YKL060C / FBA1

Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL060C / FBA1

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:2.82|P-value:8.08E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:2.90|P-value:5.88E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:3.00|P-value:3.97E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.49|P-value:4.60E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.50|P-value:4.30E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.62|P-value:2.52E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:2.81|P-value:8.25E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:-2.78|P-value:8.10E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.11|P-value:2.52E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.92|P-value:5.54E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.25|P-value:1.13E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.32|P-value:1.02E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.94|P-value:4.02E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.44|P-value:5.80E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.02|P-value:3.05E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.26|P-value:1.31E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.02|P-value:3.60E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:4.63|P-value:1.04E-7 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.98|P-value:3.30E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.39|P-value:6.24E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:2.79|P-value:9.17E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.61|P-value:2.61E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.69|P-value:1.44E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.90|P-value:1.95E-8 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.20|P-value:1.43E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:2.77|P-value:9.80E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.24|P-value:1.44E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.13|P-value:1.77E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:2.99|P-value:4.10E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.68|P-value:1.84E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:-2.77|P-value:8.23E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.84|P-value:8.26E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.24|P-value:1.43E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.38|P-value:7.48E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:5.89|P-value:1.91E-11 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-2.72|P-value:9.99E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.44|P-value:5.89E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:5.01|P-value:9.36E-9 ID:SGTC_1655|Compound:st012546|FD-Score:3.63|P-value:2.41E-5 ID:SGTC_1739|Compound:st037196|FD-Score:4.07|P-value:2.47E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.78|P-value:1.14E-5 ID:SGTC_1979|Compound:st071809|FD-Score:2.79|P-value:8.91E-4 ID:SGTC_1982|Compound:st072467|FD-Score:2.97|P-value:4.46E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.04|P-value:3.26E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.09|P-value:2.67E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-2.99|P-value:3.46E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.74|P-value:1.15E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.74|P-value:1.35E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.35|P-value:8.85E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.18|P-value:1.56E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.58|P-value:3.04E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.26|P-value:1.31E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.89|P-value:5.28E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.25|P-value:1.38E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.95|P-value:4.85E-6 ID:SGTC_2781|Compound:5567276|FD-Score:2.80|P-value:8.78E-4 ID:SGTC_3090|Compound:9117696|FD-Score:2.80|P-value:8.52E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-2.73|P-value:9.67E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.05|P-value:3.16E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-2.93|P-value:4.47E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:2.82|P-value:8.08E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:2.90|P-value:5.88E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:3.00|P-value:3.97E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.49|P-value:4.60E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.50|P-value:4.30E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.62|P-value:2.52E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:2.81|P-value:8.25E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:-2.78|P-value:8.10E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.11|P-value:2.52E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.92|P-value:5.54E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.25|P-value:1.13E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.32|P-value:1.02E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.94|P-value:4.02E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.44|P-value:5.80E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.02|P-value:3.05E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.26|P-value:1.31E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.02|P-value:3.60E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:4.63|P-value:1.04E-7 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.98|P-value:3.30E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.39|P-value:6.24E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:2.79|P-value:9.17E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.61|P-value:2.61E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.69|P-value:1.44E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.90|P-value:1.95E-8 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.20|P-value:1.43E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:2.77|P-value:9.80E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.24|P-value:1.44E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.13|P-value:1.77E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:2.99|P-value:4.10E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.68|P-value:1.84E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:-2.77|P-value:8.23E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.84|P-value:8.26E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.24|P-value:1.43E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.38|P-value:7.48E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:5.89|P-value:1.91E-11 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-2.72|P-value:9.99E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.44|P-value:5.89E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:5.01|P-value:9.36E-9 ID:SGTC_1655|Compound:st012546|FD-Score:3.63|P-value:2.41E-5 ID:SGTC_1739|Compound:st037196|FD-Score:4.07|P-value:2.47E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.78|P-value:1.14E-5 ID:SGTC_1979|Compound:st071809|FD-Score:2.79|P-value:8.91E-4 ID:SGTC_1982|Compound:st072467|FD-Score:2.97|P-value:4.46E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.04|P-value:3.26E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.09|P-value:2.67E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-2.99|P-value:3.46E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.74|P-value:1.15E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.74|P-value:1.35E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.35|P-value:8.85E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.18|P-value:1.56E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.58|P-value:3.04E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.26|P-value:1.31E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.89|P-value:5.28E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.25|P-value:1.38E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.95|P-value:4.85E-6 ID:SGTC_2781|Compound:5567276|FD-Score:2.80|P-value:8.78E-4 ID:SGTC_3090|Compound:9117696|FD-Score:2.80|P-value:8.52E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-2.73|P-value:9.67E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.05|P-value:3.16E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-2.93|P-value:4.47E-4

Top fitness defect scores for YKL060C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1533 dihydroergotamine mesylate 5.89 29.4 µM 1.91E-11 DNA intercalators 2 1.97E-9 0.95
2 SGTC_1562 morin hydrate 5.01 59.1 µM 9.36E-9 2 2.72E-7 0.01
3 SGTC_1020 4335-0961 4.90 93.3 µM 1.95E-8 3 4.88E-7 0.22
4 SGTC_807 1315-0151 4.63 48.0 µM 1.04E-7 4 1.85E-6 0.59
5 SGTC_1134 3477-0009 4.13 42.5 µM 1.77E-6 9 1.78E-5 0.05
6 SGTC_1739 st037196 4.07 92.5 µM 2.47E-6 3 2.32E-5 0.41
7 SGTC_2780 5215298 3.95 71.4 µM 4.85E-6 14 3.98E-5 0.08
8 SGTC_300 r073-0011 3.92 5.0 µM 5.54E-6 1 4.43E-5 0.21
9 SGTC_1229 0139-0193 3.84 12.2 µM 8.26E-6 RSC complex & mRNA processing 20 6.09E-5 0.01
10 SGTC_1787 fluconazole 3.78 80.0 µM 1.14E-5 iron homeostasis 12 7.87E-5 0.12
11 SGTC_2329 6138490 3.74 200.0 µM 1.35E-5 15 9.04E-5 0.01
12 SGTC_1158 4092-0494 3.68 91.8 µM 1.84E-5 8 1.16E-4 0.23
13 SGTC_1655 st012546 3.63 55.1 µM 2.41E-5 8 1.44E-4 0.13
14 SGTC_145 3737-0113 3.62 38.4 µM 2.52E-5 DNA intercalators 59 1.49E-4 0.01
15 SGTC_1016 4226-1401 3.61 38.0 µM 2.61E-5 RNA pol III & RNase P/MRP 21 1.53E-4 0.23
16 SGTC_2608 thymoquinone 3.58 42.7 µM 3.04E-5 5 1.73E-4 9.98E-4
17 SGTC_143 4032-1194 3.50 15.7 µM 4.30E-5 28 2.29E-4 0.04
18 SGTC_116 0155-0182 3.49 31.8 µM 4.60E-5 mitochondrial response to ROS 8 2.41E-4 0.21
19 SGTC_391 gliotoxin 3.44 8.3 µM 5.80E-5 7 2.90E-4 0.06
20 SGTC_1544 7-methoxy-4-methylcoumarin 3.44 105.0 µM 5.89E-5 9 2.94E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.97E-11 YDL182W LYS20 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.110 1.81E-10 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.106 6.22E-10 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.103 2.18E-9 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.102 2.63E-9 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.101 3.86E-9 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.094 5.50E-8 YCR025C_d YCR025C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
0.088 3.56E-7 YPL075W GCR1 het Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
0.088 3.64E-7 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.083 1.37E-6 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.083 1.42E-6 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.083 1.51E-6 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.081 2.80E-6 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.077 7.97E-6 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.076 1.12E-5 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1