YKL057C / NUP120

Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL057C / NUP120

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.41|P-value:7.81E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:4.29|P-value:1.18E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.19|P-value:1.63E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.91|P-value:3.74E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.18|P-value:1.74E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.45|P-value:1.51E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:5.60|P-value:7.83E-7 ID:SGTC_462|Compound:ag-879|FD-Score:4.20|P-value:1.58E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.76|P-value:6.39E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.77|P-value:6.13E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:5.91|P-value:2.04E-7 ID:SGTC_751|Compound:0833-0568|FD-Score:4.32|P-value:1.07E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:4.84|P-value:1.65E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:7.14|P-value:4.41E-10 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.64|P-value:8.52E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:6.77|P-value:3.10E-9 ID:SGTC_963|Compound:1269-2853|FD-Score:6.30|P-value:3.25E-8 ID:SGTC_997|Compound:3996-0078|FD-Score:4.76|P-value:2.23E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.65|P-value:8.84E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.78|P-value:5.97E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.79|P-value:5.29E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:-4.54|P-value:4.46E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.39|P-value:1.94E-6 ID:SGTC_1747|Compound:st037496|FD-Score:5.51|P-value:1.16E-6 ID:SGTC_1884|Compound:5633444|FD-Score:-4.63|P-value:3.24E-5 ID:SGTC_1896|Compound:st058441|FD-Score:3.65|P-value:8.83E-4 ID:SGTC_1932|Compound:st074806|FD-Score:5.34|P-value:2.37E-6 ID:SGTC_1983|Compound:st071813|FD-Score:3.88|P-value:4.38E-4 ID:SGTC_1993|Compound:st073995|FD-Score:8.24|P-value:7.61E-13 ID:SGTC_2024|Compound:5144227|FD-Score:3.64|P-value:9.01E-4 ID:SGTC_2033|Compound:5192550|FD-Score:7.38|P-value:1.19E-10 ID:SGTC_2034|Compound:5197015|FD-Score:5.79|P-value:3.43E-7 ID:SGTC_2036|Compound:5160441|FD-Score:3.96|P-value:3.44E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-5.89|P-value:1.96E-7 ID:SGTC_2045|Compound:5106652|FD-Score:-3.62|P-value:8.91E-4 ID:SGTC_2048|Compound:5246248|FD-Score:-7.37|P-value:1.07E-10 ID:SGTC_2064|Compound:5220758|FD-Score:3.62|P-value:9.54E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.82|P-value:5.38E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.14|P-value:1.96E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.97|P-value:3.04E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.73|P-value:6.97E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.72|P-value:6.68E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.60|P-value:7.73E-7 ID:SGTC_2702|Compound:st077768|FD-Score:4.28|P-value:1.23E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.47|P-value:6.42E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.63|P-value:9.50E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.97|P-value:9.14E-6 ID:SGTC_2906|Compound:7926292|FD-Score:-4.77|P-value:1.94E-5 ID:SGTC_2908|Compound:7930301|FD-Score:7.82|P-value:9.54E-12 ID:SGTC_2938|Compound:9059746|FD-Score:-5.05|P-value:6.82E-6 ID:SGTC_3041|Compound:9091929|FD-Score:3.69|P-value:7.83E-4 ID:SGTC_3094|Compound:9117742|FD-Score:4.05|P-value:2.62E-4 ID:SGTC_3274|Compound:9138298|FD-Score:5.26|P-value:3.28E-6 ID:SGTC_3279|Compound:9140807|FD-Score:3.63|P-value:9.51E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.87|P-value:4.61E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.41|P-value:7.81E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:4.29|P-value:1.18E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.19|P-value:1.63E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.91|P-value:3.74E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.18|P-value:1.74E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.45|P-value:1.51E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:5.60|P-value:7.83E-7 ID:SGTC_462|Compound:ag-879|FD-Score:4.20|P-value:1.58E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.76|P-value:6.39E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.77|P-value:6.13E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:5.91|P-value:2.04E-7 ID:SGTC_751|Compound:0833-0568|FD-Score:4.32|P-value:1.07E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:4.84|P-value:1.65E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:7.14|P-value:4.41E-10 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.64|P-value:8.52E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:6.77|P-value:3.10E-9 ID:SGTC_963|Compound:1269-2853|FD-Score:6.30|P-value:3.25E-8 ID:SGTC_997|Compound:3996-0078|FD-Score:4.76|P-value:2.23E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.65|P-value:8.84E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.78|P-value:5.97E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.79|P-value:5.29E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:-4.54|P-value:4.46E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.39|P-value:1.94E-6 ID:SGTC_1747|Compound:st037496|FD-Score:5.51|P-value:1.16E-6 ID:SGTC_1884|Compound:5633444|FD-Score:-4.63|P-value:3.24E-5 ID:SGTC_1896|Compound:st058441|FD-Score:3.65|P-value:8.83E-4 ID:SGTC_1932|Compound:st074806|FD-Score:5.34|P-value:2.37E-6 ID:SGTC_1983|Compound:st071813|FD-Score:3.88|P-value:4.38E-4 ID:SGTC_1993|Compound:st073995|FD-Score:8.24|P-value:7.61E-13 ID:SGTC_2024|Compound:5144227|FD-Score:3.64|P-value:9.01E-4 ID:SGTC_2033|Compound:5192550|FD-Score:7.38|P-value:1.19E-10 ID:SGTC_2034|Compound:5197015|FD-Score:5.79|P-value:3.43E-7 ID:SGTC_2036|Compound:5160441|FD-Score:3.96|P-value:3.44E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-5.89|P-value:1.96E-7 ID:SGTC_2045|Compound:5106652|FD-Score:-3.62|P-value:8.91E-4 ID:SGTC_2048|Compound:5246248|FD-Score:-7.37|P-value:1.07E-10 ID:SGTC_2064|Compound:5220758|FD-Score:3.62|P-value:9.54E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.82|P-value:5.38E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.14|P-value:1.96E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.97|P-value:3.04E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.73|P-value:6.97E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.72|P-value:6.68E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.60|P-value:7.73E-7 ID:SGTC_2702|Compound:st077768|FD-Score:4.28|P-value:1.23E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.47|P-value:6.42E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.63|P-value:9.50E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.97|P-value:9.14E-6 ID:SGTC_2906|Compound:7926292|FD-Score:-4.77|P-value:1.94E-5 ID:SGTC_2908|Compound:7930301|FD-Score:7.82|P-value:9.54E-12 ID:SGTC_2938|Compound:9059746|FD-Score:-5.05|P-value:6.82E-6 ID:SGTC_3041|Compound:9091929|FD-Score:3.69|P-value:7.83E-4 ID:SGTC_3094|Compound:9117742|FD-Score:4.05|P-value:2.62E-4 ID:SGTC_3274|Compound:9138298|FD-Score:5.26|P-value:3.28E-6 ID:SGTC_3279|Compound:9140807|FD-Score:3.63|P-value:9.51E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.87|P-value:4.61E-4

Top fitness defect scores for YKL057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1993 st073995 8.24 70.8 µM 7.61E-13 1 8.57E-17
2 SGTC_2908 7930301 7.82 100.0 µM 9.54E-12 1 2.59E-15
3 SGTC_2033 5192550 7.38 145.0 µM 1.19E-10 1 7.83E-14
4 SGTC_800 3448-7362 7.14 155.0 µM 4.41E-10 translation 21 4.54E-13
5 SGTC_923 1900-2434 6.77 73.3 µM 3.10E-9 RNA processing & uracil transport 7 6.29E-12
6 SGTC_963 1269-2853 6.30 151.0 µM 3.25E-8 4 1.48E-10
7 SGTC_741 4582-0002 5.91 126.0 µM 2.04E-7 2 1.76E-9
8 SGTC_2034 5197015 5.79 53.1 µM 3.43E-7 SWF1 & branched chain AA biosynthesis 9 3.53E-9
9 SGTC_2596 sinensetin 5.60 100.0 µM 7.73E-7 6 1.05E-8
10 SGTC_395 anisomycin 5.60 6.2 µM 7.83E-7 2 1.07E-8
11 SGTC_1747 st037496 5.51 66.6 µM 1.16E-6 5 1.81E-8
12 SGTC_362 0310-0100 5.45 9.0 µM 1.51E-6 RPP1 & pyrimidine depletion 6 2.59E-8
13 SGTC_1506 4226-2149 5.39 212.0 µM 1.94E-6 8 3.61E-8
14 SGTC_1932 st074806 5.34 40.9 µM 2.37E-6 3 4.73E-8
15 SGTC_3274 9138298 5.26 49.5 µM 3.28E-6 4 7.32E-8
16 SGTC_776 4476-4378 4.84 112.0 µM 1.65E-5 ERG2 13 6.41E-7
17 SGTC_997 3996-0078 4.76 137.0 µM 2.23E-5 8 9.53E-7
18 SGTC_2720 fluspirilene 4.47 36.9 µM 6.42E-5 ERG2 8 3.94E-6
19 SGTC_58 0957-0393 4.41 9.0 µM 7.81E-5 cell wall 332 5.12E-6
20 SGTC_751 0833-0568 4.32 350.0 µM 1.07E-4 11 7.83E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.31E-11 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.090 2.03E-7 YDR395W SXM1 hom Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
0.089 2.14E-7 YKR005C_p YKR005C_p hom Putative protein of unknown function
0.089 2.55E-7 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.087 4.12E-7 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.086 5.64E-7 YOR144C ELG1 hom Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
0.085 9.95E-7 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.083 1.48E-6 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication
0.080 3.64E-6 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.077 8.05E-6 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.076 9.18E-6 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.076 1.04E-5 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.076 1.15E-5 YCR043C_p YCR043C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
0.075 1.39E-5 YNR025C_d YNR025C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase
0.075 1.41E-5 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase