YKL078W / DHR2

Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL078W / DHR2

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-4.33|P-value:3.53E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:3.06|P-value:7.47E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.63|P-value:8.53E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.32|P-value:2.85E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:8.98|P-value:5.95E-21 ID:SGTC_519|Compound:k048-0011|FD-Score:5.14|P-value:4.79E-8 ID:SGTC_656|Compound:4090-1979|FD-Score:3.17|P-value:5.06E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:4.94|P-value:1.49E-7 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.07|P-value:7.21E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.24|P-value:3.98E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.52|P-value:1.32E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.20|P-value:4.58E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.06|P-value:7.65E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.18|P-value:4.83E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:4.67|P-value:6.54E-7 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.38|P-value:2.26E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.71|P-value:5.95E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.33|P-value:1.65E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:-4.20|P-value:6.66E-6 ID:SGTC_1060|Compound:3448-7350|FD-Score:6.83|P-value:7.15E-13 ID:SGTC_1061|Compound:3448-9325|FD-Score:9.27|P-value:3.46E-22 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.91|P-value:1.79E-7 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.10|P-value:1.05E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.17|P-value:5.07E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.32|P-value:2.86E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.05|P-value:1.35E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.75|P-value:5.10E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-2.99|P-value:9.71E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.90|P-value:2.63E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.34|P-value:2.63E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.59|P-value:9.96E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.74|P-value:5.30E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.11|P-value:6.20E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.37|P-value:2.36E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.40|P-value:2.08E-4 ID:SGTC_2159|Compound:5658611|FD-Score:5.15|P-value:4.55E-8 ID:SGTC_2189|Compound:6047310|FD-Score:-3.08|P-value:6.97E-4 ID:SGTC_2205|Compound:7238770|FD-Score:-3.30|P-value:3.07E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.45|P-value:1.74E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.39|P-value:2.22E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.94|P-value:1.55E-7 ID:SGTC_2340|Compound:7987427|FD-Score:3.56|P-value:1.12E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.05|P-value:7.91E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.62|P-value:8.58E-5 ID:SGTC_2430|Compound:5571206|FD-Score:2.99|P-value:9.52E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.33|P-value:2.83E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.05|P-value:7.71E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.17|P-value:5.10E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.19|P-value:4.78E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.99|P-value:9.81E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.08|P-value:7.04E-4 ID:SGTC_2894|Compound:9048625|FD-Score:4.61|P-value:8.76E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-3.12|P-value:6.06E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.56|P-value:1.12E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.41|P-value:2.05E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-2.98|P-value:9.85E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.58|P-value:9.98E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.23|P-value:3.99E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.78|P-value:4.47E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.83|P-value:3.57E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.21|P-value:4.26E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.45|P-value:1.76E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.71|P-value:6.02E-5 ID:SGTC_3154|Compound:9100113|FD-Score:5.22|P-value:3.08E-8 ID:SGTC_3158|Compound:9100007|FD-Score:4.18|P-value:7.38E-6 ID:SGTC_3207|Compound:9114163|FD-Score:3.10|P-value:6.43E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.84|P-value:3.46E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.66|P-value:7.54E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.33|P-value:3.53E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:3.06|P-value:7.47E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.63|P-value:8.53E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.32|P-value:2.85E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:8.98|P-value:5.95E-21 ID:SGTC_519|Compound:k048-0011|FD-Score:5.14|P-value:4.79E-8 ID:SGTC_656|Compound:4090-1979|FD-Score:3.17|P-value:5.06E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:4.94|P-value:1.49E-7 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.07|P-value:7.21E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.24|P-value:3.98E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.52|P-value:1.32E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.20|P-value:4.58E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.06|P-value:7.65E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.18|P-value:4.83E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:4.67|P-value:6.54E-7 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.38|P-value:2.26E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.71|P-value:5.95E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.33|P-value:1.65E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:-4.20|P-value:6.66E-6 ID:SGTC_1060|Compound:3448-7350|FD-Score:6.83|P-value:7.15E-13 ID:SGTC_1061|Compound:3448-9325|FD-Score:9.27|P-value:3.46E-22 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.91|P-value:1.79E-7 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.10|P-value:1.05E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.17|P-value:5.07E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.32|P-value:2.86E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.05|P-value:1.35E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.75|P-value:5.10E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-2.99|P-value:9.71E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.90|P-value:2.63E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.34|P-value:2.63E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.59|P-value:9.96E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.74|P-value:5.30E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.11|P-value:6.20E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.37|P-value:2.36E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.40|P-value:2.08E-4 ID:SGTC_2159|Compound:5658611|FD-Score:5.15|P-value:4.55E-8 ID:SGTC_2189|Compound:6047310|FD-Score:-3.08|P-value:6.97E-4 ID:SGTC_2205|Compound:7238770|FD-Score:-3.30|P-value:3.07E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.45|P-value:1.74E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.39|P-value:2.22E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.94|P-value:1.55E-7 ID:SGTC_2340|Compound:7987427|FD-Score:3.56|P-value:1.12E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.05|P-value:7.91E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.62|P-value:8.58E-5 ID:SGTC_2430|Compound:5571206|FD-Score:2.99|P-value:9.52E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.33|P-value:2.83E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.05|P-value:7.71E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.17|P-value:5.10E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.19|P-value:4.78E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.99|P-value:9.81E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.08|P-value:7.04E-4 ID:SGTC_2894|Compound:9048625|FD-Score:4.61|P-value:8.76E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-3.12|P-value:6.06E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.56|P-value:1.12E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.41|P-value:2.05E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-2.98|P-value:9.85E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.58|P-value:9.98E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.23|P-value:3.99E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.78|P-value:4.47E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.83|P-value:3.57E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.21|P-value:4.26E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.45|P-value:1.76E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.71|P-value:6.02E-5 ID:SGTC_3154|Compound:9100113|FD-Score:5.22|P-value:3.08E-8 ID:SGTC_3158|Compound:9100007|FD-Score:4.18|P-value:7.38E-6 ID:SGTC_3207|Compound:9114163|FD-Score:3.10|P-value:6.43E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.84|P-value:3.46E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.66|P-value:7.54E-5

Top fitness defect scores for YKL078W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1061 3448-9325 9.27 110.0 µM 3.46E-22 1 9.26E-21 2.53
2 SGTC_425 3825-7017 8.98 13.1 µM 5.95E-21 2 1.31E-19 2.36
3 SGTC_1060 3448-7350 6.83 82.0 µM 7.15E-13 Golgi 6 4.30E-12 0.62
4 SGTC_1045 1348-1485 5.33 165.0 µM 1.65E-8 2 4.96E-8 1.05
5 SGTC_3154 9100113 5.22 49.5 µM 3.08E-8 3 8.89E-8 0.28
6 SGTC_2159 5658611 5.15 73.8 µM 4.55E-8 2 1.28E-7 0.06
7 SGTC_519 k048-0011 5.14 62.8 µM 4.79E-8 3 1.34E-7 0.50
8 SGTC_668 1682-0499 4.94 62.6 µM 1.49E-7 2 3.86E-7 0.61
9 SGTC_2332 7982454 4.94 138.9 µM 1.55E-7 4 4.00E-7 0.17
10 SGTC_997 3996-0078 4.67 137.0 µM 6.54E-7 4 1.53E-6 0.40
11 SGTC_2894 9048625 4.61 32.5 µM 8.76E-7 5 2.01E-6 0.27
12 SGTC_3158 9100007 4.18 49.5 µM 7.38E-6 4 1.47E-5 0.22
13 SGTC_1222 0366-0074 4.10 1.2 µM 1.05E-5 TSC3-RPN4 4 2.03E-5 0.35
14 SGTC_1378 2093-0007 4.05 380.0 nM 1.35E-5 4 2.58E-5 0.07
15 SGTC_2002 4023503 3.90 131.0 µM 2.63E-5 mitochondrial processes 9 4.80E-5 0.09
16 SGTC_3309 9129340 3.84 25.8 µM 3.46E-5 3 6.20E-5 0.52
17 SGTC_3104 9120930 3.83 49.5 µM 3.57E-5 3 6.39E-5 0.18
18 SGTC_2989 9073649 3.78 71.4 µM 4.47E-5 11 7.89E-5 0.03
19 SGTC_1547 harmine 3.75 94.2 µM 5.10E-5 ergosterol biosynthesis 17 8.93E-5 0.10
20 SGTC_2024 5144227 3.74 134.0 µM 5.30E-5 6 9.24E-5 0.17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.71E-11 YJL152W_d YJL152W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 3.05E-10 YHR152W SPO12 hom Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
0.102 3.43E-9 YLR092W SUL2 hom High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.096 2.46E-8 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.095 3.41E-8 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.095 3.56E-8 YMR117C SPC24 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.084 1.08E-6 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.084 1.19E-6 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
0.081 2.92E-6 YPL136W_d YPL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C
0.080 3.31E-6 YOR136W IDH2 hom Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
0.080 3.41E-6 YOR123C LEO1 hom Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
0.079 4.86E-6 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.076 9.34E-6 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.075 1.27E-5 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.075 1.45E-5 YNL092W_p YNL092W_p hom Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene