YKL064W / MNR2

Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL064W / MNR2

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.72|P-value:5.01E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-4.15|P-value:6.61E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:3.02|P-value:8.15E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.99|P-value:8.42E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.61|P-value:7.42E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.55|P-value:1.03E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:5.34|P-value:1.17E-8 ID:SGTC_917|Compound:harmaline|FD-Score:3.78|P-value:3.95E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.09|P-value:5.78E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.28|P-value:3.06E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.21|P-value:3.95E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.87|P-value:2.68E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.15|P-value:4.94E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.38|P-value:2.08E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.76|P-value:3.90E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.91|P-value:2.20E-5 ID:SGTC_1827|Compound:berberine|FD-Score:-3.81|P-value:3.11E-5 ID:SGTC_1961|Compound:st076550|FD-Score:-3.02|P-value:7.53E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.03|P-value:7.21E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.05|P-value:7.23E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.76|P-value:3.17E-7 ID:SGTC_2305|Compound:7443522|FD-Score:3.05|P-value:7.38E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.82|P-value:5.62E-10 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.09|P-value:5.71E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.20|P-value:4.11E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.97|P-value:1.71E-5 ID:SGTC_2696|Compound:st077691|FD-Score:3.10|P-value:6.09E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.48|P-value:1.41E-6 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.86|P-value:2.80E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.54|P-value:9.92E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.14|P-value:4.85E-4 ID:SGTC_2811|Compound:7967822|FD-Score:4.71|P-value:4.30E-7 ID:SGTC_2825|Compound:7998094|FD-Score:3.33|P-value:2.57E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-2.97|P-value:8.97E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.22|P-value:3.91E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.72|P-value:5.01E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-4.15|P-value:6.61E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:3.02|P-value:8.15E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.99|P-value:8.42E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.61|P-value:7.42E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.55|P-value:1.03E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:5.34|P-value:1.17E-8 ID:SGTC_917|Compound:harmaline|FD-Score:3.78|P-value:3.95E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.09|P-value:5.78E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.28|P-value:3.06E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.21|P-value:3.95E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.87|P-value:2.68E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.15|P-value:4.94E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.38|P-value:2.08E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.76|P-value:3.90E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.91|P-value:2.20E-5 ID:SGTC_1827|Compound:berberine|FD-Score:-3.81|P-value:3.11E-5 ID:SGTC_1961|Compound:st076550|FD-Score:-3.02|P-value:7.53E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.03|P-value:7.21E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.05|P-value:7.23E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.76|P-value:3.17E-7 ID:SGTC_2305|Compound:7443522|FD-Score:3.05|P-value:7.38E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.82|P-value:5.62E-10 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.09|P-value:5.71E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.20|P-value:4.11E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.97|P-value:1.71E-5 ID:SGTC_2696|Compound:st077691|FD-Score:3.10|P-value:6.09E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.48|P-value:1.41E-6 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.86|P-value:2.80E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.54|P-value:9.92E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.14|P-value:4.85E-4 ID:SGTC_2811|Compound:7967822|FD-Score:4.71|P-value:4.30E-7 ID:SGTC_2825|Compound:7998094|FD-Score:3.33|P-value:2.57E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-2.97|P-value:8.97E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.22|P-value:3.91E-4

Top fitness defect scores for YKL064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2607 solasodine 5.82 47.4 µM 5.62E-10 30 2.89E-9
2 SGTC_865 0488-0499 5.34 301.0 µM 1.17E-8 5 4.62E-8
3 SGTC_2250 alverine citrate 4.76 130.0 µM 3.17E-7 107 9.51E-7
4 SGTC_2811 7967822 4.71 32.5 µM 4.30E-7 8 1.26E-6
5 SGTC_2758 dehydroepiandrosterone 4.48 69.3 µM 1.41E-6 28 3.73E-6
6 SGTC_2687 chenodiol 3.97 100.0 µM 1.71E-5 23 3.66E-5
7 SGTC_1584 6-fluoro-dl-tryptophan 3.91 90.0 µM 2.20E-5 mitochondrial processes 12 4.63E-5
8 SGTC_1233 0325-0408 3.87 14.2 µM 2.68E-5 22 5.54E-5
9 SGTC_2770 toltrazuril 3.86 17.5 µM 2.80E-5 31 5.77E-5
10 SGTC_917 harmaline 3.78 728.1 nM 3.95E-5 ergosterol biosynthesis 29 7.92E-5
11 SGTC_87 0100-0052 3.72 35.5 µM 5.01E-5 128 9.84E-5
12 SGTC_676 falcarinol 3.55 140.0 µM 1.03E-4 69 1.91E-4
13 SGTC_1424 4048-1941 3.38 275.0 µM 2.08E-4 42 3.63E-4
14 SGTC_2825 7998094 3.33 58.4 µM 2.57E-4 fatty acid desaturase (OLE1) 51 4.41E-4
15 SGTC_1195 1502-0147 3.28 41.1 µM 3.06E-4 53 5.19E-4
16 SGTC_3141 9094609 3.22 49.5 µM 3.91E-4 iron homeostasis 66 6.49E-4
17 SGTC_1196 1588-0294 3.21 184.0 µM 3.95E-4 34 6.55E-4
18 SGTC_2621 lithochol-11-enic acid 3.20 100.0 µM 4.11E-4 64 6.79E-4
19 SGTC_1287 0971-0001 3.15 34.6 µM 4.94E-4 sphingolipid biosynthesis & PDR1 77 8.04E-4
20 SGTC_2696 st077691 3.10 74.3 µM 6.09E-4 66 9.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.69E-13 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.123 1.17E-12 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.115 2.61E-11 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.103 2.26E-9 YNL324W_d YNL324W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.64E-9 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.101 5.37E-9 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.100 7.86E-9 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.099 8.71E-9 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.099 8.79E-9 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.096 2.97E-8 YPR082C DIB1 het 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
0.093 5.87E-8 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress
0.092 9.91E-8 YOL112W MSB4 hom GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization
0.091 1.32E-7 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.090 1.80E-7 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.088 3.03E-7 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly