YKL068W / NUP100

FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL068W / NUP100

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.53|P-value:1.20E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.28|P-value:3.76E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.01|P-value:8.40E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:-3.14|P-value:6.23E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:2.99|P-value:9.02E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.33|P-value:2.58E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:5.06|P-value:7.41E-8 ID:SGTC_632|Compound:0781-2353|FD-Score:-3.49|P-value:1.65E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.27|P-value:3.25E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.46|P-value:1.59E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.66|P-value:6.95E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.25|P-value:4.18E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.23|P-value:3.80E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.00|P-value:8.70E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.32|P-value:2.73E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.62|P-value:8.27E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.03|P-value:7.87E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.40|P-value:2.01E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.15|P-value:8.07E-6 ID:SGTC_1909|Compound:st060837|FD-Score:-3.55|P-value:1.29E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.97|P-value:2.23E-5 ID:SGTC_1997|Compound:st073024|FD-Score:3.42|P-value:1.86E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.86|P-value:2.95E-5 ID:SGTC_2208|Compound:7283366|FD-Score:3.16|P-value:4.94E-4 ID:SGTC_2229|Compound:7354935|FD-Score:5.87|P-value:5.33E-10 ID:SGTC_2300|Compound:7976697|FD-Score:3.88|P-value:2.72E-5 ID:SGTC_2301|Compound:7769476|FD-Score:3.34|P-value:2.49E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.71|P-value:5.54E-5 ID:SGTC_2390|Compound:9097792|FD-Score:-3.01|P-value:9.96E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.19|P-value:6.41E-6 ID:SGTC_2625|Compound:euphol|FD-Score:3.65|P-value:7.34E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.81|P-value:3.73E-5 ID:SGTC_2890|Compound:9046729|FD-Score:-3.36|P-value:2.76E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.69|P-value:6.08E-5 ID:SGTC_3029|Compound:9088683|FD-Score:2.98|P-value:9.32E-4 ID:SGTC_3076|Compound:9116187|FD-Score:4.90|P-value:1.77E-7 ID:SGTC_3242|Compound:9133940|FD-Score:3.58|P-value:9.55E-5 ID:SGTC_3263|Compound:9137018|FD-Score:3.49|P-value:1.38E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.53|P-value:1.20E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.28|P-value:3.76E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.01|P-value:8.40E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:-3.14|P-value:6.23E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:2.99|P-value:9.02E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.33|P-value:2.58E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:5.06|P-value:7.41E-8 ID:SGTC_632|Compound:0781-2353|FD-Score:-3.49|P-value:1.65E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.27|P-value:3.25E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.46|P-value:1.59E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.66|P-value:6.95E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.25|P-value:4.18E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.23|P-value:3.80E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.00|P-value:8.70E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.32|P-value:2.73E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.62|P-value:8.27E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.03|P-value:7.87E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.40|P-value:2.01E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.15|P-value:8.07E-6 ID:SGTC_1909|Compound:st060837|FD-Score:-3.55|P-value:1.29E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.97|P-value:2.23E-5 ID:SGTC_1997|Compound:st073024|FD-Score:3.42|P-value:1.86E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.86|P-value:2.95E-5 ID:SGTC_2208|Compound:7283366|FD-Score:3.16|P-value:4.94E-4 ID:SGTC_2229|Compound:7354935|FD-Score:5.87|P-value:5.33E-10 ID:SGTC_2300|Compound:7976697|FD-Score:3.88|P-value:2.72E-5 ID:SGTC_2301|Compound:7769476|FD-Score:3.34|P-value:2.49E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.71|P-value:5.54E-5 ID:SGTC_2390|Compound:9097792|FD-Score:-3.01|P-value:9.96E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.19|P-value:6.41E-6 ID:SGTC_2625|Compound:euphol|FD-Score:3.65|P-value:7.34E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.81|P-value:3.73E-5 ID:SGTC_2890|Compound:9046729|FD-Score:-3.36|P-value:2.76E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.69|P-value:6.08E-5 ID:SGTC_3029|Compound:9088683|FD-Score:2.98|P-value:9.32E-4 ID:SGTC_3076|Compound:9116187|FD-Score:4.90|P-value:1.77E-7 ID:SGTC_3242|Compound:9133940|FD-Score:3.58|P-value:9.55E-5 ID:SGTC_3263|Compound:9137018|FD-Score:3.49|P-value:1.38E-4

Top fitness defect scores for YKL068W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2229 7354935 5.87 190.0 µM 5.33E-10 RSC complex & mRNA processing 2 2.15E-9
2 SGTC_579 4491-1009 5.06 110.0 µM 7.41E-8 60S ribosome export 7 2.14E-7
3 SGTC_3076 9116187 4.90 49.5 µM 1.77E-7 6 4.81E-7
4 SGTC_2514 salinomycin 4.19 42.7 µM 6.41E-6 35 1.37E-5
5 SGTC_1717 st033143 4.15 58.0 µM 8.07E-6 36 1.70E-5
6 SGTC_2300 7976697 3.88 71.6 µM 2.72E-5 ERG2 33 5.26E-5
7 SGTC_2191 5911152 3.86 200.0 µM 2.95E-5 17 5.67E-5
8 SGTC_2760 etidronate 3.81 98.0 µM 3.73E-5 32 7.06E-5
9 SGTC_2385 9074692 3.71 200.0 µM 5.54E-5 53 1.02E-4
10 SGTC_2999 9069765 3.69 71.4 µM 6.08E-5 amide catabolism 37 1.11E-4
11 SGTC_948 3448-0295 3.66 75.3 µM 6.95E-5 38 1.26E-4
12 SGTC_2625 euphol 3.65 100.0 µM 7.34E-5 36 1.33E-4
13 SGTC_1422 4031-0024 3.62 15.5 µM 8.27E-5 iron homeostasis 22 1.49E-4
14 SGTC_3242 9133940 3.58 49.5 µM 9.55E-5 17 1.70E-4
15 SGTC_15 0266-0086 3.53 27.1 µM 1.20E-4 endomembrane recycling 81 2.11E-4
16 SGTC_3263 9137018 3.49 49.5 µM 1.38E-4 31 2.39E-4
17 SGTC_799 1310-0557 3.46 151.0 µM 1.59E-4 superoxide 42 2.73E-4
18 SGTC_1997 st073024 3.42 93.8 µM 1.86E-4 18 3.16E-4
19 SGTC_1496 4469-0713 3.40 57.4 µM 2.01E-4 35 3.40E-4
20 SGTC_2301 7769476 3.34 200.0 µM 2.49E-4 36 4.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.59E-13 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.094 5.47E-8 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.090 1.63E-7 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.085 7.51E-7 YBL072C RPS8A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication
0.084 1.19E-6 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.084 1.23E-6 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.081 3.02E-6 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.078 5.97E-6 YGL238W CSE1 het Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
0.078 5.93E-6 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.078 6.40E-6 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.078 6.63E-6 YNL273W TOF1 hom Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
0.078 6.73E-6 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.074 1.86E-5 YDR318W MCM21 hom Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2
0.072 3.38E-5 YOL069W NUF2 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.071 3.61E-5 YML005W TRM12 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA