YKL072W / STB6

Protein that binds Sin3p in a two-hybrid assay

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL072W / STB6

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.72|P-value:1.73E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.87|P-value:4.61E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:3.80|P-value:6.59E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:4.91|P-value:1.02E-8 ID:SGTC_650|Compound:1328-0195|FD-Score:3.31|P-value:7.27E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:2.74|P-value:7.96E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.38|P-value:9.12E-10 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.03|P-value:3.54E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:2.68|P-value:9.77E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.16|P-value:2.33E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.54|P-value:2.47E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:4.48|P-value:1.49E-7 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.71|P-value:8.74E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.91|P-value:6.36E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.89|P-value:4.36E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:2.99|P-value:2.86E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.09|P-value:1.91E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.35|P-value:5.82E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.05|P-value:3.55E-4 ID:SGTC_1935|Compound:st074532|FD-Score:2.97|P-value:3.15E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.89|P-value:7.33E-6 ID:SGTC_2101|Compound:5377231|FD-Score:2.77|P-value:7.05E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.28|P-value:4.90E-7 ID:SGTC_2396|Compound:5342950|FD-Score:3.25|P-value:9.44E-5 ID:SGTC_2398|Compound:5228213|FD-Score:2.71|P-value:8.97E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:2.98|P-value:3.03E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.55|P-value:3.95E-5 ID:SGTC_2863|Compound:9028737|FD-Score:2.80|P-value:6.24E-4 ID:SGTC_3113|Compound:9123498|FD-Score:-2.95|P-value:5.33E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.11|P-value:1.70E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.44|P-value:3.97E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.72|P-value:1.73E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.87|P-value:4.61E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:3.80|P-value:6.59E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:4.91|P-value:1.02E-8 ID:SGTC_650|Compound:1328-0195|FD-Score:3.31|P-value:7.27E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:2.74|P-value:7.96E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.38|P-value:9.12E-10 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.03|P-value:3.54E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:2.68|P-value:9.77E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.16|P-value:2.33E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.54|P-value:2.47E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:4.48|P-value:1.49E-7 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.71|P-value:8.74E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.91|P-value:6.36E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.89|P-value:4.36E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:2.99|P-value:2.86E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.09|P-value:1.91E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.35|P-value:5.82E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.05|P-value:3.55E-4 ID:SGTC_1935|Compound:st074532|FD-Score:2.97|P-value:3.15E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.89|P-value:7.33E-6 ID:SGTC_2101|Compound:5377231|FD-Score:2.77|P-value:7.05E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.28|P-value:4.90E-7 ID:SGTC_2396|Compound:5342950|FD-Score:3.25|P-value:9.44E-5 ID:SGTC_2398|Compound:5228213|FD-Score:2.71|P-value:8.97E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:2.98|P-value:3.03E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.55|P-value:3.95E-5 ID:SGTC_2863|Compound:9028737|FD-Score:2.80|P-value:6.24E-4 ID:SGTC_3113|Compound:9123498|FD-Score:-2.95|P-value:5.33E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.11|P-value:1.70E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.44|P-value:3.97E-5

Top fitness defect scores for YKL072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_133 0724-0033 4.91 378.9 µM 1.02E-8 11 4.59E-7
2 SGTC_1169 aniline yellow 4.48 25.8 µM 1.49E-7 4 3.75E-6
3 SGTC_2318 6029776 4.28 164.0 µM 4.90E-7 16 9.50E-6
4 SGTC_130 0136-0219 3.87 337.7 µM 4.61E-6 23 5.48E-5
5 SGTC_132 0417-1715 3.80 25.8 µM 6.59E-6 RPP1 & pyrimidine depletion 25 7.25E-5
6 SGTC_986 1493-0483 3.54 84.0 µM 2.47E-5 22 2.04E-4
7 SGTC_3318 9139014 3.44 38.6 µM 3.97E-5 27 2.96E-4
8 SGTC_1500 4488-1866 3.35 171.0 µM 5.82E-5 RPP1 & pyrimidine depletion 39 3.98E-4
9 SGTC_650 1328-0195 3.31 38.0 µM 7.27E-5 38 4.74E-4
10 SGTC_2396 5342950 3.25 42.8 µM 9.44E-5 RSC complex & mRNA processing 79 5.82E-4
11 SGTC_3314 9135860 3.11 59.4 µM 1.70E-4 50 9.22E-4
12 SGTC_1399 3562-5772 3.09 25.0 µM 1.91E-4 RPP1 & pyrimidine depletion 33 0.00101
13 SGTC_1382 3002-2117 2.99 298.0 µM 2.86E-4 45 0.00139
14 SGTC_2754 granisetron 2.98 64.0 µM 3.03E-4 93 0.00145
15 SGTC_1935 st074532 2.97 41.6 µM 3.15E-4 90 0.00150
16 SGTC_1343 1487-0095 2.89 224.0 µM 4.36E-4 39 0.00193
17 SGTC_2863 9028737 2.80 58.4 µM 6.24E-4 31 0.00256
18 SGTC_2101 5377231 2.77 179.2 µM 7.05E-4 48 0.00281
19 SGTC_700 3453-2283 2.74 142.0 µM 7.96E-4 amide catabolism 104 0.00309
20 SGTC_1230 0170-0365 2.71 3.8 µM 8.74E-4 endomembrane recycling 192 0.00333

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 8.44E-33 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.202 3.61E-32 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.193 1.73E-29 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.188 3.80E-28 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.186 1.21E-27 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.154 3.18E-19 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.151 1.52E-18 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.147 1.27E-17 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.145 3.28E-17 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.145 3.56E-17 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.142 1.44E-16 YER056C FCY2 hom Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress
0.141 1.93E-16 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.141 2.29E-16 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.139 6.28E-16 YML116W-A_d YML116W-A_d hom Putative protein of unknown function
0.137 1.87E-15 YML131W YML131W hom Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress