YKL037W / AIM26

Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL037W / AIM26

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:4.01|P-value:2.14E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.02|P-value:5.20E-8 ID:SGTC_122|Compound:0236-0016|FD-Score:4.18|P-value:1.18E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.82|P-value:3.92E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:5.60|P-value:3.75E-7 ID:SGTC_207|Compound:4185-0010|FD-Score:3.92|P-value:2.85E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.98|P-value:5.69E-6 ID:SGTC_397|Compound:arbidol|FD-Score:4.46|P-value:4.32E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:3.87|P-value:3.38E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.93|P-value:1.73E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.55|P-value:3.02E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:5.93|P-value:7.97E-8 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.83|P-value:3.91E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.88|P-value:3.30E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.85|P-value:3.66E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.09|P-value:1.64E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.67|P-value:6.44E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.66|P-value:6.67E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.05|P-value:1.84E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.78|P-value:1.25E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:4.39|P-value:5.64E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:3.91|P-value:2.92E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:6.64|P-value:2.08E-9 ID:SGTC_711|Compound:k292-0785|FD-Score:4.13|P-value:1.40E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.73|P-value:5.28E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:4.33|P-value:6.99E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:4.24|P-value:9.53E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:10.00|P-value:2.59E-19 ID:SGTC_878|Compound:0828-0289|FD-Score:4.53|P-value:3.34E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.56|P-value:4.46E-7 ID:SGTC_923|Compound:1900-2434|FD-Score:10.20|P-value:6.73E-20 ID:SGTC_928|Compound:2764-0428|FD-Score:12.30|P-value:3.77E-28 ID:SGTC_948|Compound:3448-0295|FD-Score:5.34|P-value:1.22E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:4.58|P-value:2.70E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:6.21|P-value:1.97E-8 ID:SGTC_995|Compound:3931-2021|FD-Score:4.63|P-value:2.30E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.08|P-value:1.01E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.03|P-value:1.99E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.72|P-value:2.20E-7 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.75|P-value:4.96E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:6.42|P-value:6.74E-9 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.73|P-value:1.53E-5 ID:SGTC_1759|Compound:st043059|FD-Score:5.84|P-value:1.20E-7 ID:SGTC_1959|Compound:st077091|FD-Score:5.85|P-value:1.17E-7 ID:SGTC_2009|Compound:4012297|FD-Score:7.75|P-value:3.26E-12 ID:SGTC_2010|Compound:4012422|FD-Score:3.80|P-value:4.31E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.73|P-value:1.55E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.85|P-value:3.66E-4 ID:SGTC_2123|Compound:5259487|FD-Score:5.69|P-value:2.50E-7 ID:SGTC_2239|Compound:6685329|FD-Score:-7.52|P-value:5.33E-12 ID:SGTC_2245|Compound:6637752|FD-Score:-5.40|P-value:4.89E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.04|P-value:4.44E-6 ID:SGTC_2256|Compound:7954252|FD-Score:-4.71|P-value:9.20E-6 ID:SGTC_2313|Compound:7726885|FD-Score:6.47|P-value:5.15E-9 ID:SGTC_2314|Compound:7727897|FD-Score:3.69|P-value:6.03E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.83|P-value:3.90E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.24|P-value:5.78E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.69|P-value:5.97E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.21|P-value:1.06E-4 ID:SGTC_2382|Compound:9035899|FD-Score:6.49|P-value:4.52E-9 ID:SGTC_2393|Compound:9031399|FD-Score:3.90|P-value:3.03E-4 ID:SGTC_2439|Compound:5492030|FD-Score:5.65|P-value:3.04E-7 ID:SGTC_2443|Compound:5493264|FD-Score:3.76|P-value:4.76E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.17|P-value:1.21E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.76|P-value:2.99E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.38|P-value:1.03E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:6.47|P-value:5.09E-9 ID:SGTC_2619|Compound:obliquin|FD-Score:9.73|P-value:2.79E-18 ID:SGTC_2781|Compound:5567276|FD-Score:-4.08|P-value:1.02E-4 ID:SGTC_2798|Compound:7813637|FD-Score:6.48|P-value:4.90E-9 ID:SGTC_2820|Compound:7989630|FD-Score:3.80|P-value:4.31E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-4.25|P-value:5.52E-5 ID:SGTC_2836|Compound:9010338|FD-Score:5.30|P-value:1.43E-6 ID:SGTC_2845|Compound:9003024|FD-Score:6.86|P-value:6.05E-10 ID:SGTC_2893|Compound:9048488|FD-Score:5.21|P-value:2.13E-6 ID:SGTC_2897|Compound:9048598|FD-Score:5.05|P-value:4.16E-6 ID:SGTC_2950|Compound:9072895|FD-Score:3.73|P-value:5.33E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.94|P-value:2.65E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.86|P-value:3.50E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.56|P-value:4.48E-7 ID:SGTC_3321|Compound:9137793|FD-Score:3.68|P-value:6.12E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.64|P-value:2.20E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:4.01|P-value:2.14E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.02|P-value:5.20E-8 ID:SGTC_122|Compound:0236-0016|FD-Score:4.18|P-value:1.18E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.82|P-value:3.92E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:5.60|P-value:3.75E-7 ID:SGTC_207|Compound:4185-0010|FD-Score:3.92|P-value:2.85E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.98|P-value:5.69E-6 ID:SGTC_397|Compound:arbidol|FD-Score:4.46|P-value:4.32E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:3.87|P-value:3.38E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.93|P-value:1.73E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.55|P-value:3.02E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:5.93|P-value:7.97E-8 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.83|P-value:3.91E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.88|P-value:3.30E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.85|P-value:3.66E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.09|P-value:1.64E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.67|P-value:6.44E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.66|P-value:6.67E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.05|P-value:1.84E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.78|P-value:1.25E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:4.39|P-value:5.64E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:3.91|P-value:2.92E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:6.64|P-value:2.08E-9 ID:SGTC_711|Compound:k292-0785|FD-Score:4.13|P-value:1.40E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.73|P-value:5.28E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:4.33|P-value:6.99E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:4.24|P-value:9.53E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:10.00|P-value:2.59E-19 ID:SGTC_878|Compound:0828-0289|FD-Score:4.53|P-value:3.34E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.56|P-value:4.46E-7 ID:SGTC_923|Compound:1900-2434|FD-Score:10.20|P-value:6.73E-20 ID:SGTC_928|Compound:2764-0428|FD-Score:12.30|P-value:3.77E-28 ID:SGTC_948|Compound:3448-0295|FD-Score:5.34|P-value:1.22E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:4.58|P-value:2.70E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:6.21|P-value:1.97E-8 ID:SGTC_995|Compound:3931-2021|FD-Score:4.63|P-value:2.30E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.08|P-value:1.01E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.03|P-value:1.99E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.72|P-value:2.20E-7 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.75|P-value:4.96E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:6.42|P-value:6.74E-9 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.73|P-value:1.53E-5 ID:SGTC_1759|Compound:st043059|FD-Score:5.84|P-value:1.20E-7 ID:SGTC_1959|Compound:st077091|FD-Score:5.85|P-value:1.17E-7 ID:SGTC_2009|Compound:4012297|FD-Score:7.75|P-value:3.26E-12 ID:SGTC_2010|Compound:4012422|FD-Score:3.80|P-value:4.31E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.73|P-value:1.55E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.85|P-value:3.66E-4 ID:SGTC_2123|Compound:5259487|FD-Score:5.69|P-value:2.50E-7 ID:SGTC_2239|Compound:6685329|FD-Score:-7.52|P-value:5.33E-12 ID:SGTC_2245|Compound:6637752|FD-Score:-5.40|P-value:4.89E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.04|P-value:4.44E-6 ID:SGTC_2256|Compound:7954252|FD-Score:-4.71|P-value:9.20E-6 ID:SGTC_2313|Compound:7726885|FD-Score:6.47|P-value:5.15E-9 ID:SGTC_2314|Compound:7727897|FD-Score:3.69|P-value:6.03E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.83|P-value:3.90E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.24|P-value:5.78E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.69|P-value:5.97E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.21|P-value:1.06E-4 ID:SGTC_2382|Compound:9035899|FD-Score:6.49|P-value:4.52E-9 ID:SGTC_2393|Compound:9031399|FD-Score:3.90|P-value:3.03E-4 ID:SGTC_2439|Compound:5492030|FD-Score:5.65|P-value:3.04E-7 ID:SGTC_2443|Compound:5493264|FD-Score:3.76|P-value:4.76E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.17|P-value:1.21E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.76|P-value:2.99E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.38|P-value:1.03E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:6.47|P-value:5.09E-9 ID:SGTC_2619|Compound:obliquin|FD-Score:9.73|P-value:2.79E-18 ID:SGTC_2781|Compound:5567276|FD-Score:-4.08|P-value:1.02E-4 ID:SGTC_2798|Compound:7813637|FD-Score:6.48|P-value:4.90E-9 ID:SGTC_2820|Compound:7989630|FD-Score:3.80|P-value:4.31E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-4.25|P-value:5.52E-5 ID:SGTC_2836|Compound:9010338|FD-Score:5.30|P-value:1.43E-6 ID:SGTC_2845|Compound:9003024|FD-Score:6.86|P-value:6.05E-10 ID:SGTC_2893|Compound:9048488|FD-Score:5.21|P-value:2.13E-6 ID:SGTC_2897|Compound:9048598|FD-Score:5.05|P-value:4.16E-6 ID:SGTC_2950|Compound:9072895|FD-Score:3.73|P-value:5.33E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.94|P-value:2.65E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.86|P-value:3.50E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.56|P-value:4.48E-7 ID:SGTC_3321|Compound:9137793|FD-Score:3.68|P-value:6.12E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.64|P-value:2.20E-5

Top fitness defect scores for YKL037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_928 2764-0428 12.30 58.7 µM 3.77E-28 cell wall 1 4.79E-35
2 SGTC_923 1900-2434 10.20 73.3 µM 6.73E-20 RNA processing & uracil transport 2 1.07E-24
3 SGTC_863 0466-0191 10.00 129.0 µM 2.59E-19 cell wall 12 5.82E-24
4 SGTC_2619 obliquin 9.73 87.9 µM 2.79E-18 cell wall 24 1.15E-22
5 SGTC_2009 4012297 7.75 12.1 µM 3.26E-12 cell wall signaling 15 4.73E-15
6 SGTC_2845 9003024 6.86 43.0 µM 6.05E-10 amide catabolism 10 3.33E-12
7 SGTC_632 0781-2353 6.64 4.7 µM 2.08E-9 Golgi 8 1.57E-11
8 SGTC_2382 9035899 6.49 200.0 µM 4.52E-9 60S ribosome export 2 4.16E-11
9 SGTC_2798 7813637 6.48 45.5 µM 4.90E-9 4 4.60E-11
10 SGTC_2584 androsterone 6.47 48.7 µM 5.09E-9 cell wall 48 4.82E-11
11 SGTC_2313 7726885 6.47 200.0 µM 5.15E-9 RPP1 & pyrimidine depletion 3 4.89E-11
12 SGTC_1402 3909-7673 6.42 35.9 µM 6.74E-9 2 6.86E-11
13 SGTC_957 1187-1561 6.21 14.1 µM 1.97E-8 3 2.64E-10
14 SGTC_102 gallobenzophenone 6.02 83.6 µM 5.20E-8 redox potentiating 13 8.92E-10
15 SGTC_486 niguldipine 5.93 82.0 µM 7.97E-8 amide catabolism 7 1.53E-9
16 SGTC_1959 st077091 5.85 55.8 µM 1.17E-7 RPP1 & pyrimidine depletion 10 2.46E-9
17 SGTC_1759 st043059 5.84 70.0 µM 1.20E-7 amide catabolism 4 2.54E-9
18 SGTC_1263 0774-1208 5.72 64.8 µM 2.20E-7 9 5.46E-9
19 SGTC_2123 5259487 5.69 200.0 µM 2.50E-7 4 6.40E-9
20 SGTC_2439 5492030 5.65 7.2 µM 3.04E-7 3 8.19E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 6.20E-43 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.231 6.51E-42 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.218 2.22E-37 YER133W GLC7 het Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
0.211 5.07E-35 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.206 1.92E-33 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.204 6.40E-33 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.201 6.68E-32 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.193 1.83E-29 YDR293C SSD1 hom Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function
0.190 1.09E-28 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.184 4.67E-27 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.181 4.64E-26 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.178 2.82E-25 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.171 1.95E-23 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.166 3.65E-22 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.165 7.70E-22 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p