HIPHOP chemogenomics database
YKL078W / DHR2 
Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YKL078W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.114 | 3.71E-11 | YJL152W_d | YJL152W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.108 | 3.05E-10 | YHR152W | SPO12 | hom | Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis |
| 0.102 | 3.43E-9 | YLR092W | SUL2 | hom | High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates |
| 0.096 | 2.46E-8 | YHR065C | RRP3 | het | Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity |
| 0.095 | 3.41E-8 | YGL122C | NAB2 | het | Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress |
| 0.095 | 3.56E-8 | YMR117C | SPC24 | het | Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering |
| 0.084 | 1.08E-6 | YBR186W | PCH2 | hom | Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation |
| 0.084 | 1.19E-6 | YOR378W_p | YOR378W_p | hom | Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene |
| 0.081 | 2.92E-6 | YPL136W_d | YPL136W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C |
| 0.080 | 3.31E-6 | YOR136W | IDH2 | hom | Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated |
| 0.080 | 3.41E-6 | YOR123C | LEO1 | hom | Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay |
| 0.079 | 4.86E-6 | YDR247W | VHS1 | hom | Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p |
| 0.076 | 9.34E-6 | YOR267C | HRK1 | hom | Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress |
| 0.075 | 1.27E-5 | YPL110C | GDE1 | hom | Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes |
| 0.075 | 1.45E-5 | YNL092W_p | YNL092W_p | hom | Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene |