YKL047W_p / ANR2

Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL047W / ANR2

Click on Significant Values for Screen Details ID:SGTC_271|Compound:rotenone|FD-Score:3.40|P-value:3.50E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-3.74|P-value:9.65E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:4.79|P-value:8.69E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.19|P-value:7.35E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.37|P-value:3.79E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.50|P-value:2.39E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:7.61|P-value:1.58E-14 ID:SGTC_406|Compound:estrone|FD-Score:3.13|P-value:8.79E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.72|P-value:1.05E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.77|P-value:8.35E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:3.23|P-value:6.41E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.56|P-value:1.91E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.24|P-value:6.25E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.11|P-value:9.89E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.18|P-value:7.43E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:5.44|P-value:2.80E-8 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.10|P-value:2.10E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.60|P-value:1.69E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.77|P-value:9.79E-7 ID:SGTC_1699|Compound:st031318|FD-Score:-3.50|P-value:2.47E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-4.32|P-value:8.45E-6 ID:SGTC_1868|Compound:st057644|FD-Score:5.13|P-value:1.56E-7 ID:SGTC_1921|Compound:5740136|FD-Score:3.79|P-value:7.89E-5 ID:SGTC_1923|Compound:st058458|FD-Score:5.22|P-value:9.32E-8 ID:SGTC_1934|Compound:st074720|FD-Score:3.70|P-value:1.12E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.39|P-value:3.62E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.54|P-value:2.03E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.72|P-value:1.06E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.13|P-value:8.79E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.89|P-value:5.28E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.36|P-value:4.02E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.78|P-value:8.11E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.89|P-value:5.24E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.30|P-value:4.89E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-5.48|P-value:2.33E-8 ID:SGTC_2676|Compound:harmalol|FD-Score:3.53|P-value:2.14E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-4.36|P-value:6.94E-6 ID:SGTC_2837|Compound:9008476|FD-Score:6.17|P-value:3.73E-10 ID:SGTC_2991|Compound:9074669|FD-Score:4.19|P-value:1.46E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.15|P-value:1.69E-5 ID:SGTC_3009|Compound:9080819|FD-Score:4.16|P-value:1.65E-5 ID:SGTC_3137|Compound:9097352|FD-Score:5.35|P-value:4.70E-8 ID:SGTC_3205|Compound:9113483|FD-Score:3.24|P-value:6.19E-4 ID:SGTC_3259|Compound:9138485|FD-Score:5.35|P-value:4.72E-8 ID:SGTC_3272|Compound:9137413|FD-Score:3.33|P-value:4.44E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.85|P-value:6.04E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.38|P-value:3.73E-4 ID:SGTC_3345|Compound:9148410|FD-Score:4.92|P-value:4.47E-7 ID:SGTC_3354|Compound:9151612|FD-Score:3.51|P-value:2.31E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.40|P-value:3.50E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-3.74|P-value:9.65E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:4.79|P-value:8.69E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.19|P-value:7.35E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.37|P-value:3.79E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.50|P-value:2.39E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:7.61|P-value:1.58E-14 ID:SGTC_406|Compound:estrone|FD-Score:3.13|P-value:8.79E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.72|P-value:1.05E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.77|P-value:8.35E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:3.23|P-value:6.41E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.56|P-value:1.91E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.24|P-value:6.25E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.11|P-value:9.89E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.18|P-value:7.43E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:5.44|P-value:2.80E-8 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.10|P-value:2.10E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.60|P-value:1.69E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.77|P-value:9.79E-7 ID:SGTC_1699|Compound:st031318|FD-Score:-3.50|P-value:2.47E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-4.32|P-value:8.45E-6 ID:SGTC_1868|Compound:st057644|FD-Score:5.13|P-value:1.56E-7 ID:SGTC_1921|Compound:5740136|FD-Score:3.79|P-value:7.89E-5 ID:SGTC_1923|Compound:st058458|FD-Score:5.22|P-value:9.32E-8 ID:SGTC_1934|Compound:st074720|FD-Score:3.70|P-value:1.12E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.39|P-value:3.62E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.54|P-value:2.03E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.72|P-value:1.06E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.13|P-value:8.79E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.89|P-value:5.28E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.36|P-value:4.02E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.78|P-value:8.11E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.89|P-value:5.24E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.30|P-value:4.89E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-5.48|P-value:2.33E-8 ID:SGTC_2676|Compound:harmalol|FD-Score:3.53|P-value:2.14E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-4.36|P-value:6.94E-6 ID:SGTC_2837|Compound:9008476|FD-Score:6.17|P-value:3.73E-10 ID:SGTC_2991|Compound:9074669|FD-Score:4.19|P-value:1.46E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.15|P-value:1.69E-5 ID:SGTC_3009|Compound:9080819|FD-Score:4.16|P-value:1.65E-5 ID:SGTC_3137|Compound:9097352|FD-Score:5.35|P-value:4.70E-8 ID:SGTC_3205|Compound:9113483|FD-Score:3.24|P-value:6.19E-4 ID:SGTC_3259|Compound:9138485|FD-Score:5.35|P-value:4.72E-8 ID:SGTC_3272|Compound:9137413|FD-Score:3.33|P-value:4.44E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.85|P-value:6.04E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.38|P-value:3.73E-4 ID:SGTC_3345|Compound:9148410|FD-Score:4.92|P-value:4.47E-7 ID:SGTC_3354|Compound:9151612|FD-Score:3.51|P-value:2.31E-4

Top fitness defect scores for YKL047W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_387 norethindrone acetate 7.61 66.7 µM 1.58E-14 2 1.37E-14
2 SGTC_2837 9008476 6.17 45.5 µM 3.73E-10 4 3.41E-10
3 SGTC_920 mycophenolic acid 5.44 780.4 nM 2.80E-8 4 2.61E-8
4 SGTC_3137 9097352 5.35 49.5 µM 4.70E-8 14 4.41E-8
5 SGTC_3259 9138485 5.35 49.5 µM 4.72E-8 3 4.43E-8
6 SGTC_1923 st058458 5.22 19.1 µM 9.32E-8 12 8.77E-8
7 SGTC_1868 st057644 5.13 42.7 µM 1.56E-7 16 1.47E-7
8 SGTC_3345 9148410 4.92 3.6 µM 4.47E-7 2 4.24E-7
9 SGTC_286 k060-0067 4.79 22.9 µM 8.69E-7 tubulin folding & SWR complex 14 8.26E-7
10 SGTC_1672 st016598 4.77 6.5 µM 9.79E-7 endomembrane recycling 45 9.31E-7
11 SGTC_2991 9074669 4.19 71.4 µM 1.46E-5 azole & statin 50 1.41E-5
12 SGTC_3009 9080819 4.16 71.4 µM 1.65E-5 13 1.59E-5
13 SGTC_3002 9075603 4.15 71.4 µM 1.69E-5 18 1.63E-5
14 SGTC_1264 0783-0040 4.10 158.0 µM 2.10E-5 22 2.03E-5
15 SGTC_2472 5377652 3.89 49.4 µM 5.24E-5 TRP & mitochondrial translation 59 5.09E-5
16 SGTC_2125 5246583 3.89 200.0 µM 5.28E-5 tubulin folding & SWR complex 44 5.12E-5
17 SGTC_3305 9127027 3.85 53.8 µM 6.04E-5 19 5.86E-5
18 SGTC_1921 5740136 3.79 50.0 µM 7.89E-5 TRP & mitochondrial translation 66 7.67E-5
19 SGTC_2342 7990637 3.78 118.9 µM 8.11E-5 RNA processing & uracil transport 42 7.88E-5
20 SGTC_415 dibenzyl ketone 3.77 100.0 µM 8.35E-5 13 8.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.12E-8 YNL090W RHO2 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.098 1.35E-8 YBR217W ATG12 hom Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.090 1.70E-7 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.085 7.47E-7 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.085 8.69E-7 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.084 1.15E-6 YLR043C TRX1 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.079 4.72E-6 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.079 4.68E-6 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.077 7.24E-6 YDR160W SSY1 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.076 1.01E-5 YKR052C MRS4 hom Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication
0.075 1.29E-5 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.075 1.35E-5 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.075 1.36E-5 YDL237W AIM6 hom Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
0.075 1.42E-5 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.075 1.49E-5 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum