YKL042W / SPC42

Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL042W / SPC42

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:7.33|P-value:1.03E-10 ID:SGTC_106|Compound:0092-0003|FD-Score:5.10|P-value:4.76E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.68|P-value:2.51E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:5.17|P-value:3.66E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:5.87|P-value:1.75E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.08|P-value:2.08E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-4.95|P-value:9.05E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.62|P-value:8.70E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.82|P-value:4.53E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.61|P-value:8.72E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.72|P-value:6.19E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.15|P-value:2.95E-10 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.57|P-value:9.60E-4 ID:SGTC_470|Compound:aa-861|FD-Score:4.79|P-value:1.63E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:6.31|P-value:2.23E-8 ID:SGTC_501|Compound:nsc-95397|FD-Score:-6.15|P-value:5.07E-8 ID:SGTC_592|Compound:k241-0073|FD-Score:4.40|P-value:6.80E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:4.03|P-value:2.33E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:4.72|P-value:2.06E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.83|P-value:2.15E-7 ID:SGTC_833|Compound:3852-0053|FD-Score:5.41|P-value:1.35E-6 ID:SGTC_860|Compound:0443-0016|FD-Score:5.54|P-value:7.69E-7 ID:SGTC_904|Compound:1141-0088|FD-Score:3.75|P-value:5.58E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.95|P-value:3.03E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:4.09|P-value:1.90E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:5.77|P-value:2.74E-7 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.98|P-value:2.78E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.66|P-value:7.41E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.17|P-value:3.78E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.55|P-value:3.96E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.43|P-value:6.11E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.46|P-value:5.42E-5 ID:SGTC_1655|Compound:st012546|FD-Score:3.77|P-value:5.29E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.84|P-value:4.25E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:6.51|P-value:8.04E-9 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.36|P-value:1.68E-6 ID:SGTC_2098|Compound:5376439|FD-Score:4.21|P-value:1.28E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.62|P-value:8.49E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.17|P-value:1.46E-4 ID:SGTC_2323|Compound:6148992|FD-Score:15.70|P-value:2.69E-42 ID:SGTC_2324|Compound:6149169|FD-Score:4.10|P-value:1.83E-4 ID:SGTC_2328|Compound:6201408|FD-Score:5.31|P-value:2.03E-6 ID:SGTC_2511|Compound:berberine|FD-Score:3.57|P-value:9.57E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:6.22|P-value:3.36E-8 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.60|P-value:3.32E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.85|P-value:1.31E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.86|P-value:1.22E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.92|P-value:3.33E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-4.33|P-value:8.83E-5 ID:SGTC_2692|Compound:st077426|FD-Score:-5.06|P-value:5.80E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.68|P-value:6.92E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.73|P-value:2.06E-5 ID:SGTC_2959|Compound:9079155|FD-Score:4.55|P-value:3.96E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.60|P-value:9.24E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.13|P-value:1.74E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-13.00|P-value:8.23E-30 ID:SGTC_3141|Compound:9094609|FD-Score:5.02|P-value:6.50E-6 ID:SGTC_3143|Compound:9086658|FD-Score:4.41|P-value:6.53E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-4.34|P-value:8.64E-5 ID:SGTC_3147|Compound:9097027|FD-Score:5.88|P-value:1.70E-7 ID:SGTC_3151|Compound:9099821|FD-Score:7.09|P-value:3.92E-10 ID:SGTC_3158|Compound:9100007|FD-Score:-3.81|P-value:4.91E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.82|P-value:4.56E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-3.58|P-value:9.77E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.80|P-value:1.54E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:7.33|P-value:1.03E-10 ID:SGTC_106|Compound:0092-0003|FD-Score:5.10|P-value:4.76E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.68|P-value:2.51E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:5.17|P-value:3.66E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:5.87|P-value:1.75E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.08|P-value:2.08E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-4.95|P-value:9.05E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.62|P-value:8.70E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.82|P-value:4.53E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.61|P-value:8.72E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.72|P-value:6.19E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.15|P-value:2.95E-10 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.57|P-value:9.60E-4 ID:SGTC_470|Compound:aa-861|FD-Score:4.79|P-value:1.63E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:6.31|P-value:2.23E-8 ID:SGTC_501|Compound:nsc-95397|FD-Score:-6.15|P-value:5.07E-8 ID:SGTC_592|Compound:k241-0073|FD-Score:4.40|P-value:6.80E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:4.03|P-value:2.33E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:4.72|P-value:2.06E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.83|P-value:2.15E-7 ID:SGTC_833|Compound:3852-0053|FD-Score:5.41|P-value:1.35E-6 ID:SGTC_860|Compound:0443-0016|FD-Score:5.54|P-value:7.69E-7 ID:SGTC_904|Compound:1141-0088|FD-Score:3.75|P-value:5.58E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.95|P-value:3.03E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:4.09|P-value:1.90E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:5.77|P-value:2.74E-7 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.98|P-value:2.78E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.66|P-value:7.41E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.17|P-value:3.78E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.55|P-value:3.96E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.43|P-value:6.11E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.46|P-value:5.42E-5 ID:SGTC_1655|Compound:st012546|FD-Score:3.77|P-value:5.29E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.84|P-value:4.25E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:6.51|P-value:8.04E-9 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.36|P-value:1.68E-6 ID:SGTC_2098|Compound:5376439|FD-Score:4.21|P-value:1.28E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.62|P-value:8.49E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.17|P-value:1.46E-4 ID:SGTC_2323|Compound:6148992|FD-Score:15.70|P-value:2.69E-42 ID:SGTC_2324|Compound:6149169|FD-Score:4.10|P-value:1.83E-4 ID:SGTC_2328|Compound:6201408|FD-Score:5.31|P-value:2.03E-6 ID:SGTC_2511|Compound:berberine|FD-Score:3.57|P-value:9.57E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:6.22|P-value:3.36E-8 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.60|P-value:3.32E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.85|P-value:1.31E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.86|P-value:1.22E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.92|P-value:3.33E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-4.33|P-value:8.83E-5 ID:SGTC_2692|Compound:st077426|FD-Score:-5.06|P-value:5.80E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.68|P-value:6.92E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.73|P-value:2.06E-5 ID:SGTC_2959|Compound:9079155|FD-Score:4.55|P-value:3.96E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.60|P-value:9.24E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.13|P-value:1.74E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-13.00|P-value:8.23E-30 ID:SGTC_3141|Compound:9094609|FD-Score:5.02|P-value:6.50E-6 ID:SGTC_3143|Compound:9086658|FD-Score:4.41|P-value:6.53E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-4.34|P-value:8.64E-5 ID:SGTC_3147|Compound:9097027|FD-Score:5.88|P-value:1.70E-7 ID:SGTC_3151|Compound:9099821|FD-Score:7.09|P-value:3.92E-10 ID:SGTC_3158|Compound:9100007|FD-Score:-3.81|P-value:4.91E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.82|P-value:4.56E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-3.58|P-value:9.77E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.80|P-value:1.54E-5

Top fitness defect scores for YKL042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2323 6148992 15.70 148.3 µM 2.69E-42 1 1.51E-55 8.35
2 SGTC_9 0092-0002 7.33 10.4 µM 1.03E-10 1 1.18E-13 2.28
3 SGTC_3151 9099821 7.09 49.5 µM 3.92E-10 1 6.89E-13 2.81
4 SGTC_1880 MG-132 6.51 525.0 µM 8.04E-9 8 3.72E-11 0.41
5 SGTC_471 1-acyl-paf 6.31 4.0 µM 2.23E-8 DNA intercalators 7 1.43E-10 0.21
6 SGTC_2516 gossypol 6.22 71.5 µM 3.36E-8 3 2.46E-10 0.57
7 SGTC_3147 9097027 5.88 49.5 µM 1.70E-7 2 2.08E-9 1.15
8 SGTC_131 0141-0277 5.87 33.9 µM 1.75E-7 3 2.16E-9 0.33
9 SGTC_1041 0206-0046 5.77 107.0 µM 2.74E-7 3 3.92E-9 1.17
10 SGTC_860 0443-0016 5.54 25.1 µM 7.69E-7 2 1.52E-8 0.89
11 SGTC_833 3852-0053 5.41 558.0 µM 1.35E-6 2 3.21E-8 0.59
12 SGTC_1926 methyl fluorone black 5.36 53.6 µM 1.68E-6 DNA intercalators 13 4.26E-8 0.19
13 SGTC_2328 6201408 5.31 200.0 µM 2.03E-6 5 5.49E-8 0.31
14 SGTC_126 0417-1624 5.17 672.5 µM 3.66E-6 DNA intercalators 8 1.19E-7 0.59
15 SGTC_106 0092-0003 5.10 11.6 µM 4.76E-6 copper-dependent oxidative stress 4 1.68E-7 0.12
16 SGTC_3141 9094609 5.02 49.5 µM 6.50E-6 iron homeostasis 8 2.53E-7 0.02
17 SGTC_2563 tomatine 4.86 8.5 µM 1.22E-5 8 5.79E-7 0.13
18 SGTC_3283 9109332 4.80 35.8 µM 1.54E-5 DNA intercalators 2 7.86E-7 0.64
19 SGTC_470 aa-861 4.79 153.0 µM 1.63E-5 sphingolipid biosynthesis & PDR1 10 8.44E-7 0.24
20 SGTC_680 0417-1641 4.72 114.0 µM 2.06E-5 RPP1 & pyrimidine depletion 4 1.15E-6 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.95E-24 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.152 9.95E-19 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.145 3.37E-17 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.145 3.54E-17 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.144 6.60E-17 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.143 1.11E-16 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.139 7.15E-16 YML093W UTP14 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.135 4.78E-15 YMR288W HSH155 het U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
0.132 1.67E-14 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.131 3.24E-14 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.128 1.18E-13 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.119 5.39E-12 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.118 8.33E-12 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.117 1.24E-11 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.116 1.67E-11 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation