YKL041W / VPS24

One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL041W / VPS24

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.98|P-value:9.52E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:4.86|P-value:2.54E-6 ID:SGTC_25|Compound:0118-0223|FD-Score:3.42|P-value:6.91E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.75|P-value:2.80E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:3.73|P-value:2.42E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.42|P-value:6.89E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.66|P-value:6.15E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:5.23|P-value:4.61E-7 ID:SGTC_150|Compound:3970-0969|FD-Score:3.69|P-value:2.73E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.89|P-value:1.61E-8 ID:SGTC_280|Compound:3448-3607|FD-Score:3.58|P-value:3.96E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.43|P-value:1.39E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.92|P-value:1.71E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.91|P-value:1.75E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.11|P-value:6.98E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.01|P-value:7.53E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:4.78|P-value:3.70E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.65|P-value:3.11E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.30|P-value:9.94E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.66|P-value:3.02E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:4.11|P-value:5.79E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.62|P-value:3.47E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:9.09|P-value:7.04E-18 ID:SGTC_761|Compound:k216-0224|FD-Score:3.47|P-value:5.87E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.45|P-value:1.30E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.84|P-value:1.61E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.57|P-value:3.65E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:5.00|P-value:1.35E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.41|P-value:7.17E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.66|P-value:3.02E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.37|P-value:7.07E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:5.29|P-value:3.50E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:6.60|P-value:2.99E-10 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.65|P-value:2.75E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.34|P-value:8.99E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.32|P-value:9.38E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.61|P-value:3.62E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.94|P-value:1.13E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.60|P-value:2.85E-10 ID:SGTC_1636|Compound:st007707|FD-Score:3.78|P-value:2.03E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.08|P-value:9.38E-7 ID:SGTC_1687|Compound:st020778|FD-Score:5.13|P-value:7.35E-7 ID:SGTC_1711|Compound:st032263|FD-Score:3.42|P-value:6.87E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.76|P-value:2.18E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.35|P-value:8.67E-4 ID:SGTC_1773|Compound:st048542|FD-Score:6.10|P-value:5.14E-9 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.08|P-value:6.52E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.42|P-value:8.60E-10 ID:SGTC_1925|Compound:st057770|FD-Score:7.49|P-value:1.02E-12 ID:SGTC_2009|Compound:4012297|FD-Score:3.70|P-value:2.64E-4 ID:SGTC_2141|Compound:5621638|FD-Score:3.37|P-value:8.07E-4 ID:SGTC_2174|Compound:5790901|FD-Score:5.19|P-value:5.66E-7 ID:SGTC_2178|Compound:5812956|FD-Score:3.62|P-value:3.46E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-12.50|P-value:1.55E-32 ID:SGTC_2253|Compound:7938677|FD-Score:-3.65|P-value:2.79E-4 ID:SGTC_2255|Compound:7941087|FD-Score:7.42|P-value:1.62E-12 ID:SGTC_2321|Compound:7390090|FD-Score:3.94|P-value:1.14E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.43|P-value:1.72E-7 ID:SGTC_2339|Compound:9000433|FD-Score:-3.43|P-value:5.78E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.19|P-value:4.34E-5 ID:SGTC_2452|Compound:5863136|FD-Score:4.88|P-value:2.37E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:5.67|P-value:5.33E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.51|P-value:1.16E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:4.52|P-value:1.15E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.46|P-value:6.05E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.30|P-value:2.84E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.54|P-value:4.54E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.74|P-value:2.33E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.18|P-value:4.48E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.41|P-value:7.02E-4 ID:SGTC_2854|Compound:9024559|FD-Score:4.28|P-value:2.99E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.77|P-value:1.79E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.34|P-value:8.98E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.31|P-value:9.89E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.03|P-value:8.06E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.93|P-value:9.97E-5 ID:SGTC_3181|Compound:9108277|FD-Score:4.00|P-value:8.83E-5 ID:SGTC_3265|Compound:9137266|FD-Score:3.71|P-value:2.58E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.07|P-value:4.89E-9 ID:SGTC_3347|Compound:9188721|FD-Score:-3.43|P-value:5.82E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.98|P-value:9.52E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:4.86|P-value:2.54E-6 ID:SGTC_25|Compound:0118-0223|FD-Score:3.42|P-value:6.91E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.75|P-value:2.80E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:3.73|P-value:2.42E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.42|P-value:6.89E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.66|P-value:6.15E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:5.23|P-value:4.61E-7 ID:SGTC_150|Compound:3970-0969|FD-Score:3.69|P-value:2.73E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.89|P-value:1.61E-8 ID:SGTC_280|Compound:3448-3607|FD-Score:3.58|P-value:3.96E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.43|P-value:1.39E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.92|P-value:1.71E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.91|P-value:1.75E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.11|P-value:6.98E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.01|P-value:7.53E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:4.78|P-value:3.70E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.65|P-value:3.11E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.30|P-value:9.94E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.66|P-value:3.02E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:4.11|P-value:5.79E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.62|P-value:3.47E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:9.09|P-value:7.04E-18 ID:SGTC_761|Compound:k216-0224|FD-Score:3.47|P-value:5.87E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.45|P-value:1.30E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.84|P-value:1.61E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.57|P-value:3.65E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:5.00|P-value:1.35E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.41|P-value:7.17E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.66|P-value:3.02E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.37|P-value:7.07E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:5.29|P-value:3.50E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:6.60|P-value:2.99E-10 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.65|P-value:2.75E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.34|P-value:8.99E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.32|P-value:9.38E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.61|P-value:3.62E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.94|P-value:1.13E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:6.60|P-value:2.85E-10 ID:SGTC_1636|Compound:st007707|FD-Score:3.78|P-value:2.03E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.08|P-value:9.38E-7 ID:SGTC_1687|Compound:st020778|FD-Score:5.13|P-value:7.35E-7 ID:SGTC_1711|Compound:st032263|FD-Score:3.42|P-value:6.87E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.76|P-value:2.18E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.35|P-value:8.67E-4 ID:SGTC_1773|Compound:st048542|FD-Score:6.10|P-value:5.14E-9 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.08|P-value:6.52E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.42|P-value:8.60E-10 ID:SGTC_1925|Compound:st057770|FD-Score:7.49|P-value:1.02E-12 ID:SGTC_2009|Compound:4012297|FD-Score:3.70|P-value:2.64E-4 ID:SGTC_2141|Compound:5621638|FD-Score:3.37|P-value:8.07E-4 ID:SGTC_2174|Compound:5790901|FD-Score:5.19|P-value:5.66E-7 ID:SGTC_2178|Compound:5812956|FD-Score:3.62|P-value:3.46E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-12.50|P-value:1.55E-32 ID:SGTC_2253|Compound:7938677|FD-Score:-3.65|P-value:2.79E-4 ID:SGTC_2255|Compound:7941087|FD-Score:7.42|P-value:1.62E-12 ID:SGTC_2321|Compound:7390090|FD-Score:3.94|P-value:1.14E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.43|P-value:1.72E-7 ID:SGTC_2339|Compound:9000433|FD-Score:-3.43|P-value:5.78E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.19|P-value:4.34E-5 ID:SGTC_2452|Compound:5863136|FD-Score:4.88|P-value:2.37E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:5.67|P-value:5.33E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.51|P-value:1.16E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:4.52|P-value:1.15E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.46|P-value:6.05E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.30|P-value:2.84E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.54|P-value:4.54E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.74|P-value:2.33E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.18|P-value:4.48E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.41|P-value:7.02E-4 ID:SGTC_2854|Compound:9024559|FD-Score:4.28|P-value:2.99E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.77|P-value:1.79E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.34|P-value:8.98E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.31|P-value:9.89E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.03|P-value:8.06E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.93|P-value:9.97E-5 ID:SGTC_3181|Compound:9108277|FD-Score:4.00|P-value:8.83E-5 ID:SGTC_3265|Compound:9137266|FD-Score:3.71|P-value:2.58E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.07|P-value:4.89E-9 ID:SGTC_3347|Compound:9188721|FD-Score:-3.43|P-value:5.82E-4

Top fitness defect scores for YKL041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_748 0136-0228 9.09 77.9 µM 7.04E-18 redox potentiating 12 5.13E-20
2 SGTC_1925 st057770 7.49 10.1 µM 1.02E-12 TSC3-RPN4 2 3.47E-14
3 SGTC_2255 7941087 7.42 197.4 µM 1.62E-12 5 5.83E-14
4 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 6.60 54.9 µM 2.85E-10 redox potentiating 27 2.00E-11
5 SGTC_1136 pergolide 6.60 1.1 µM 2.99E-10 6 2.11E-11
6 SGTC_1844 rapamycin 6.42 4.0 nM 8.60E-10 83 6.95E-11
7 SGTC_1773 st048542 6.10 73.6 µM 5.14E-9 15 5.22E-10
8 SGTC_159 3970-0959 5.89 50.0 µM 1.61E-8 27 1.90E-9
9 SGTC_2575 plumbagin 5.67 510.0 nM 5.33E-8 superoxide 17 7.32E-9
10 SGTC_2582 agaric acid 5.51 100.0 µM 1.16E-7 redox potentiating 187 1.75E-8
11 SGTC_2322 7413319 5.43 38.2 µM 1.72E-7 ERAD & cell cycle 76 2.75E-8
12 SGTC_1124 fisetin 5.29 1.2 µM 3.50E-7 10 6.12E-8
13 SGTC_149 3970-0822 5.23 46.1 µM 4.61E-7 tubulin folding & SWR complex 44 8.34E-8
14 SGTC_2174 5790901 5.19 200.0 µM 5.66E-7 tubulin folding & SWR complex 20 1.05E-7
15 SGTC_1687 st020778 5.13 55.4 µM 7.35E-7 126 1.41E-7
16 SGTC_1658 st012944 5.08 20.0 µM 9.38E-7 iron homeostasis 45 1.86E-7
17 SGTC_977 1348-1378 5.00 135.0 µM 1.35E-6 11 2.79E-7
18 SGTC_2452 5863136 4.88 48.4 µM 2.37E-6 11 5.29E-7
19 SGTC_21 0849-0113 4.86 23.0 µM 2.54E-6 13 5.73E-7
20 SGTC_497 capsazepine 4.78 133.0 µM 3.70E-6 3 8.74E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.357 1.09E-101 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.339 9.67E-91 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.318 2.13E-79 YKL002W DID4 hom Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
0.285 1.35E-63 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.277 4.50E-60 YPL084W BRO1 hom Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
0.271 2.04E-57 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.245 4.23E-47 YDR486C VPS60 hom Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
0.239 5.98E-45 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.238 1.34E-44 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.224 1.73E-39 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.221 1.62E-38 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.218 2.43E-37 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.214 7.31E-36 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.211 3.16E-35 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.211 3.72E-35 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus