YKL076C_d / PSY1

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL076C / PSY1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.81|P-value:8.21E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:19.10|P-value:1.17E-80 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.82|P-value:7.25E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:3.13|P-value:9.78E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.92|P-value:2.12E-15 ID:SGTC_268|Compound:camptothecin|FD-Score:5.28|P-value:8.40E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:8.07|P-value:6.38E-16 ID:SGTC_351|Compound:caspofungin|FD-Score:3.59|P-value:1.90E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.90|P-value:2.58E-9 ID:SGTC_486|Compound:niguldipine|FD-Score:3.14|P-value:9.65E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.07|P-value:2.80E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.42|P-value:5.96E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.57|P-value:1.91E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:8.69|P-value:3.47E-18 ID:SGTC_825|Compound:1988-2224|FD-Score:3.63|P-value:1.64E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.23|P-value:6.93E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:8.80|P-value:1.41E-18 ID:SGTC_928|Compound:2764-0428|FD-Score:3.39|P-value:3.97E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.34|P-value:4.86E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:8.64|P-value:5.35E-18 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.44|P-value:5.56E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.89|P-value:5.86E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.65|P-value:1.50E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.60|P-value:2.64E-6 ID:SGTC_1621|Compound:st003705|FD-Score:3.20|P-value:7.76E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.19|P-value:7.91E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.48|P-value:2.88E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.32|P-value:6.75E-8 ID:SGTC_1742|Compound:st038235|FD-Score:-4.21|P-value:1.37E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.49|P-value:2.83E-4 ID:SGTC_1745|Compound:st081495|FD-Score:10.80|P-value:4.04E-27 ID:SGTC_1792|Compound:st045773|FD-Score:3.67|P-value:1.40E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.22|P-value:7.27E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.22|P-value:6.61E-4 ID:SGTC_2006|Compound:4011487|FD-Score:5.32|P-value:7.03E-8 ID:SGTC_2010|Compound:4012422|FD-Score:3.13|P-value:9.84E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.15|P-value:9.28E-4 ID:SGTC_2111|Compound:5486399|FD-Score:5.47|P-value:3.00E-8 ID:SGTC_2192|Compound:5915882|FD-Score:5.55|P-value:1.89E-8 ID:SGTC_2272|Compound:7805186|FD-Score:3.66|P-value:1.49E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.13|P-value:1.90E-7 ID:SGTC_2461|Compound:5755302|FD-Score:-3.31|P-value:4.87E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.33|P-value:4.91E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.94|P-value:4.89E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:9.27|P-value:2.01E-20 ID:SGTC_2587|Compound:piperic acid|FD-Score:5.30|P-value:7.71E-8 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.29|P-value:5.63E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.63|P-value:1.63E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-4.51|P-value:3.64E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.35|P-value:4.25E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.14|P-value:9.60E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.29|P-value:5.22E-4 ID:SGTC_2895|Compound:9054447|FD-Score:3.17|P-value:8.54E-4 ID:SGTC_2912|Compound:7964298|FD-Score:9.21|P-value:3.48E-20 ID:SGTC_2916|Compound:7875993|FD-Score:3.27|P-value:6.18E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-4.01|P-value:3.24E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.74|P-value:1.37E-6 ID:SGTC_3136|Compound:9095672|FD-Score:3.55|P-value:2.26E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.29|P-value:1.08E-5 ID:SGTC_3178|Compound:9107506|FD-Score:-3.19|P-value:7.31E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.44|P-value:5.59E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.14|P-value:1.75E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:3.81|P-value:8.21E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:19.10|P-value:1.17E-80 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.82|P-value:7.25E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:3.13|P-value:9.78E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.92|P-value:2.12E-15 ID:SGTC_268|Compound:camptothecin|FD-Score:5.28|P-value:8.40E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:8.07|P-value:6.38E-16 ID:SGTC_351|Compound:caspofungin|FD-Score:3.59|P-value:1.90E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.90|P-value:2.58E-9 ID:SGTC_486|Compound:niguldipine|FD-Score:3.14|P-value:9.65E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.07|P-value:2.80E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.42|P-value:5.96E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.57|P-value:1.91E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:8.69|P-value:3.47E-18 ID:SGTC_825|Compound:1988-2224|FD-Score:3.63|P-value:1.64E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.23|P-value:6.93E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:8.80|P-value:1.41E-18 ID:SGTC_928|Compound:2764-0428|FD-Score:3.39|P-value:3.97E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.34|P-value:4.86E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:8.64|P-value:5.35E-18 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.44|P-value:5.56E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.89|P-value:5.86E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.65|P-value:1.50E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.60|P-value:2.64E-6 ID:SGTC_1621|Compound:st003705|FD-Score:3.20|P-value:7.76E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.19|P-value:7.91E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.48|P-value:2.88E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.32|P-value:6.75E-8 ID:SGTC_1742|Compound:st038235|FD-Score:-4.21|P-value:1.37E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.49|P-value:2.83E-4 ID:SGTC_1745|Compound:st081495|FD-Score:10.80|P-value:4.04E-27 ID:SGTC_1792|Compound:st045773|FD-Score:3.67|P-value:1.40E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.22|P-value:7.27E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.22|P-value:6.61E-4 ID:SGTC_2006|Compound:4011487|FD-Score:5.32|P-value:7.03E-8 ID:SGTC_2010|Compound:4012422|FD-Score:3.13|P-value:9.84E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.15|P-value:9.28E-4 ID:SGTC_2111|Compound:5486399|FD-Score:5.47|P-value:3.00E-8 ID:SGTC_2192|Compound:5915882|FD-Score:5.55|P-value:1.89E-8 ID:SGTC_2272|Compound:7805186|FD-Score:3.66|P-value:1.49E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.13|P-value:1.90E-7 ID:SGTC_2461|Compound:5755302|FD-Score:-3.31|P-value:4.87E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.33|P-value:4.91E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.94|P-value:4.89E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:9.27|P-value:2.01E-20 ID:SGTC_2587|Compound:piperic acid|FD-Score:5.30|P-value:7.71E-8 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.29|P-value:5.63E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.63|P-value:1.63E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-4.51|P-value:3.64E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.35|P-value:4.25E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.14|P-value:9.60E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.29|P-value:5.22E-4 ID:SGTC_2895|Compound:9054447|FD-Score:3.17|P-value:8.54E-4 ID:SGTC_2912|Compound:7964298|FD-Score:9.21|P-value:3.48E-20 ID:SGTC_2916|Compound:7875993|FD-Score:3.27|P-value:6.18E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-4.01|P-value:3.24E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.74|P-value:1.37E-6 ID:SGTC_3136|Compound:9095672|FD-Score:3.55|P-value:2.26E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.29|P-value:1.08E-5 ID:SGTC_3178|Compound:9107506|FD-Score:-3.19|P-value:7.31E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.44|P-value:5.59E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.14|P-value:1.75E-7

Top fitness defect scores for YKL076C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 19.10 9.0 µM 1.17E-80 cell wall 14 6.24E-82
2 SGTC_1745 st081495 10.80 74.0 µM 4.04E-27 RNA processing & uracil transport 6 1.49E-27
3 SGTC_2584 androsterone 9.27 48.7 µM 2.01E-20 cell wall 19 9.47E-21
4 SGTC_2912 7964298 9.21 10.9 µM 3.48E-20 cell wall 20 1.65E-20
5 SGTC_863 0466-0191 8.80 129.0 µM 1.41E-18 cell wall 15 7.12E-19
6 SGTC_666 0272-0154 8.69 136.0 µM 3.47E-18 cell wall 7 1.78E-18
7 SGTC_1213 1315-0166 8.64 115.0 µM 5.35E-18 5 2.76E-18
8 SGTC_304 1310-0298 8.07 97.0 µM 6.38E-16 cell wall 6 3.55E-16
9 SGTC_138 0850-0259 7.92 40.9 µM 2.12E-15 cell wall 63 1.20E-15
10 SGTC_467 ro 31-8220 5.90 72.8 µM 2.58E-9 calcium & mitochondrial duress 31 1.84E-9
11 SGTC_2192 5915882 5.55 198.5 µM 1.89E-8 RNA processing & uracil transport 16 1.39E-8
12 SGTC_2111 5486399 5.47 200.0 µM 3.00E-8 9 2.23E-8
13 SGTC_1712 st032288 5.32 53.4 µM 6.75E-8 calcium & mitochondrial duress 101 5.09E-8
14 SGTC_2006 4011487 5.32 200.0 µM 7.03E-8 endomembrane recycling 56 5.31E-8
15 SGTC_2587 piperic acid 5.30 92.2 µM 7.71E-8 3 5.83E-8
16 SGTC_268 camptothecin 5.28 39.6 µM 8.40E-8 DNA damage response 41 6.36E-8
17 SGTC_3311 9131146 5.14 2.9 µM 1.75E-7 cell wall 81 1.34E-7
18 SGTC_2405 ticlatone 5.13 3.5 µM 1.90E-7 38 1.45E-7
19 SGTC_2970 9090938 4.74 41.9 µM 1.37E-6 RNA processing & uracil transport 17 1.09E-6
20 SGTC_1597 7-benzyloxygramine 4.60 47.5 µM 2.64E-6 calcium & mitochondrial duress 81 2.12E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.503 4.97E-215 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.469 1.59E-183 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.467 1.66E-181 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.451 2.71E-167 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.449 8.63E-166 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.439 2.16E-158 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.429 5.77E-150 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.417 1.20E-141 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.415 1.06E-139 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.414 1.94E-139 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.403 1.86E-131 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.390 5.35E-122 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.377 1.11E-113 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.367 2.28E-107 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.365 2.20E-106 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases