HIPHOP chemogenomics database
YKL053C-A / MDM35 
Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKL053C-A deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.172 | 9.85E-24 | YKR028W | SAP190 | hom | Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication |
| 0.101 | 5.34E-9 | YER023W | PRO3 | het | Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis |
| 0.098 | 1.15E-8 | YIR032C | DAL3 | hom | Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression |
| 0.088 | 3.05E-7 | YDR285W | ZIP1 | hom | Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate |
| 0.087 | 4.76E-7 | YJL142C_d | IRC9_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.083 | 1.81E-6 | YCR007C_p | YCR007C_p | hom | Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene |
| 0.081 | 2.78E-6 | YHR210C_p | YHR210C_p | hom | Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions |
| 0.080 | 3.43E-6 | YJR023C_d | YJR023C_d | het | Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing |
| 0.080 | 3.63E-6 | YPL099C | AIM43 | hom | Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss |
| 0.075 | 1.37E-5 | YER116C | SLX8 | hom | Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress |
| 0.075 | 1.50E-5 | YBL058W | SHP1 | hom | UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate |
| 0.073 | 2.08E-5 | YHR156C | LIN1 | hom | Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication |
| 0.071 | 3.76E-5 | YMR011W | HXT2 | hom | High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose |
| 0.071 | 3.86E-5 | YNL095C_p | YNL095C_p | hom | Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication |
| 0.071 | 4.10E-5 | YMR023C | MSS1 | hom | Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 |