YKL056C / TMA19

Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL056C / TMA19

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:-3.91|P-value:9.60E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.06|P-value:4.11E-12 ID:SGTC_59|Compound:0330-0160|FD-Score:3.19|P-value:9.42E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.42|P-value:4.37E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.61|P-value:2.20E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.17|P-value:9.92E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:4.99|P-value:6.43E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:3.91|P-value:7.24E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.47|P-value:6.98E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:3.18|P-value:9.77E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.45|P-value:5.05E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.85|P-value:1.23E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.29|P-value:6.77E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.20|P-value:8.99E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.08|P-value:3.58E-12 ID:SGTC_813|Compound:k007-0158|FD-Score:-4.89|P-value:1.49E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:-4.40|P-value:1.34E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.95|P-value:6.07E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.51|P-value:3.22E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.18|P-value:9.57E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.83|P-value:9.91E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.19|P-value:9.43E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.20|P-value:9.07E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.44|P-value:4.07E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.53|P-value:2.99E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.19|P-value:9.27E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.13|P-value:3.00E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.78|P-value:1.20E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.02|P-value:4.58E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.55|P-value:2.75E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:7.73|P-value:3.74E-14 ID:SGTC_1916|Compound:st067606|FD-Score:3.60|P-value:2.32E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.32|P-value:6.13E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.23|P-value:8.22E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.18|P-value:9.66E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.57|P-value:4.51E-6 ID:SGTC_2078|Compound:5212016|FD-Score:5.10|P-value:3.81E-7 ID:SGTC_2297|Compound:7971671|FD-Score:3.50|P-value:3.25E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.51|P-value:4.22E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.32|P-value:6.22E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.79|P-value:1.53E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.22|P-value:8.63E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.49|P-value:3.45E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.50|P-value:3.29E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.97|P-value:1.05E-6 ID:SGTC_2947|Compound:9072639|FD-Score:-3.85|P-value:1.22E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.26|P-value:7.53E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.45|P-value:3.93E-4 ID:SGTC_3114|Compound:9122766|FD-Score:4.72|P-value:2.32E-6 ID:SGTC_3123|Compound:9126162|FD-Score:6.16|P-value:1.19E-9 ID:SGTC_3129|Compound:9127257|FD-Score:-6.17|P-value:1.73E-9 ID:SGTC_3130|Compound:9127414|FD-Score:6.18|P-value:1.05E-9 ID:SGTC_3133|Compound:9127736|FD-Score:6.07|P-value:1.99E-9 ID:SGTC_3282|Compound:9108498|FD-Score:4.93|P-value:8.63E-7 ID:SGTC_57|Compound:miconazole|FD-Score:-3.91|P-value:9.60E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.06|P-value:4.11E-12 ID:SGTC_59|Compound:0330-0160|FD-Score:3.19|P-value:9.42E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.42|P-value:4.37E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.61|P-value:2.20E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.17|P-value:9.92E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:4.99|P-value:6.43E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:3.91|P-value:7.24E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.47|P-value:6.98E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:3.18|P-value:9.77E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.45|P-value:5.05E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.85|P-value:1.23E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.29|P-value:6.77E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.20|P-value:8.99E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.08|P-value:3.58E-12 ID:SGTC_813|Compound:k007-0158|FD-Score:-4.89|P-value:1.49E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:-4.40|P-value:1.34E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.95|P-value:6.07E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.51|P-value:3.22E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.18|P-value:9.57E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.83|P-value:9.91E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.19|P-value:9.43E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.20|P-value:9.07E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.44|P-value:4.07E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.53|P-value:2.99E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.19|P-value:9.27E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.13|P-value:3.00E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.78|P-value:1.20E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.02|P-value:4.58E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.55|P-value:2.75E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:7.73|P-value:3.74E-14 ID:SGTC_1916|Compound:st067606|FD-Score:3.60|P-value:2.32E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.32|P-value:6.13E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.23|P-value:8.22E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.18|P-value:9.66E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.57|P-value:4.51E-6 ID:SGTC_2078|Compound:5212016|FD-Score:5.10|P-value:3.81E-7 ID:SGTC_2297|Compound:7971671|FD-Score:3.50|P-value:3.25E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.51|P-value:4.22E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.32|P-value:6.22E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.79|P-value:1.53E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.22|P-value:8.63E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.49|P-value:3.45E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.50|P-value:3.29E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.97|P-value:1.05E-6 ID:SGTC_2947|Compound:9072639|FD-Score:-3.85|P-value:1.22E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.26|P-value:7.53E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.45|P-value:3.93E-4 ID:SGTC_3114|Compound:9122766|FD-Score:4.72|P-value:2.32E-6 ID:SGTC_3123|Compound:9126162|FD-Score:6.16|P-value:1.19E-9 ID:SGTC_3129|Compound:9127257|FD-Score:-6.17|P-value:1.73E-9 ID:SGTC_3130|Compound:9127414|FD-Score:6.18|P-value:1.05E-9 ID:SGTC_3133|Compound:9127736|FD-Score:6.07|P-value:1.99E-9 ID:SGTC_3282|Compound:9108498|FD-Score:4.93|P-value:8.63E-7

Top fitness defect scores for YKL056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1875 nocodazole 7.73 6.0 µM 3.74E-14 tubulin folding & SWR complex 18 5.37E-15
2 SGTC_800 3448-7362 7.08 155.0 µM 3.58E-12 translation 22 7.15E-13
3 SGTC_58 0957-0393 7.06 9.0 µM 4.11E-12 cell wall 162 8.29E-13
4 SGTC_3130 9127414 6.18 49.5 µM 1.05E-9 6 3.14E-10
5 SGTC_3123 9126162 6.16 49.5 µM 1.19E-9 3 3.60E-10
6 SGTC_3133 9127736 6.07 49.5 µM 1.99E-9 1 6.23E-10
7 SGTC_2078 5212016 5.10 200.0 µM 3.81E-7 60S ribosome export 3 1.72E-7
8 SGTC_309 k408-0051 4.99 1.5 µM 6.43E-7 28 3.01E-7
9 SGTC_3282 9108498 4.93 15.5 µM 8.63E-7 15 4.12E-7
10 SGTC_3114 9122766 4.72 49.5 µM 2.32E-6 9 1.19E-6
11 SGTC_2062 5245942 4.57 200.0 µM 4.51E-6 6 2.41E-6
12 SGTC_421 streptovitacin 4.47 30.0 mM 6.98E-6 14 3.84E-6
13 SGTC_1292 0kpi-0043 4.13 232.0 µM 3.00E-5 11 1.82E-5
14 SGTC_1346 1488-2224 4.02 62.4 µM 4.58E-5 20 2.85E-5
15 SGTC_832 4083-0019 3.95 164.0 µM 6.07E-5 translation 95 3.85E-5
16 SGTC_377 3970-0964 3.91 33.1 µM 7.24E-5 40 4.64E-5
17 SGTC_1024 4507-0395 3.83 26.0 µM 9.91E-5 TSC3-RPN4 32 6.49E-5
18 SGTC_1293 1000-1278 3.78 195.0 µM 1.20E-4 12 7.92E-5
19 SGTC_103 0844-0104 3.61 51.8 µM 2.20E-4 ERAD & cell cycle 162 1.51E-4
20 SGTC_1916 st067606 3.60 49.2 µM 2.32E-4 53 1.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 2.09E-27 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.151 1.34E-18 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.144 4.14E-17 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.143 6.65E-17 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.138 1.31E-15 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.136 2.49E-15 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.135 4.10E-15 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.131 2.29E-14 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.130 3.59E-14 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.129 5.94E-14 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.128 9.92E-14 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.126 2.19E-13 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.126 2.79E-13 YJR032W CPR7 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
0.122 1.12E-12 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.122 1.38E-12 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly