YKL048C / ELM1

Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL048C / ELM1

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:4.24|P-value:8.80E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:10.30|P-value:4.90E-26 ID:SGTC_83|Compound:0170-0301|FD-Score:3.63|P-value:1.21E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.94|P-value:8.52E-10 ID:SGTC_138|Compound:0850-0259|FD-Score:7.97|P-value:2.82E-16 ID:SGTC_146|Compound:3448-8650|FD-Score:3.46|P-value:2.36E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.25|P-value:4.15E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:4.23|P-value:9.45E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:11.80|P-value:1.27E-33 ID:SGTC_160|Compound:3453-0671|FD-Score:10.00|P-value:9.15E-25 ID:SGTC_174|Compound:3553-0389|FD-Score:3.41|P-value:2.88E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.12|P-value:8.26E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.55|P-value:1.70E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.02|P-value:9.26E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.98|P-value:2.82E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.11|P-value:8.48E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:5.27|P-value:4.72E-8 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.06|P-value:8.18E-4 ID:SGTC_401|Compound:neomycin|FD-Score:4.24|P-value:8.75E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:3.38|P-value:3.17E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.24|P-value:4.26E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.14|P-value:6.02E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-4.25|P-value:6.24E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:4.82|P-value:5.15E-7 ID:SGTC_544|Compound:k015-0020|FD-Score:3.22|P-value:5.75E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.44|P-value:2.56E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.96|P-value:2.51E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:4.94|P-value:2.87E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:4.27|P-value:7.85E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:4.73|P-value:8.43E-7 ID:SGTC_701|Compound:4424-0219|FD-Score:6.01|P-value:5.50E-10 ID:SGTC_705|Compound:1124-0212|FD-Score:4.07|P-value:1.92E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.99|P-value:2.69E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:4.90|P-value:3.45E-7 ID:SGTC_895|Compound:0964-0006|FD-Score:4.03|P-value:2.27E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.06|P-value:2.02E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:8.83|P-value:1.50E-19 ID:SGTC_998|Compound:3996-0085|FD-Score:6.48|P-value:2.45E-11 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.75|P-value:7.52E-7 ID:SGTC_1064|Compound:honokiol|FD-Score:4.93|P-value:2.99E-7 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.23|P-value:5.53E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.76|P-value:7.30E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:5.21|P-value:6.44E-8 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.26|P-value:8.33E-6 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.21|P-value:5.99E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.43|P-value:2.68E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.96|P-value:2.50E-7 ID:SGTC_1312|Compound:1218-2183|FD-Score:-4.42|P-value:2.80E-6 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.78|P-value:6.53E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.90|P-value:4.05E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.12|P-value:8.12E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.16|P-value:7.23E-4 ID:SGTC_1624|Compound:st003710|FD-Score:4.22|P-value:9.97E-6 ID:SGTC_1627|Compound:st003713|FD-Score:3.46|P-value:2.39E-4 ID:SGTC_1666|Compound:st014829|FD-Score:5.68|P-value:4.17E-9 ID:SGTC_1690|Compound:st023502|FD-Score:3.43|P-value:2.68E-4 ID:SGTC_1699|Compound:st031318|FD-Score:4.33|P-value:5.84E-6 ID:SGTC_1707|Compound:st032323|FD-Score:7.17|P-value:1.75E-13 ID:SGTC_1812|Compound:st052057|FD-Score:3.36|P-value:3.53E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.73|P-value:8.05E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.32|P-value:4.02E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.57|P-value:1.18E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.37|P-value:4.79E-6 ID:SGTC_2106|Compound:5357045|FD-Score:3.78|P-value:6.62E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.08|P-value:9.54E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.57|P-value:1.18E-4 ID:SGTC_2184|Compound:6075246|FD-Score:5.20|P-value:7.00E-8 ID:SGTC_2280|Compound:7785178|FD-Score:-4.12|P-value:1.13E-5 ID:SGTC_2286|Compound:7945697|FD-Score:6.52|P-value:1.82E-11 ID:SGTC_2289|Compound:7946404|FD-Score:4.75|P-value:7.52E-7 ID:SGTC_2413|Compound:inermin|FD-Score:4.48|P-value:2.85E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.80|P-value:3.22E-33 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.48|P-value:2.24E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.44|P-value:2.59E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.09|P-value:9.19E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.29|P-value:6.96E-14 ID:SGTC_3003|Compound:9075612|FD-Score:5.27|P-value:4.71E-8 ID:SGTC_3111|Compound:9122088|FD-Score:4.57|P-value:1.86E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.81|P-value:5.97E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.16|P-value:7.18E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.75|P-value:7.65E-5 ID:SGTC_3257|Compound:9139206|FD-Score:4.52|P-value:2.39E-6 ID:SGTC_3285|Compound:9112818|FD-Score:4.60|P-value:1.57E-6 ID:SGTC_3304|Compound:9125678|FD-Score:3.39|P-value:3.09E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.16|P-value:7.18E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:4.24|P-value:8.80E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:10.30|P-value:4.90E-26 ID:SGTC_83|Compound:0170-0301|FD-Score:3.63|P-value:1.21E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.94|P-value:8.52E-10 ID:SGTC_138|Compound:0850-0259|FD-Score:7.97|P-value:2.82E-16 ID:SGTC_146|Compound:3448-8650|FD-Score:3.46|P-value:2.36E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.25|P-value:4.15E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:4.23|P-value:9.45E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:11.80|P-value:1.27E-33 ID:SGTC_160|Compound:3453-0671|FD-Score:10.00|P-value:9.15E-25 ID:SGTC_174|Compound:3553-0389|FD-Score:3.41|P-value:2.88E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.12|P-value:8.26E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.55|P-value:1.70E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.02|P-value:9.26E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.98|P-value:2.82E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.11|P-value:8.48E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:5.27|P-value:4.72E-8 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.06|P-value:8.18E-4 ID:SGTC_401|Compound:neomycin|FD-Score:4.24|P-value:8.75E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:3.38|P-value:3.17E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.24|P-value:4.26E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.14|P-value:6.02E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-4.25|P-value:6.24E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:4.82|P-value:5.15E-7 ID:SGTC_544|Compound:k015-0020|FD-Score:3.22|P-value:5.75E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.44|P-value:2.56E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.96|P-value:2.51E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:4.94|P-value:2.87E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:4.27|P-value:7.85E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:4.73|P-value:8.43E-7 ID:SGTC_701|Compound:4424-0219|FD-Score:6.01|P-value:5.50E-10 ID:SGTC_705|Compound:1124-0212|FD-Score:4.07|P-value:1.92E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.99|P-value:2.69E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:4.90|P-value:3.45E-7 ID:SGTC_895|Compound:0964-0006|FD-Score:4.03|P-value:2.27E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.06|P-value:2.02E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:8.83|P-value:1.50E-19 ID:SGTC_998|Compound:3996-0085|FD-Score:6.48|P-value:2.45E-11 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.75|P-value:7.52E-7 ID:SGTC_1064|Compound:honokiol|FD-Score:4.93|P-value:2.99E-7 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.23|P-value:5.53E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.76|P-value:7.30E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:5.21|P-value:6.44E-8 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.26|P-value:8.33E-6 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.21|P-value:5.99E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.43|P-value:2.68E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.96|P-value:2.50E-7 ID:SGTC_1312|Compound:1218-2183|FD-Score:-4.42|P-value:2.80E-6 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.78|P-value:6.53E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.90|P-value:4.05E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.12|P-value:8.12E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.16|P-value:7.23E-4 ID:SGTC_1624|Compound:st003710|FD-Score:4.22|P-value:9.97E-6 ID:SGTC_1627|Compound:st003713|FD-Score:3.46|P-value:2.39E-4 ID:SGTC_1666|Compound:st014829|FD-Score:5.68|P-value:4.17E-9 ID:SGTC_1690|Compound:st023502|FD-Score:3.43|P-value:2.68E-4 ID:SGTC_1699|Compound:st031318|FD-Score:4.33|P-value:5.84E-6 ID:SGTC_1707|Compound:st032323|FD-Score:7.17|P-value:1.75E-13 ID:SGTC_1812|Compound:st052057|FD-Score:3.36|P-value:3.53E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.73|P-value:8.05E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.32|P-value:4.02E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.57|P-value:1.18E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.37|P-value:4.79E-6 ID:SGTC_2106|Compound:5357045|FD-Score:3.78|P-value:6.62E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.08|P-value:9.54E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.57|P-value:1.18E-4 ID:SGTC_2184|Compound:6075246|FD-Score:5.20|P-value:7.00E-8 ID:SGTC_2280|Compound:7785178|FD-Score:-4.12|P-value:1.13E-5 ID:SGTC_2286|Compound:7945697|FD-Score:6.52|P-value:1.82E-11 ID:SGTC_2289|Compound:7946404|FD-Score:4.75|P-value:7.52E-7 ID:SGTC_2413|Compound:inermin|FD-Score:4.48|P-value:2.85E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.80|P-value:3.22E-33 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.48|P-value:2.24E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.44|P-value:2.59E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.09|P-value:9.19E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.29|P-value:6.96E-14 ID:SGTC_3003|Compound:9075612|FD-Score:5.27|P-value:4.71E-8 ID:SGTC_3111|Compound:9122088|FD-Score:4.57|P-value:1.86E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.81|P-value:5.97E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.16|P-value:7.18E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.75|P-value:7.65E-5 ID:SGTC_3257|Compound:9139206|FD-Score:4.52|P-value:2.39E-6 ID:SGTC_3285|Compound:9112818|FD-Score:4.60|P-value:1.57E-6 ID:SGTC_3304|Compound:9125678|FD-Score:3.39|P-value:3.09E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.16|P-value:7.18E-4

Top fitness defect scores for YKL048C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_157 1348-1695 11.80 65.8 µM 1.27E-33 iron homeostasis 9 1.39E-32
2 SGTC_2582 agaric acid 11.80 100.0 µM 3.22E-33 redox potentiating 41 3.40E-32
3 SGTC_58 0957-0393 10.30 9.0 µM 4.90E-26 cell wall 73 2.90E-25
4 SGTC_160 3453-0671 10.00 289.7 µM 9.15E-25 2 4.89E-24
5 SGTC_972 1319-0219 8.83 195.0 µM 1.50E-19 2 5.29E-19
6 SGTC_138 0850-0259 7.97 40.9 µM 2.82E-16 cell wall 62 7.70E-16
7 SGTC_2912 7964298 7.29 10.9 µM 6.96E-14 cell wall 30 1.58E-13
8 SGTC_1707 st032323 7.17 6.3 µM 1.75E-13 DNA damage response 15 3.85E-13
9 SGTC_2286 7945697 6.52 125.0 µM 1.82E-11 12 3.44E-11
10 SGTC_998 3996-0085 6.48 177.0 µM 2.45E-11 3 4.59E-11
11 SGTC_701 4424-0219 6.01 185.0 µM 5.50E-10 calcium & mitochondrial duress 4 9.29E-10
12 SGTC_117 lucigenin 5.94 22.1 µM 8.52E-10 redox potentiating 39 1.42E-9
13 SGTC_1666 st014829 5.68 29.0 µM 4.17E-9 calcium & mitochondrial duress 10 6.61E-9
14 SGTC_3003 9075612 5.27 71.4 µM 4.71E-8 6 6.91E-8
15 SGTC_360 0957-0399 5.27 1.0 µM 4.72E-8 cell wall 19 6.93E-8
16 SGTC_1227 3909-8010 5.21 46.6 µM 6.44E-8 4 9.36E-8
17 SGTC_2184 6075246 5.20 200.0 µM 7.00E-8 9 1.01E-7
18 SGTC_1309 pyrazolanthrone 4.96 13.4 µM 2.50E-7 12 3.49E-7
19 SGTC_567 1080-0542 4.96 68.4 µM 2.51E-7 2 3.50E-7
20 SGTC_576 1073-0113 4.94 22.7 µM 2.87E-7 redox potentiating 36 3.98E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.286 5.39E-64 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.282 1.54E-62 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.268 2.59E-56 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.254 1.18E-50 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.234 4.85E-43 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.222 8.45E-39 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.215 2.37E-36 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.204 6.12E-33 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.203 1.20E-32 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.203 1.88E-32 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.202 3.86E-32 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.197 1.51E-30 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.197 1.58E-30 YNL271C BNI1 hom Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
0.196 2.55E-30 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.196 2.92E-30 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication