YKL062W / MSN4

Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL062W / MSN4

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:2.98|P-value:9.80E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:-4.76|P-value:2.73E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:3.59|P-value:9.64E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:3.67|P-value:6.91E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.99|P-value:1.63E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:3.95|P-value:1.98E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:3.17|P-value:5.03E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.09|P-value:5.56E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.01|P-value:7.40E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-3.62|P-value:6.89E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.57|P-value:8.45E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:-3.95|P-value:1.60E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.63|P-value:8.14E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.17|P-value:4.89E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.23|P-value:4.35E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.53|P-value:1.23E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.13|P-value:4.90E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-2.93|P-value:9.98E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.10|P-value:6.51E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.88|P-value:2.20E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-3.94|P-value:1.71E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.42|P-value:1.90E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.29|P-value:3.11E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.48|P-value:1.53E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.42|P-value:1.89E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.60|P-value:8.33E-7 ID:SGTC_2823|Compound:7987624|FD-Score:-3.32|P-value:2.36E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.59|P-value:7.89E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-3.22|P-value:3.46E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.30|P-value:3.02E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.90|P-value:1.98E-5 ID:SGTC_3087|Compound:9117406|FD-Score:-3.90|P-value:1.98E-5 ID:SGTC_3089|Compound:9117425|FD-Score:4.14|P-value:8.17E-6 ID:SGTC_3096|Compound:9117468|FD-Score:3.84|P-value:3.29E-5 ID:SGTC_3097|Compound:9117246|FD-Score:4.33|P-value:3.35E-6 ID:SGTC_3249|Compound:9135183|FD-Score:3.12|P-value:5.99E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.62|P-value:7.54E-7 ID:SGTC_3305|Compound:9127027|FD-Score:-4.05|P-value:1.01E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:2.98|P-value:9.80E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:-4.76|P-value:2.73E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:3.59|P-value:9.64E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:3.67|P-value:6.91E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.99|P-value:1.63E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:3.95|P-value:1.98E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:3.17|P-value:5.03E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.09|P-value:5.56E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.01|P-value:7.40E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-3.62|P-value:6.89E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.57|P-value:8.45E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:-3.95|P-value:1.60E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.63|P-value:8.14E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.17|P-value:4.89E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.23|P-value:4.35E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.53|P-value:1.23E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.13|P-value:4.90E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-2.93|P-value:9.98E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.10|P-value:6.51E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.88|P-value:2.20E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-3.94|P-value:1.71E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.42|P-value:1.90E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.29|P-value:3.11E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.48|P-value:1.53E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.42|P-value:1.89E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.60|P-value:8.33E-7 ID:SGTC_2823|Compound:7987624|FD-Score:-3.32|P-value:2.36E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.59|P-value:7.89E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-3.22|P-value:3.46E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.30|P-value:3.02E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.90|P-value:1.98E-5 ID:SGTC_3087|Compound:9117406|FD-Score:-3.90|P-value:1.98E-5 ID:SGTC_3089|Compound:9117425|FD-Score:4.14|P-value:8.17E-6 ID:SGTC_3096|Compound:9117468|FD-Score:3.84|P-value:3.29E-5 ID:SGTC_3097|Compound:9117246|FD-Score:4.33|P-value:3.35E-6 ID:SGTC_3249|Compound:9135183|FD-Score:3.12|P-value:5.99E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.62|P-value:7.54E-7 ID:SGTC_3305|Compound:9127027|FD-Score:-4.05|P-value:1.01E-5

Top fitness defect scores for YKL062W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3300 9124615 4.62 50.5 µM 7.54E-7 8 1.92E-6
2 SGTC_2781 5567276 4.60 71.4 µM 8.33E-7 28 2.10E-6
3 SGTC_1951 sophoraflavanone G 4.53 9.2 µM 1.23E-6 RNA processing & uracil transport 12 3.00E-6
4 SGTC_2634 4'-methoxyflavone 4.48 100.0 µM 1.53E-6 22 3.69E-6
5 SGTC_3097 9117246 4.33 49.5 µM 3.35E-6 5 7.57E-6
6 SGTC_3089 9117425 4.14 49.5 µM 8.17E-6 18 1.72E-5
7 SGTC_446 go6976 3.99 132.0 µM 1.63E-5 12 3.25E-5
8 SGTC_552 k242-0005 3.95 476.0 µM 1.98E-5 15 3.89E-5
9 SGTC_3096 9117468 3.84 49.5 µM 3.29E-5 5 6.22E-5
10 SGTC_322 k048-0136 3.67 19.3 µM 6.91E-5 RSC & ERG11 20 1.23E-4
11 SGTC_1250 0485-0349 3.63 40.2 µM 8.14E-5 45 1.44E-4
12 SGTC_319 1348-1596 3.59 45.5 µM 9.64E-5 RSC & ERG11 26 1.68E-4
13 SGTC_2724 maprotiline 3.42 69.6 µM 1.89E-4 ERG2 26 3.12E-4
14 SGTC_2454 5-benzylidenerhodanine 3.42 10.4 µM 1.90E-4 TRP & mitochondrial translation 68 3.15E-4
15 SGTC_2982 9019404 3.30 26.0 µM 3.02E-4 40 4.81E-4
16 SGTC_2629 bisabolol 3.29 100.0 µM 3.11E-4 47 4.95E-4
17 SGTC_1790 st045711 3.17 43.5 µM 4.89E-4 33 7.52E-4
18 SGTC_896 0964-0007 3.17 44.5 µM 5.03E-4 29 7.73E-4
19 SGTC_3249 9135183 3.12 49.5 µM 5.99E-4 60S ribosome export 43 9.07E-4
20 SGTC_2155 5570423 3.10 76.0 µM 6.51E-4 ergosterol biosynthesis 38 9.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.97E-8 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.076 1.18E-5 YJL078C PRY3 hom Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
0.073 2.36E-5 YIR018W YAP5 hom Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication
0.069 5.68E-5 YOR063W RPL3 het Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
0.069 7.12E-5 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.068 7.33E-5 YMR206W_p YMR206W_p hom Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication
0.068 7.73E-5 YMR135C GID8 hom Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START
0.067 9.96E-5 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.067 1.13E-4 YER045C ACA1 hom ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication
0.066 1.34E-4 YMR088C VBA1 hom Permease of basic amino acids in the vacuolar membrane
0.066 1.26E-4 YEL006W YEA6 hom Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
0.066 1.41E-4 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.065 1.67E-4 YBR220C_p YBR220C_p hom Putative protein of unknown function; YBR220C is not an essential gene
0.065 1.81E-4 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.064 2.16E-4 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA