YKL055C / OAR1

Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL055C / OAR1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.80|P-value:3.25E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.88|P-value:2.47E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:9.00|P-value:3.24E-16 ID:SGTC_59|Compound:0330-0160|FD-Score:3.84|P-value:2.84E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.48|P-value:8.96E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.68|P-value:4.78E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.08|P-value:1.26E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.81|P-value:8.13E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:8.26|P-value:6.14E-14 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.14|P-value:1.80E-8 ID:SGTC_279|Compound:1273-0055|FD-Score:3.64|P-value:5.50E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.72|P-value:4.26E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.27|P-value:6.38E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.69|P-value:4.72E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:7.77|P-value:1.60E-12 ID:SGTC_413|Compound:propylparaben|FD-Score:3.85|P-value:2.75E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.91|P-value:2.30E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.16|P-value:1.87E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.48|P-value:9.12E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.72|P-value:4.17E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.78|P-value:8.98E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:4.52|P-value:2.46E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:4.10|P-value:1.20E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.67|P-value:1.40E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.94|P-value:4.97E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.06|P-value:1.34E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.80|P-value:3.23E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.30|P-value:5.70E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.76|P-value:3.75E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.40|P-value:6.28E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.70|P-value:4.52E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.68|P-value:4.80E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.02|P-value:1.55E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.13|P-value:1.06E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.43|P-value:3.50E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.89|P-value:5.52E-6 ID:SGTC_1737|Compound:st035557|FD-Score:3.54|P-value:7.49E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.48|P-value:9.07E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.25|P-value:6.81E-5 ID:SGTC_1967|Compound:st070177|FD-Score:4.73|P-value:1.12E-5 ID:SGTC_1970|Compound:st070122|FD-Score:8.93|P-value:5.34E-16 ID:SGTC_1992|Compound:st073643|FD-Score:3.88|P-value:2.51E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.60|P-value:6.13E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.65|P-value:5.21E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.25|P-value:6.76E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.67|P-value:4.99E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.50|P-value:8.39E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-4.62|P-value:1.63E-5 ID:SGTC_2294|Compound:7971431|FD-Score:4.20|P-value:8.11E-5 ID:SGTC_2332|Compound:7982454|FD-Score:4.05|P-value:1.40E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-6.63|P-value:1.33E-9 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.71|P-value:4.32E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.94|P-value:2.06E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.75|P-value:3.70E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.41|P-value:3.80E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.36|P-value:5.66E-9 ID:SGTC_2589|Compound:lobaric acid|FD-Score:8.31|P-value:4.46E-14 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.17|P-value:8.97E-5 ID:SGTC_2591|Compound:skatole|FD-Score:5.53|P-value:3.48E-7 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.27|P-value:6.31E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.64|P-value:5.28E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.61|P-value:5.87E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.48|P-value:9.00E-4 ID:SGTC_2974|Compound:9094440|FD-Score:5.08|P-value:2.54E-6 ID:SGTC_3001|Compound:9076041|FD-Score:4.14|P-value:1.03E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-3.82|P-value:3.01E-4 ID:SGTC_3116|Compound:9124943|FD-Score:6.18|P-value:1.44E-8 ID:SGTC_3118|Compound:9124250|FD-Score:3.50|P-value:8.39E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.94|P-value:2.04E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.56|P-value:6.98E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.92|P-value:2.22E-4 ID:SGTC_3254|Compound:9136651|FD-Score:4.41|P-value:3.84E-5 ID:SGTC_3332|Compound:9141069|FD-Score:3.58|P-value:6.54E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.80|P-value:3.25E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.88|P-value:2.47E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:9.00|P-value:3.24E-16 ID:SGTC_59|Compound:0330-0160|FD-Score:3.84|P-value:2.84E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.48|P-value:8.96E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.68|P-value:4.78E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.08|P-value:1.26E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.81|P-value:8.13E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:8.26|P-value:6.14E-14 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.14|P-value:1.80E-8 ID:SGTC_279|Compound:1273-0055|FD-Score:3.64|P-value:5.50E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.72|P-value:4.26E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.27|P-value:6.38E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.69|P-value:4.72E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:7.77|P-value:1.60E-12 ID:SGTC_413|Compound:propylparaben|FD-Score:3.85|P-value:2.75E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.91|P-value:2.30E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.16|P-value:1.87E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.48|P-value:9.12E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.72|P-value:4.17E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.78|P-value:8.98E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:4.52|P-value:2.46E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:4.10|P-value:1.20E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.67|P-value:1.40E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.94|P-value:4.97E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.06|P-value:1.34E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.80|P-value:3.23E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.30|P-value:5.70E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.76|P-value:3.75E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.40|P-value:6.28E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.70|P-value:4.52E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.68|P-value:4.80E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.02|P-value:1.55E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.13|P-value:1.06E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.43|P-value:3.50E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.89|P-value:5.52E-6 ID:SGTC_1737|Compound:st035557|FD-Score:3.54|P-value:7.49E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.48|P-value:9.07E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.25|P-value:6.81E-5 ID:SGTC_1967|Compound:st070177|FD-Score:4.73|P-value:1.12E-5 ID:SGTC_1970|Compound:st070122|FD-Score:8.93|P-value:5.34E-16 ID:SGTC_1992|Compound:st073643|FD-Score:3.88|P-value:2.51E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.60|P-value:6.13E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.65|P-value:5.21E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.25|P-value:6.76E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.67|P-value:4.99E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.50|P-value:8.39E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-4.62|P-value:1.63E-5 ID:SGTC_2294|Compound:7971431|FD-Score:4.20|P-value:8.11E-5 ID:SGTC_2332|Compound:7982454|FD-Score:4.05|P-value:1.40E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-6.63|P-value:1.33E-9 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.71|P-value:4.32E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.94|P-value:2.06E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.75|P-value:3.70E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.41|P-value:3.80E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.36|P-value:5.66E-9 ID:SGTC_2589|Compound:lobaric acid|FD-Score:8.31|P-value:4.46E-14 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.17|P-value:8.97E-5 ID:SGTC_2591|Compound:skatole|FD-Score:5.53|P-value:3.48E-7 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.27|P-value:6.31E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.64|P-value:5.28E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.61|P-value:5.87E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.48|P-value:9.00E-4 ID:SGTC_2974|Compound:9094440|FD-Score:5.08|P-value:2.54E-6 ID:SGTC_3001|Compound:9076041|FD-Score:4.14|P-value:1.03E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-3.82|P-value:3.01E-4 ID:SGTC_3116|Compound:9124943|FD-Score:6.18|P-value:1.44E-8 ID:SGTC_3118|Compound:9124250|FD-Score:3.50|P-value:8.39E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.94|P-value:2.04E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.56|P-value:6.98E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.92|P-value:2.22E-4 ID:SGTC_3254|Compound:9136651|FD-Score:4.41|P-value:3.84E-5 ID:SGTC_3332|Compound:9141069|FD-Score:3.58|P-value:6.54E-4

Top fitness defect scores for YKL055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_36 0335-0881 9.00 14.2 µM 3.24E-16 ubiquinone biosynthesis & proteasome 25 1.10E-19
2 SGTC_1970 st070122 8.93 35.8 µM 5.34E-16 TSC3-RPN4 2 2.04E-19
3 SGTC_2589 lobaric acid 8.31 100.0 µM 4.46E-14 1 4.86E-17
4 SGTC_236 1509-0011 8.26 5.3 µM 6.14E-14 243 7.21E-17
5 SGTC_386 1509-0011 7.77 3.1 µM 1.60E-12 70 4.08E-15
6 SGTC_3116 9124943 6.18 49.5 µM 1.44E-8 2 3.14E-10
7 SGTC_275 trichlorophene 6.14 5.7 µM 1.80E-8 mitochondrial stress 113 4.14E-10
8 SGTC_1036 k216-0215 5.94 33.5 µM 4.97E-8 mitochondrial response to ROS 14 1.44E-9
9 SGTC_2591 skatole 5.53 100.0 µM 3.48E-7 7 1.60E-8
10 SGTC_1353 1498-1206 5.40 8.1 µM 6.28E-7 mitochondrial response to ROS 24 3.30E-8
11 SGTC_778 3456-2434 5.16 196.0 µM 1.87E-6 mitochondrial response to ROS 40 1.27E-7
12 SGTC_2974 9094440 5.08 9.7 µM 2.54E-6 ergosterol biosynthesis 18 1.85E-7
13 SGTC_227 fluconazole 4.81 33.5 µM 8.13E-6 azole & statin 57 7.73E-7
14 SGTC_852 0418-0143 4.78 439.0 µM 8.98E-6 calcium & mitochondrial duress 44 8.74E-7
15 SGTC_1967 st070177 4.73 51.4 µM 1.12E-5 7 1.15E-6
16 SGTC_969 1313-0238 4.67 134.0 µM 1.40E-5 mitochondrial processes 12 1.51E-6
17 SGTC_902 1120-0002 4.52 2.1 µM 2.46E-5 azole & statin 33 3.02E-6
18 SGTC_1687 st020778 4.43 55.4 µM 3.50E-5 154 4.66E-6
19 SGTC_2557 derrustone 4.41 83.8 µM 3.80E-5 22 5.16E-6
20 SGTC_3254 9136651 4.41 49.5 µM 3.84E-5 DNA damage response 15 5.22E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.314 7.16E-78 YJL046W AIM22 hom Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
0.309 2.93E-75 YFL018C LPD1 hom Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
0.295 3.47E-68 YER061C CEM1 hom Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
0.265 6.04E-55 YHR067W HTD2 hom Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
0.247 1.17E-47 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.243 2.39E-46 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.242 6.57E-46 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.239 5.78E-45 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.239 9.12E-45 YLR239C LIP2 hom Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
0.238 1.35E-44 YGR257C MTM1 hom Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.237 6.37E-44 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.235 1.93E-43 YFL016C MDJ1 hom Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
0.235 3.19E-43 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.234 4.54E-43 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.234 4.63E-43 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein