YKL082C / RRP14

Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL082C / RRP14

Click on Significant Values for Screen Details ID:SGTC_151|Compound:3013-0144|FD-Score:3.14|P-value:2.24E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.52|P-value:4.23E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.16|P-value:2.51E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-2.87|P-value:7.92E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.17|P-value:2.34E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.88|P-value:7.56E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:2.88|P-value:6.42E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.11|P-value:2.59E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.04|P-value:3.42E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.15|P-value:2.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.74|P-value:8.05E-8 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.15|P-value:2.12E-4 ID:SGTC_1521|Compound:st012942|FD-Score:2.77|P-value:9.80E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:2.95|P-value:4.96E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.49|P-value:4.97E-5 ID:SGTC_1867|Compound:st057372|FD-Score:3.99|P-value:4.19E-6 ID:SGTC_1882|Compound:5615643|FD-Score:3.11|P-value:2.54E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.99|P-value:5.42E-6 ID:SGTC_2009|Compound:4012297|FD-Score:-3.44|P-value:7.48E-5 ID:SGTC_2016|Compound:5121758|FD-Score:-5.46|P-value:8.03E-10 ID:SGTC_2017|Compound:5132927|FD-Score:-3.52|P-value:5.06E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.08|P-value:3.38E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-2.89|P-value:7.19E-4 ID:SGTC_2175|Compound:5807670|FD-Score:2.91|P-value:5.75E-4 ID:SGTC_2196|Compound:6573537|FD-Score:4.15|P-value:1.84E-6 ID:SGTC_2201|Compound:6605497|FD-Score:3.11|P-value:2.59E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.13|P-value:2.06E-6 ID:SGTC_2322|Compound:7413319|FD-Score:4.07|P-value:2.77E-6 ID:SGTC_2335|Compound:9018011|FD-Score:3.15|P-value:2.12E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.87|P-value:6.68E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.11|P-value:2.58E-4 ID:SGTC_2443|Compound:5493264|FD-Score:5.20|P-value:3.51E-9 ID:SGTC_2450|Compound:5739737|FD-Score:-2.91|P-value:6.77E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.12|P-value:2.89E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.78|P-value:9.27E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.34|P-value:9.68E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.22|P-value:1.58E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.60|P-value:2.86E-5 ID:SGTC_2933|Compound:9026794|FD-Score:5.37|P-value:1.08E-9 ID:SGTC_2935|Compound:9038016|FD-Score:3.07|P-value:3.00E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-2.96|P-value:5.51E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.06|P-value:3.08E-4 ID:SGTC_3017|Compound:9080681|FD-Score:2.95|P-value:4.81E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.48|P-value:6.19E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.65|P-value:2.32E-5 ID:SGTC_3219|Compound:9131112|FD-Score:2.87|P-value:6.57E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.78|P-value:1.25E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.14|P-value:2.24E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.52|P-value:4.23E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.16|P-value:2.51E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-2.87|P-value:7.92E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.17|P-value:2.34E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.88|P-value:7.56E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:2.88|P-value:6.42E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.11|P-value:2.59E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.04|P-value:3.42E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.15|P-value:2.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.74|P-value:8.05E-8 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.15|P-value:2.12E-4 ID:SGTC_1521|Compound:st012942|FD-Score:2.77|P-value:9.80E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:2.95|P-value:4.96E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.49|P-value:4.97E-5 ID:SGTC_1867|Compound:st057372|FD-Score:3.99|P-value:4.19E-6 ID:SGTC_1882|Compound:5615643|FD-Score:3.11|P-value:2.54E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.99|P-value:5.42E-6 ID:SGTC_2009|Compound:4012297|FD-Score:-3.44|P-value:7.48E-5 ID:SGTC_2016|Compound:5121758|FD-Score:-5.46|P-value:8.03E-10 ID:SGTC_2017|Compound:5132927|FD-Score:-3.52|P-value:5.06E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.08|P-value:3.38E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-2.89|P-value:7.19E-4 ID:SGTC_2175|Compound:5807670|FD-Score:2.91|P-value:5.75E-4 ID:SGTC_2196|Compound:6573537|FD-Score:4.15|P-value:1.84E-6 ID:SGTC_2201|Compound:6605497|FD-Score:3.11|P-value:2.59E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.13|P-value:2.06E-6 ID:SGTC_2322|Compound:7413319|FD-Score:4.07|P-value:2.77E-6 ID:SGTC_2335|Compound:9018011|FD-Score:3.15|P-value:2.12E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.87|P-value:6.68E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.11|P-value:2.58E-4 ID:SGTC_2443|Compound:5493264|FD-Score:5.20|P-value:3.51E-9 ID:SGTC_2450|Compound:5739737|FD-Score:-2.91|P-value:6.77E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.12|P-value:2.89E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.78|P-value:9.27E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.34|P-value:9.68E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.22|P-value:1.58E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.60|P-value:2.86E-5 ID:SGTC_2933|Compound:9026794|FD-Score:5.37|P-value:1.08E-9 ID:SGTC_2935|Compound:9038016|FD-Score:3.07|P-value:3.00E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-2.96|P-value:5.51E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.06|P-value:3.08E-4 ID:SGTC_3017|Compound:9080681|FD-Score:2.95|P-value:4.81E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.48|P-value:6.19E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.65|P-value:2.32E-5 ID:SGTC_3219|Compound:9131112|FD-Score:2.87|P-value:6.57E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.78|P-value:1.25E-5

