YKL038W / RGT1

Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL038W / RGT1

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.31|P-value:8.98E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.43|P-value:6.46E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.22|P-value:1.23E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:-4.19|P-value:1.48E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.62|P-value:8.35E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.66|P-value:7.41E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:5.20|P-value:3.20E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.55|P-value:0.00100 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.37|P-value:7.34E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:5.11|P-value:4.55E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:3.98|P-value:2.73E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.76|P-value:1.80E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:3.88|P-value:3.69E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:4.34|P-value:8.10E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:6.77|P-value:2.06E-9 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.56|P-value:9.76E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.91|P-value:3.43E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.97|P-value:2.77E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.75|P-value:5.59E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.21|P-value:1.27E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:5.32|P-value:1.89E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.13|P-value:1.66E-4 ID:SGTC_1730|Compound:st033808|FD-Score:7.99|P-value:2.10E-12 ID:SGTC_1868|Compound:st057644|FD-Score:3.75|P-value:5.59E-4 ID:SGTC_1948|Compound:st076329|FD-Score:7.80|P-value:6.54E-12 ID:SGTC_1949|Compound:st076024|FD-Score:-4.93|P-value:1.01E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-4.29|P-value:1.05E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.99|P-value:2.84E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.70|P-value:7.02E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.60|P-value:9.26E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.53|P-value:4.19E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.86|P-value:1.22E-5 ID:SGTC_2701|Compound:st077767|FD-Score:4.38|P-value:7.07E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.96|P-value:2.92E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-4.68|P-value:2.63E-5 ID:SGTC_2923|Compound:7992654|FD-Score:4.07|P-value:2.01E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.00|P-value:7.10E-6 ID:SGTC_3161|Compound:9100388|FD-Score:4.10|P-value:1.85E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-5.76|P-value:3.19E-7 ID:SGTC_3269|Compound:9137823|FD-Score:3.63|P-value:7.90E-4 ID:SGTC_3275|Compound:9138069|FD-Score:3.64|P-value:7.81E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.31|P-value:8.98E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.43|P-value:6.46E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.22|P-value:1.23E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:-4.19|P-value:1.48E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.62|P-value:8.35E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.66|P-value:7.41E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:5.20|P-value:3.20E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.55|P-value:0.00100 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.37|P-value:7.34E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:5.11|P-value:4.55E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:3.98|P-value:2.73E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.76|P-value:1.80E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:3.88|P-value:3.69E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:4.34|P-value:8.10E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:6.77|P-value:2.06E-9 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.56|P-value:9.76E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.91|P-value:3.43E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.97|P-value:2.77E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.75|P-value:5.59E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.21|P-value:1.27E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:5.32|P-value:1.89E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.13|P-value:1.66E-4 ID:SGTC_1730|Compound:st033808|FD-Score:7.99|P-value:2.10E-12 ID:SGTC_1868|Compound:st057644|FD-Score:3.75|P-value:5.59E-4 ID:SGTC_1948|Compound:st076329|FD-Score:7.80|P-value:6.54E-12 ID:SGTC_1949|Compound:st076024|FD-Score:-4.93|P-value:1.01E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-4.29|P-value:1.05E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.99|P-value:2.84E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.70|P-value:7.02E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.60|P-value:9.26E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.53|P-value:4.19E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.86|P-value:1.22E-5 ID:SGTC_2701|Compound:st077767|FD-Score:4.38|P-value:7.07E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.96|P-value:2.92E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-4.68|P-value:2.63E-5 ID:SGTC_2923|Compound:7992654|FD-Score:4.07|P-value:2.01E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.00|P-value:7.10E-6 ID:SGTC_3161|Compound:9100388|FD-Score:4.10|P-value:1.85E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-5.76|P-value:3.19E-7 ID:SGTC_3269|Compound:9137823|FD-Score:3.63|P-value:7.90E-4 ID:SGTC_3275|Compound:9138069|FD-Score:3.64|P-value:7.81E-4

Top fitness defect scores for YKL038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1730 st033808 7.99 45.1 µM 2.10E-12 3 7.00E-16
2 SGTC_1948 st076329 7.80 66.6 µM 6.54E-12 1 3.15E-15
3 SGTC_946 3434-1334 6.77 87.4 µM 2.06E-9 4 6.31E-12
4 SGTC_1385 3091-4834 5.32 14.1 µM 1.89E-6 RPP1 & pyrimidine depletion 2 5.08E-8
5 SGTC_390 dec-rvkr-cmk 5.20 16.7 µM 3.20E-6 calcium & mitochondrial duress 7 1.02E-7
6 SGTC_557 1315-0110 5.11 16.2 µM 4.55E-6 Golgi 3 1.62E-7
7 SGTC_2928 9011484 5.00 9.8 µM 7.10E-6 heme biosynthesis & mitochondrial translocase 17 2.90E-7
8 SGTC_2597 laccaic acid a 4.86 100.0 µM 1.22E-5 16 5.92E-7
9 SGTC_700 3453-2283 4.76 142.0 µM 1.80E-5 amide catabolism 10 9.87E-7
10 SGTC_2552 juarezic acid 4.53 87.0 µM 4.19E-5 TSC3-RPN4 21 2.99E-6
11 SGTC_2701 st077767 4.38 14.7 µM 7.07E-5 31 5.93E-6
12 SGTC_506 n9-isopropylolomoucine 4.37 153.0 µM 7.34E-5 7 6.22E-6
13 SGTC_941 3237-0776 4.34 460.0 µM 8.10E-5 8 7.08E-6
14 SGTC_45 0kpi-0036 4.31 14.9 µM 8.98E-5 excess fatty acid 14 8.12E-6
15 SGTC_183 3914-0051 4.22 30.6 µM 1.23E-4 60S ribosome export 19 1.23E-5
16 SGTC_1356 1502-0781 4.21 85.8 µM 1.27E-4 fatty acid desaturase (OLE1) 10 1.27E-5
17 SGTC_1562 morin hydrate 4.13 59.1 µM 1.66E-4 12 1.82E-5
18 SGTC_3161 9100388 4.10 49.5 µM 1.85E-4 iron homeostasis 8 2.09E-5
19 SGTC_2923 7992654 4.07 58.1 µM 2.01E-4 Golgi 23 2.33E-5
20 SGTC_649 1123-0311 3.98 367.0 µM 2.73E-4 endomembrane recycling 68 3.48E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.078 6.63E-6 YHR114W BZZ1 hom SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
0.077 7.47E-6 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.077 8.31E-6 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.073 2.46E-5 YLR363W-A YLR363W-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.072 2.76E-5 YDR327W_d YDR327W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
0.069 6.37E-5 YKL142W MRP8 hom Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis
0.069 6.58E-5 YMR083W ADH3 hom Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
0.068 7.25E-5 YPL070W MUK1 hom Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
0.068 8.29E-5 YOL099C_d YOL099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes
0.068 8.33E-5 YBR215W HPC2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes
0.064 2.07E-4 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.064 2.08E-4 YNL255C GIS2 hom Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
0.063 2.54E-4 YIL023C YKE4 hom Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
0.062 3.27E-4 YPR020W ATP20 hom Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
0.062 3.38E-4 YOR042W CUE5 hom Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern