HIPHOP chemogenomics database
YKL080W / VMA5 
Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKL080W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.156 | 9.51E-20 | YDR518W | EUG1 | hom | Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER |
| 0.154 | 3.16E-19 | YGL107C | RMD9 | hom | Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes |
| 0.151 | 1.23E-18 | YBL080C | PET112 | hom | Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog |
| 0.143 | 9.40E-17 | YDR231C | COX20 | hom | Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase |
| 0.142 | 1.37E-16 | YIL070C | MAM33 | hom | Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R |
| 0.141 | 1.80E-16 | YML129C | COX14 | hom | Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes |
| 0.139 | 6.44E-16 | YPR088C | SRP54 | het | Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain |
| 0.137 | 1.77E-15 | YJL023C | PET130 | hom | Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.136 | 2.52E-15 | YDR377W | ATP17 | hom | Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis |
| 0.134 | 6.33E-15 | YJL046W | AIM22 | hom | Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss |
| 0.132 | 1.35E-14 | YNL252C | MRPL17 | hom | Mitochondrial ribosomal protein of the large subunit |
| 0.132 | 1.59E-14 | YOR200W_d | YOR200W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c |
| 0.131 | 2.09E-14 | YHL004W | MRP4 | hom | Mitochondrial ribosomal protein of the small subunit |
| 0.131 | 2.26E-14 | YDR079W | PET100 | hom | Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme |
| 0.130 | 3.58E-14 | YKL068W-A_p | YKL068W-A_p | hom | Putative protein of unknown function; identified by homology to Ashbya gossypii |