Top fitness defect scores for YKL082C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2933 9026794 5.37 32.5 µM 1.08E-9 2 3.91E-8 0.77
2 SGTC_2443 5493264 5.20 126.7 µM 3.51E-9 1 1.02E-7 0.39
3 SGTC_2196 6573537 4.15 42.7 µM 1.84E-6 copper-dependent oxidative stress 1 1.66E-5 0.44
4 SGTC_2309 7664088 4.13 163.9 µM 2.06E-6 8 1.83E-5 0.03
5 SGTC_2322 7413319 4.07 38.2 µM 2.77E-6 ERAD & cell cycle 23 2.32E-5 0.03
6 SGTC_1867 st057372 3.99 64.0 µM 4.19E-6 2 3.26E-5 0.38
7 SGTC_3314 9135860 3.78 59.4 µM 1.25E-5 2 7.96E-5 0.08
8 SGTC_3215 9129942 3.65 49.5 µM 2.32E-5 6 1.32E-4 0.21
9 SGTC_2929 9013348 3.60 24.6 µM 2.86E-5 6 1.56E-4 0.49
10 SGTC_156 3474-0145 3.52 5.6 µM 4.23E-5 endomembrane recycling 10 2.15E-4 0.04
11 SGTC_1744 st037937 3.49 38.9 µM 4.97E-5 9 2.46E-4 0.16
12 SGTC_2794 7785382 3.34 27.3 µM 9.68E-5 21 4.23E-4 0.01
13 SGTC_2802 7925815 3.22 54.5 µM 1.58E-4 16 6.33E-4 0.06
14 SGTC_2335 9018011 3.15 154.2 µM 2.12E-4 19 8.03E-4 0.07
15 SGTC_1418 3966-3099 3.15 2.4 µM 2.12E-4 9 8.05E-4 8.24E-4
16 SGTC_1083 didemethylchlorpromazine sulfoxide 3.15 707.4 nM 2.18E-4 redox potentiating 36 8.23E-4 0.07
17 SGTC_151 3013-0144 3.14 2.3 µM 2.24E-4 iron homeostasis 20 8.42E-4 0.01
18 SGTC_1882 5615643 3.11 20.0 µM 2.54E-4 TRP & mitochondrial translation 13 9.31E-4 0.06
19 SGTC_2363 9053361 3.11 176.0 µM 2.58E-4 Golgi 21 9.43E-4 0.03
20 SGTC_807 1315-0151 3.11 48.0 µM 2.59E-4 22 9.46E-4 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 2.84E-21 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.150 2.17E-18 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.149 3.35E-18 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.145 3.94E-17 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.135 4.50E-15 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.123 8.10E-13 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.120 2.89E-12 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.120 3.60E-12 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.118 7.16E-12 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 7.71E-12 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.116 1.82E-11 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.115 2.19E-11 YOR016C ERP4 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.115 2.24E-11 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.114 3.64E-11 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.113 6.33E-11 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis