YKL065C / YET1

Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL065C / YET1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:5.49|P-value:7.14E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.30|P-value:1.46E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.19|P-value:2.20E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.79|P-value:1.45E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.52|P-value:5.14E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:3.70|P-value:2.31E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.55|P-value:4.59E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.48|P-value:6.29E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.52|P-value:5.29E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:4.02|P-value:4.72E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.38|P-value:9.53E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:3.28|P-value:1.52E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.55|P-value:2.92E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:-4.41|P-value:6.38E-7 ID:SGTC_836|Compound:0330-0104|FD-Score:3.78|P-value:1.56E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:-2.83|P-value:9.43E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:2.90|P-value:6.97E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.71|P-value:2.19E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.57|P-value:4.20E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.31|P-value:1.32E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.05|P-value:4.03E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:2.81|P-value:9.64E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.19|P-value:2.16E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:2.81|P-value:9.58E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.20|P-value:2.10E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.62|P-value:3.53E-5 ID:SGTC_1851|Compound:st056236|FD-Score:2.98|P-value:5.08E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.65|P-value:3.12E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.20|P-value:2.08E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.60|P-value:3.83E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.43|P-value:7.96E-5 ID:SGTC_2203|Compound:7227154|FD-Score:-2.98|P-value:5.43E-4 ID:SGTC_2211|Compound:7117706|FD-Score:-4.37|P-value:7.69E-7 ID:SGTC_2257|Compound:7960413|FD-Score:4.24|P-value:1.51E-6 ID:SGTC_2302|Compound:7771753|FD-Score:-4.07|P-value:3.91E-6 ID:SGTC_2321|Compound:7390090|FD-Score:2.88|P-value:7.44E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.39|P-value:9.32E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-3.03|P-value:4.33E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-2.88|P-value:7.92E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.84|P-value:8.99E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.54|P-value:4.72E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.37|P-value:7.24E-7 ID:SGTC_2825|Compound:7998094|FD-Score:3.77|P-value:1.63E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.58|P-value:4.19E-5 ID:SGTC_2841|Compound:9004761|FD-Score:-3.30|P-value:1.46E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.88|P-value:1.02E-5 ID:SGTC_2858|Compound:9025781|FD-Score:5.21|P-value:4.71E-9 ID:SGTC_2950|Compound:9072895|FD-Score:-4.36|P-value:8.37E-7 ID:SGTC_3024|Compound:9090631|FD-Score:3.97|P-value:5.98E-6 ID:SGTC_3030|Compound:9087619|FD-Score:-3.58|P-value:4.21E-5 ID:SGTC_3041|Compound:9091929|FD-Score:-2.86|P-value:8.56E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-2.82|P-value:9.68E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.26|P-value:1.62E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.05|P-value:4.03E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:5.49|P-value:7.14E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.30|P-value:1.46E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.19|P-value:2.20E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.79|P-value:1.45E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.52|P-value:5.14E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:3.70|P-value:2.31E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.55|P-value:4.59E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.48|P-value:6.29E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.52|P-value:5.29E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:4.02|P-value:4.72E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.38|P-value:9.53E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:3.28|P-value:1.52E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.55|P-value:2.92E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:-4.41|P-value:6.38E-7 ID:SGTC_836|Compound:0330-0104|FD-Score:3.78|P-value:1.56E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:-2.83|P-value:9.43E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:2.90|P-value:6.97E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.71|P-value:2.19E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.57|P-value:4.20E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.31|P-value:1.32E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.05|P-value:4.03E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:2.81|P-value:9.64E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.19|P-value:2.16E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:2.81|P-value:9.58E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.20|P-value:2.10E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.62|P-value:3.53E-5 ID:SGTC_1851|Compound:st056236|FD-Score:2.98|P-value:5.08E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.65|P-value:3.12E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.20|P-value:2.08E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.60|P-value:3.83E-5 ID:SGTC_1972|Compound:st070201|FD-Score:3.43|P-value:7.96E-5 ID:SGTC_2203|Compound:7227154|FD-Score:-2.98|P-value:5.43E-4 ID:SGTC_2211|Compound:7117706|FD-Score:-4.37|P-value:7.69E-7 ID:SGTC_2257|Compound:7960413|FD-Score:4.24|P-value:1.51E-6 ID:SGTC_2302|Compound:7771753|FD-Score:-4.07|P-value:3.91E-6 ID:SGTC_2321|Compound:7390090|FD-Score:2.88|P-value:7.44E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.39|P-value:9.32E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-3.03|P-value:4.33E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-2.88|P-value:7.92E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.84|P-value:8.99E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.54|P-value:4.72E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.37|P-value:7.24E-7 ID:SGTC_2825|Compound:7998094|FD-Score:3.77|P-value:1.63E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.58|P-value:4.19E-5 ID:SGTC_2841|Compound:9004761|FD-Score:-3.30|P-value:1.46E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.88|P-value:1.02E-5 ID:SGTC_2858|Compound:9025781|FD-Score:5.21|P-value:4.71E-9 ID:SGTC_2950|Compound:9072895|FD-Score:-4.36|P-value:8.37E-7 ID:SGTC_3024|Compound:9090631|FD-Score:3.97|P-value:5.98E-6 ID:SGTC_3030|Compound:9087619|FD-Score:-3.58|P-value:4.21E-5 ID:SGTC_3041|Compound:9091929|FD-Score:-2.86|P-value:8.56E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-2.82|P-value:9.68E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.26|P-value:1.62E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.05|P-value:4.03E-4

Top fitness defect scores for YKL065C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_43 0570-0105 5.49 72.5 µM 7.14E-10 ERG2 46 1.97E-8
2 SGTC_2858 9025781 5.21 9.0 µM 4.71E-9 sphingolipid biosynthesis & PDR1 60 9.43E-8
3 SGTC_2787 5284540 4.37 71.4 µM 7.24E-7 18 6.16E-6
4 SGTC_2257 7960413 4.24 200.0 µM 1.51E-6 NEO1-PIK1 46 1.13E-5
5 SGTC_687 k029-0044 4.02 34.9 µM 4.72E-6 PDR1 16 2.93E-5
6 SGTC_3024 9090631 3.97 49.5 µM 5.98E-6 9 3.57E-5
7 SGTC_114 0364-0001 3.79 490.3 µM 1.45E-5 60 7.43E-5
8 SGTC_836 0330-0104 3.78 1.4 µM 1.56E-5 21 7.92E-5
9 SGTC_2825 7998094 3.77 58.4 µM 1.63E-5 fatty acid desaturase (OLE1) 37 8.19E-5
10 SGTC_984 1492-0255 3.71 2.9 µM 2.19E-5 SWF1 & branched chain AA biosynthesis 33 1.05E-4
11 SGTC_193 1273-0060 3.70 1.6 µM 2.31E-5 ergosterol biosynthesis 13 1.10E-4
12 SGTC_1012 4112-3522 3.57 18.0 µM 4.20E-5 30 1.80E-4
13 SGTC_212 3807-4682 3.55 38.8 µM 4.59E-5 tubulin folding & SWR complex 93 1.94E-4
14 SGTC_2676 harmalol 3.54 100.0 µM 4.72E-5 mitochondrial processes 22 1.99E-4
15 SGTC_143 4032-1194 3.52 15.7 µM 5.14E-5 87 2.13E-4
16 SGTC_670 4204-0025 3.52 119.0 µM 5.29E-5 copper-dependent oxidative stress 45 2.19E-4
17 SGTC_226 1,3-diallylurea 3.48 8.3 mM 6.29E-5 20 2.53E-4
18 SGTC_1972 st070201 3.43 17.4 µM 7.96E-5 39 3.07E-4
19 SGTC_2322 7413319 3.39 38.2 µM 9.32E-5 ERAD & cell cycle 196 3.51E-4
20 SGTC_815 1582-0027 3.38 36.9 µM 9.53E-5 57 3.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 3.80E-16 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.112 7.70E-11 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.111 1.17E-10 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.111 1.19E-10 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.110 2.00E-10 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.106 6.13E-10 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.104 1.66E-9 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 2.29E-9 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.103 2.38E-9 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.102 2.76E-9 YGR178C PBP1 hom Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.100 6.71E-9 YDR391C_p YDR391C_p hom Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.099 8.40E-9 YDL122W UBP1 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.098 1.51E-8 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.095 4.09E-8 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.093 7.80E-8 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin