YKL068W-A_p

Putative protein of unknown function; identified by homology to Ashbya gossypii

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL068W-A / YKL068W-A

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:7.39|P-value:1.00E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:6.89|P-value:1.48E-9 ID:SGTC_87|Compound:0100-0052|FD-Score:3.98|P-value:3.36E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:7.80|P-value:9.05E-12 ID:SGTC_127|Compound:0180-0333|FD-Score:4.32|P-value:1.06E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:22.70|P-value:1.24E-86 ID:SGTC_173|Compound:1273-0061|FD-Score:5.49|P-value:1.19E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:18.40|P-value:3.99E-57 ID:SGTC_275|Compound:trichlorophene|FD-Score:14.20|P-value:5.18E-35 ID:SGTC_283|Compound:0987-0079|FD-Score:3.66|P-value:8.81E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:14.10|P-value:2.13E-34 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.27|P-value:8.48E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.79|P-value:5.92E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.86|P-value:1.51E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:6.30|P-value:3.02E-8 ID:SGTC_608|Compound:k048-0125|FD-Score:-4.17|P-value:1.23E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:5.98|P-value:1.38E-7 ID:SGTC_721|Compound:1187-1332|FD-Score:4.32|P-value:1.09E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.95|P-value:1.07E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.86|P-value:1.52E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.64|P-value:6.64E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.32|P-value:1.09E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.38|P-value:8.85E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.08|P-value:6.46E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:4.28|P-value:1.23E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.99|P-value:2.22E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.62|P-value:7.12E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.83|P-value:5.27E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.24|P-value:9.42E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-4.56|P-value:3.07E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.04|P-value:2.74E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:4.41|P-value:8.00E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.17|P-value:4.45E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:6.15|P-value:6.09E-8 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.19|P-value:1.13E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.68|P-value:8.42E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.71|P-value:7.64E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.94|P-value:3.74E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.30|P-value:1.61E-26 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.54|P-value:9.08E-4 ID:SGTC_1722|Compound:st034304|FD-Score:5.80|P-value:3.04E-7 ID:SGTC_1723|Compound:st034307|FD-Score:4.60|P-value:4.07E-5 ID:SGTC_1742|Compound:st038235|FD-Score:5.64|P-value:6.20E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.16|P-value:2.92E-6 ID:SGTC_1800|Compound:st050079|FD-Score:-4.09|P-value:1.62E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-3.51|P-value:9.79E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.21|P-value:1.05E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.11|P-value:5.83E-6 ID:SGTC_1921|Compound:5740136|FD-Score:8.26|P-value:5.47E-13 ID:SGTC_1922|Compound:5578187|FD-Score:4.01|P-value:3.01E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-5.59|P-value:4.76E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.65|P-value:9.18E-4 ID:SGTC_2287|Compound:7945887|FD-Score:4.53|P-value:5.08E-5 ID:SGTC_2326|Compound:6164455|FD-Score:4.04|P-value:2.74E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.15|P-value:1.89E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-4.42|P-value:5.05E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.64|P-value:6.72E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.58|P-value:7.90E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.69|P-value:7.96E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.50|P-value:3.81E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.27|P-value:1.28E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-4.13|P-value:1.38E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.35|P-value:1.35E-6 ID:SGTC_2940|Compound:9060638|FD-Score:4.08|P-value:2.39E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.92|P-value:3.97E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-4.84|P-value:1.06E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-3.77|P-value:4.44E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.13|P-value:1.38E-4 ID:SGTC_3275|Compound:9138069|FD-Score:4.23|P-value:1.44E-4 ID:SGTC_3310|Compound:9130229|FD-Score:4.38|P-value:8.69E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:7.39|P-value:1.00E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:6.89|P-value:1.48E-9 ID:SGTC_87|Compound:0100-0052|FD-Score:3.98|P-value:3.36E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:7.80|P-value:9.05E-12 ID:SGTC_127|Compound:0180-0333|FD-Score:4.32|P-value:1.06E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:22.70|P-value:1.24E-86 ID:SGTC_173|Compound:1273-0061|FD-Score:5.49|P-value:1.19E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:18.40|P-value:3.99E-57 ID:SGTC_275|Compound:trichlorophene|FD-Score:14.20|P-value:5.18E-35 ID:SGTC_283|Compound:0987-0079|FD-Score:3.66|P-value:8.81E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:14.10|P-value:2.13E-34 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.27|P-value:8.48E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.79|P-value:5.92E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.86|P-value:1.51E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:6.30|P-value:3.02E-8 ID:SGTC_608|Compound:k048-0125|FD-Score:-4.17|P-value:1.23E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:5.98|P-value:1.38E-7 ID:SGTC_721|Compound:1187-1332|FD-Score:4.32|P-value:1.09E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.95|P-value:1.07E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.86|P-value:1.52E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.64|P-value:6.64E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.32|P-value:1.09E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.38|P-value:8.85E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.08|P-value:6.46E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:4.28|P-value:1.23E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.99|P-value:2.22E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.62|P-value:7.12E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.83|P-value:5.27E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.24|P-value:9.42E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-4.56|P-value:3.07E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.04|P-value:2.74E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:4.41|P-value:8.00E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.17|P-value:4.45E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:6.15|P-value:6.09E-8 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.19|P-value:1.13E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.68|P-value:8.42E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.71|P-value:7.64E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.94|P-value:3.74E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.30|P-value:1.61E-26 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.54|P-value:9.08E-4 ID:SGTC_1722|Compound:st034304|FD-Score:5.80|P-value:3.04E-7 ID:SGTC_1723|Compound:st034307|FD-Score:4.60|P-value:4.07E-5 ID:SGTC_1742|Compound:st038235|FD-Score:5.64|P-value:6.20E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.16|P-value:2.92E-6 ID:SGTC_1800|Compound:st050079|FD-Score:-4.09|P-value:1.62E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-3.51|P-value:9.79E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.21|P-value:1.05E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.11|P-value:5.83E-6 ID:SGTC_1921|Compound:5740136|FD-Score:8.26|P-value:5.47E-13 ID:SGTC_1922|Compound:5578187|FD-Score:4.01|P-value:3.01E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-5.59|P-value:4.76E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.65|P-value:9.18E-4 ID:SGTC_2287|Compound:7945887|FD-Score:4.53|P-value:5.08E-5 ID:SGTC_2326|Compound:6164455|FD-Score:4.04|P-value:2.74E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.15|P-value:1.89E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-4.42|P-value:5.05E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.64|P-value:6.72E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.58|P-value:7.90E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.69|P-value:7.96E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.50|P-value:3.81E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.27|P-value:1.28E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-4.13|P-value:1.38E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.35|P-value:1.35E-6 ID:SGTC_2940|Compound:9060638|FD-Score:4.08|P-value:2.39E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.92|P-value:3.97E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-4.84|P-value:1.06E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-3.77|P-value:4.44E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.13|P-value:1.38E-4 ID:SGTC_3275|Compound:9138069|FD-Score:4.23|P-value:1.44E-4 ID:SGTC_3310|Compound:9130229|FD-Score:4.38|P-value:8.69E-5

Top fitness defect scores for YKL068W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_134 0269-0018 22.70 6.9 µM 1.24E-86 3 8.44E-115
2 SGTC_236 1509-0011 18.40 5.3 µM 3.99E-57 65 1.45E-75
3 SGTC_275 trichlorophene 14.20 5.7 µM 5.18E-35 mitochondrial stress 11 3.75E-46
4 SGTC_386 1509-0011 14.10 3.1 µM 2.13E-34 24 2.46E-45
5 SGTC_1635 st007035 12.30 42.4 µM 1.61E-26 59 7.45E-35
6 SGTC_1921 5740136 8.26 50.0 µM 5.47E-13 TRP & mitochondrial translation 2 7.45E-17
7 SGTC_119 0121-0043 7.80 24.8 µM 9.05E-12 mitochondrial stress 11 3.11E-15
8 SGTC_10 0279-0212 7.39 42.6 µM 1.00E-10 TRP & mitochondrial translation 10 7.62E-14
9 SGTC_70 0141-0289 6.89 43.3 µM 1.48E-9 mitochondrial stress 54 2.72E-12
10 SGTC_596 1155-0152 6.30 116.0 µM 3.02E-8 TRP & mitochondrial translation 8 1.50E-10
11 SGTC_1372 2752-0194 6.15 270.0 µM 6.09E-8 3 3.82E-10
12 SGTC_614 0462-0418 5.98 107.0 µM 1.38E-7 5 1.14E-9
13 SGTC_1722 st034304 5.80 3.6 µM 3.04E-7 mitochondrial processes 8 3.24E-9
14 SGTC_1742 st038235 5.64 28.9 µM 6.20E-7 mitochondrial stress 56 8.33E-9
15 SGTC_173 1273-0061 5.49 2.7 µM 1.19E-6 mitochondrial stress 124 1.98E-8
16 SGTC_1371 2421-0008 5.17 32.7 µM 4.45E-6 mitochondrial processes 10 1.14E-7
17 SGTC_1883 5-benzylidenerhodanine 5.11 20.0 µM 5.83E-6 TRP & mitochondrial translation 28 1.63E-7
18 SGTC_908 3448-7491 5.08 47.7 µM 6.46E-6 mitochondrial stress 76 1.87E-7
19 SGTC_761 k216-0224 4.95 480.0 µM 1.07E-5 8 3.65E-7
20 SGTC_543 3844-1095 4.86 191.0 µM 1.51E-5 ERG2 32 5.75E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.555 4.77E-270 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.551 9.04E-266 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.550 1.05E-264 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.540 6.37E-253 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.538 9.91E-252 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.534 5.40E-247 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.531 1.25E-243 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.528 1.26E-240 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.521 1.62E-232 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.517 6.33E-229 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.516 3.02E-228 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.516 1.21E-227 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.513 1.05E-224 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.510 3.71E-222 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.509 1.99E-220 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes