E-5 ID:SGTC_2819|Compound:7996655|FD-Score:3.93|P-value:2.70E-5 ID:SGTC_2831|Compound:7999036|FD-Score:4.37|P-value:3.48E-6 ID:SGTC_2837|Compound:9008476|FD-Score:6.15|P-value:1.35E-10 ID:SGTC_2854|Compound:9024559|FD-Score:4.56|P-value:1.43E-6 ID:SGTC_2873|Compound:9040596|FD-Score:3.04|P-value:8.91E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.85|P-value:4.36E-5 ID:SGTC_2939|Compound:9044578|FD-Score:4.02|P-value:1.80E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.35|P-value:2.80E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.18|P-value:5.36E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.75|P-value:6.62E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.24|P-value:4.34E-4 ID:SGTC_3241|Compound:9133421|FD-Score:3.01|P-value:9.73E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.28|P-value:5.46E-6 ID:SGTC_3321|Compound:9137793|FD-Score:4.15|P-value:9.80E-6 ID:SGTC_3327|Compound:9140648|FD-Score:3.08|P-value:7.69E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.09|P-value:7.49E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:3.23|P-value:4.51E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.87|P-value:2.77E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.43|P-value:2.58E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:3.56|P-value:1.26E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:5.09|P-value:8.33E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:3.31|P-value:3.31E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.79|P-value:4.89E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:3.58|P-value:1.17E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.60|P-value:4.53E-9 ID:SGTC_553|Compound:k007-0256|FD-Score:3.01|P-value:9.70E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.38|P-value:2.86E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.15|P-value:6.58E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.91|P-value:2.87E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.94|P-value:2.53E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.28|P-value:3.66E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-4.24|P-value:7.46E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:3.47|P-value:1.82E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.38|P-value:2.81E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-3.16|P-value:6.43E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:8.23|P-value:1.51E-17 ID:SGTC_872|Compound:0588-0139|FD-Score:3.53|P-value:1.43E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.89|P-value:3.16E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.81|P-value:3.88E-7 ID:SGTC_943|Compound:3253-1379|FD-Score:4.07|P-value:1.43E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.05|P-value:9.50E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.70|P-value:7.86E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.40|P-value:2.68E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.28|P-value:2.87E-8 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.48|P-value:1.75E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.54|P-value:1.36E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.48|P-value:1.70E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.60|P-value:1.16E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.20|P-value:4.89E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.11|P-value:6.97E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.08|P-value:7.66E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.51|P-value:1.54E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.80|P-value:4.64E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.71|P-value:7.55E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.88|P-value:3.76E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.30|P-value:4.84E-11 ID:SGTC_1682|Compound:st012968|FD-Score:-3.85|P-value:4.35E-5 ID:SGTC_1703|Compound:st026983|FD-Score:-3.28|P-value:4.09E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.47|P-value:1.78E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.62|P-value:9.78E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-7.86|P-value:4.53E-16 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.49|P-value:1.65E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-4.14|P-value:1.22E-5 ID:SGTC_1882|Compound:5615643|FD-Score:3.96|P-value:2.37E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.10|P-value:7.11E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.36|P-value:2.70E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.84|P-value:3.94E-5 ID:SGTC_2299|Compound:7976368|FD-Score:-3.31|P-value:3.67E-4 ID:SGTC_2330|Compound:7979373|FD-Score:5.15|P-value:6.03E-8 ID:SGTC_2333|Compound:9017922|FD-Score:3.13|P-value:6.42E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.17|P-value:9.30E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.43|P-value:2.33E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:13.10|P-value:1.48E-41 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.77|P-value:6.03E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.63|P-value:1.07E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.01|P-value:1.33E-7 ID:SGTC_2710|Compound:st078562|FD-Score:-3.93|P-value:3.00E-5 ID:SGTC_2712|Compound:st079126|FD-Score:-4.64|P-value:1.06E-6 ID:SGTC_2713|Compound:st079149|FD-Score:6.45|P-value:1.79E-11 ID:SGTC_2715|Compound:st079500|FD-Score:-3.59|P-value:1.26E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.02|P-value:1.78E-5 ID:SGTC_2819|Compound:7996655|FD-Score:3.93|P-value:2.70E-5 ID:SGTC_2831|Compound:7999036|FD-Score:4.37|P-value:3.48E-6 ID:SGTC_2837|Compound:9008476|FD-Score:6.15|P-value:1.35E-10 ID:SGTC_2854|Compound:9024559|FD-Score:4.56|P-value:1.43E-6 ID:SGTC_2873|Compound:9040596|FD-Score:3.04|P-value:8.91E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.85|P-value:4.36E-5 ID:SGTC_2939|Compound:9044578|FD-Score:4.02|P-value:1.80E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.35|P-value:2.80E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.18|P-value:5.36E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.75|P-value:6.62E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.24|P-value:4.34E-4 ID:SGTC_3241|Compound:9133421|FD-Score:3.01|P-value:9.73E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.28|P-value:5.46E-6 ID:SGTC_3321|Compound:9137793|FD-Score:4.15|P-value:9.80E-6 ID:SGTC_3327|Compound:9140648|FD-Score:3.08|P-value:7.69E-4

Top fitness defect scores for YKL035W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2584 androsterone 13.10 48.7 µM 1.48E-41 cell wall 1 1.27E-39 2.77
2 SGTC_863 0466-0191 8.23 129.0 µM 1.51E-17 cell wall 7 9.27E-17 0.91
3 SGTC_2713 st079149 6.45 53.4 µM 1.79E-11 1 5.64E-11 2.01
4 SGTC_1597 7-benzyloxygramine 6.30 47.5 µM 4.84E-11 calcium & mitochondrial duress 31 1.45E-10 0.11
5 SGTC_2837 9008476 6.15 45.5 µM 1.35E-10 3 3.85E-10 2.19
6 SGTC_514 4466-0038 5.60 2.6 nM 4.53E-9 cell wall 21 1.09E-8 0.12
7 SGTC_1057 3448-5381 5.28 134.0 µM 2.87E-8 calcium & mitochondrial duress 8 6.34E-8 0.25
8 SGTC_2330 7979373 5.15 200.0 µM 6.03E-8 60S ribosome export 5 1.28E-7 0.82
9 SGTC_164 4100-3994 5.09 89.6 µM 8.33E-8 4 1.75E-7 0.93
10 SGTC_2619 obliquin 5.01 87.9 µM 1.33E-7 cell wall 25 2.74E-7 0.07
11 SGTC_94 0334-0113 4.87 514.8 µM 2.77E-7 2 5.49E-7 0.76
12 SGTC_916 4466-0038 4.81 42.0 nM 3.88E-7 cell wall 19 7.56E-7 0.01
13 SGTC_1464 k208-0027 4.60 110.0 µM 1.16E-6 3 2.14E-6 0.14
14 SGTC_2854 9024559 4.56 71.4 µM 1.43E-6 5 2.62E-6 0.69
15 SGTC_2831 7999036 4.37 19.5 µM 3.48E-6 3 6.10E-6 0.20
16 SGTC_3311 9131146 4.28 2.9 µM 5.46E-6 cell wall 17 9.38E-6 0.01
17 SGTC_2367 9070478 4.17 135.4 µM 9.30E-6 cell wall 9 1.56E-5 0.26
18 SGTC_3321 9137793 4.15 26.8 µM 9.80E-6 cell wall 17 1.64E-5 0.34
19 SGTC_943 3253-1379 4.07 105.0 µM 1.43E-5 6 2.35E-5 0.13
20 SGTC_2768 sulfasalazine 4.02 50.2 µM 1.78E-5 7 2.89E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.320 1.00E-80 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.312 7.52E-77 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.306 9.58E-74 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.283 8.80E-63 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.262 1.40E-53 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.259 1.07E-52 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.257 7.37E-52 YMR273C ZDS1 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
0.251 2.33E-49 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.249 1.04E-48 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
0.247 6.34E-48 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.246 2.24E-47 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.245 3.57E-47 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.241 1.98E-45 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.239 9.52E-45 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.234 5.58E-43 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies