HIPHOP chemogenomics database
YKL069W 
Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YKL069W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.127 | 1.68E-13 | YMR147W_p | YMR147W_p | hom | Putative protein of unknown function |
| 0.095 | 3.38E-8 | YBL050W | SEC17 | het | Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP |
| 0.086 | 6.36E-7 | YBR031W | RPL4A | hom | Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication |
| 0.085 | 8.33E-7 | YJL028W | YJL028W | hom | Protein of unknown function; may interact with ribosomes, based on co-purification experiments |
| 0.085 | 9.13E-7 | YMR317W_p | YMR317W_p | hom | Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene |
| 0.083 | 1.32E-6 | YOL025W | LAG2 | hom | Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1 |
| 0.083 | 1.39E-6 | YGR265W_d | YGR265W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase |
| 0.083 | 1.69E-6 | YKR033C_d | YKR033C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 |
| 0.082 | 2.09E-6 | YAL038W | CDC19 | het | Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication |
| 0.082 | 2.05E-6 | YML101C-A_d | YML101C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.081 | 2.70E-6 | YNL034W_p | YNL034W_p | hom | Putative protein of unknown function; YNL034W is not an essential gene |
| 0.080 | 3.96E-6 | YOR366W_d | YOR366W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C |
| 0.077 | 8.08E-6 | YLR138W | NHA1 | hom | Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH |
| 0.077 | 8.21E-6 | YLR064W | PER33 | hom | Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress |
| 0.076 | 1.10E-5 | YHR204W | MNL1 | hom | Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation |