YKL036C_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL036C / YKL036C

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.16|P-value:5.70E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-9.65|P-value:2.10E-23 ID:SGTC_153|Compound:4077-0274|FD-Score:3.20|P-value:4.92E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.18|P-value:5.23E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.09|P-value:7.16E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.51|P-value:1.72E-6 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.03|P-value:9.65E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.73|P-value:1.88E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:3.13|P-value:6.28E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.52|P-value:1.44E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.45|P-value:1.92E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-3.68|P-value:8.19E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:10.10|P-value:1.70E-25 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.41|P-value:2.26E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.06|P-value:8.23E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.76|P-value:5.39E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.31|P-value:3.21E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.10|P-value:7.06E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.13|P-value:6.32E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.10|P-value:7.10E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.20|P-value:4.99E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.08|P-value:7.66E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.33|P-value:3.02E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.64|P-value:9.16E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.16|P-value:6.05E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.15|P-value:5.91E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.15|P-value:5.82E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.53|P-value:1.57E-6 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.40|P-value:2.29E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.20|P-value:7.53E-6 ID:SGTC_1832|Compound:st054113|FD-Score:-3.16|P-value:6.02E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.13|P-value:1.09E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-3.24|P-value:4.47E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.78|P-value:4.42E-7 ID:SGTC_1859|Compound:st055998|FD-Score:-3.56|P-value:1.32E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.09|P-value:7.41E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.83|P-value:4.31E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-4.00|P-value:2.05E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.72|P-value:6.45E-5 ID:SGTC_2087|Compound:5276107|FD-Score:4.88|P-value:2.53E-7 ID:SGTC_2093|Compound:5331342|FD-Score:3.22|P-value:4.51E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.19|P-value:7.92E-6 ID:SGTC_2171|Compound:5739187|FD-Score:-3.38|P-value:2.64E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.40|P-value:2.30E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.17|P-value:5.45E-4 ID:SGTC_2482|Compound:5981709|FD-Score:5.21|P-value:4.11E-8 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.79|P-value:4.78E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.53|P-value:6.54E-9 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.29|P-value:3.80E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:8.08|P-value:4.86E-17 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.47|P-value:1.77E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-4.44|P-value:2.65E-6 ID:SGTC_2888|Compound:9058547|FD-Score:3.10|P-value:6.99E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.40|P-value:3.31E-6 ID:SGTC_3118|Compound:9124250|FD-Score:4.09|P-value:1.25E-5 ID:SGTC_3248|Compound:9135562|FD-Score:3.39|P-value:2.42E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.16|P-value:5.70E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-9.65|P-value:2.10E-23 ID:SGTC_153|Compound:4077-0274|FD-Score:3.20|P-value:4.92E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.18|P-value:5.23E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.09|P-value:7.16E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.51|P-value:1.72E-6 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.03|P-value:9.65E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.73|P-value:1.88E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:3.13|P-value:6.28E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.52|P-value:1.44E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.45|P-value:1.92E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-3.68|P-value:8.19E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:10.10|P-value:1.70E-25 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.41|P-value:2.26E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.06|P-value:8.23E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.76|P-value:5.39E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.31|P-value:3.21E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.10|P-value:7.06E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.13|P-value:6.32E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.10|P-value:7.10E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.20|P-value:4.99E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.08|P-value:7.66E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.33|P-value:3.02E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.64|P-value:9.16E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.16|P-value:6.05E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.15|P-value:5.91E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.15|P-value:5.82E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.53|P-value:1.57E-6 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.40|P-value:2.29E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.20|P-value:7.53E-6 ID:SGTC_1832|Compound:st054113|FD-Score:-3.16|P-value:6.02E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.13|P-value:1.09E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-3.24|P-value:4.47E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.78|P-value:4.42E-7 ID:SGTC_1859|Compound:st055998|FD-Score:-3.56|P-value:1.32E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.09|P-value:7.41E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.83|P-value:4.31E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-4.00|P-value:2.05E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.72|P-value:6.45E-5 ID:SGTC_2087|Compound:5276107|FD-Score:4.88|P-value:2.53E-7 ID:SGTC_2093|Compound:5331342|FD-Score:3.22|P-value:4.51E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.19|P-value:7.92E-6 ID:SGTC_2171|Compound:5739187|FD-Score:-3.38|P-value:2.64E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.40|P-value:2.30E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.17|P-value:5.45E-4 ID:SGTC_2482|Compound:5981709|FD-Score:5.21|P-value:4.11E-8 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.79|P-value:4.78E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.53|P-value:6.54E-9 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.29|P-value:3.80E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:8.08|P-value:4.86E-17 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.47|P-value:1.77E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-4.44|P-value:2.65E-6 ID:SGTC_2888|Compound:9058547|FD-Score:3.10|P-value:6.99E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.40|P-value:3.31E-6 ID:SGTC_3118|Compound:9124250|FD-Score:4.09|P-value:1.25E-5 ID:SGTC_3248|Compound:9135562|FD-Score:3.39|P-value:2.42E-4

Top fitness defect scores for YKL036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_863 0466-0191 10.10 129.0 µM 1.70E-25 cell wall 3 3.15E-24 1.21
2 SGTC_2619 obliquin 8.08 87.9 µM 4.86E-17 cell wall 7 3.24E-16 0.12
3 SGTC_514 4466-0038 5.73 2.6 nM 1.88E-9 cell wall 19 5.03E-9 0.06
4 SGTC_2584 androsterone 5.53 48.7 µM 6.54E-9 cell wall 15 1.64E-8 0.22
5 SGTC_2482 5981709 5.21 142.7 µM 4.11E-8 PDR1 5 9.36E-8 0.05
6 SGTC_2087 5276107 4.88 200.0 µM 2.53E-7 1 5.24E-7 0.27
7 SGTC_1855 st056195 4.78 39.6 µM 4.42E-7 60S ribosome export 4 8.89E-7 0.11
8 SGTC_1495 4469-0029 4.64 237.0 µM 9.16E-7 2 1.78E-6 0.34
9 SGTC_1550 gossypolone 4.53 36.6 µM 1.57E-6 2 2.95E-6 0.16
10 SGTC_304 1310-0298 4.51 97.0 µM 1.72E-6 cell wall 5 3.23E-6 0.43
11 SGTC_1773 st048542 4.20 73.6 µM 7.53E-6 22 1.31E-5 0.10
12 SGTC_2104 5389443 4.19 200.0 µM 7.92E-6 3 1.37E-5 0.11
13 SGTC_1844 rapamycin 4.13 4.0 nM 1.09E-5 48 1.85E-5 0.06
14 SGTC_3118 9124250 4.09 49.5 µM 1.25E-5 5 2.12E-5 0.17
15 SGTC_2514 salinomycin 3.79 42.7 µM 4.78E-5 4 7.56E-5 0.28
16 SGTC_974 1326-0144 3.76 138.0 µM 5.39E-5 ERG2 9 8.46E-5 0.13
17 SGTC_2061 5245884 3.72 81.0 µM 6.45E-5 tubulin folding & SWR complex 8 1.00E-4 0.00
18 SGTC_666 0272-0154 3.52 136.0 µM 1.44E-4 cell wall 20 2.14E-4 0.03
19 SGTC_2752 diclazuril 3.47 33.1 µM 1.77E-4 13 2.61E-4 1.87E-4
20 SGTC_690 glyoxal 3.45 20.3 µM 1.92E-4 33 2.83E-4 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.264 1.13E-54 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.249 1.04E-48 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.226 6.56E-40 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.217 6.41E-37 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.216 1.59E-36 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.210 9.18E-35 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.210 1.26E-34 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.208 4.94E-34 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.199 2.29E-31 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.199 3.08E-31 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.197 8.19E-31 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.195 3.66E-30 YER133W GLC7 het Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
0.194 8.13E-30 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.191 5.42E-29 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.190 1.59E-28 YKL114C APN1 hom Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine