YKL086W / SRX1

Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL086W / SRX1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.46|P-value:1.53E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.23|P-value:3.41E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.26|P-value:3.31E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.18|P-value:4.54E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.00|P-value:8.77E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.45|P-value:1.55E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.99|P-value:1.49E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.23|P-value:3.77E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.37|P-value:2.18E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.24|P-value:3.36E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.39|P-value:2.01E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:4.67|P-value:5.13E-7 ID:SGTC_991|Compound:3996-0057|FD-Score:3.05|P-value:7.19E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.53|P-value:1.04E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-2.96|P-value:9.43E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.12|P-value:5.62E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.45|P-value:1.55E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.97|P-value:1.52E-5 ID:SGTC_1775|Compound:st081588|FD-Score:-3.29|P-value:2.77E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-2.94|P-value:9.99E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.10|P-value:5.98E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.70|P-value:4.56E-7 ID:SGTC_1948|Compound:st076329|FD-Score:3.25|P-value:3.38E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.89|P-value:2.19E-5 ID:SGTC_1979|Compound:st071809|FD-Score:4.22|P-value:5.21E-6 ID:SGTC_2004|Compound:4023728|FD-Score:3.20|P-value:4.11E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.14|P-value:5.11E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.27|P-value:3.20E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.21|P-value:3.66E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.35|P-value:2.33E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-4.75|P-value:3.02E-7 ID:SGTC_2707|Compound:st078556|FD-Score:3.03|P-value:7.73E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.04|P-value:7.49E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.04|P-value:7.04E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:2.99|P-value:8.95E-4 ID:SGTC_2854|Compound:9024559|FD-Score:4.81|P-value:2.41E-7 ID:SGTC_2870|Compound:9038528|FD-Score:3.09|P-value:6.20E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.06|P-value:6.88E-4 ID:SGTC_2959|Compound:9079155|FD-Score:4.14|P-value:7.49E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-3.49|P-value:1.25E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.27|P-value:3.23E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.03|P-value:7.77E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.48|P-value:1.42E-6 ID:SGTC_49|Compound:0717-0965|FD-Score:3.46|P-value:1.53E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.23|P-value:3.41E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.26|P-value:3.31E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.18|P-value:4.54E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.00|P-value:8.77E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.45|P-value:1.55E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.99|P-value:1.49E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.23|P-value:3.77E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.37|P-value:2.18E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.24|P-value:3.36E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.39|P-value:2.01E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:4.67|P-value:5.13E-7 ID:SGTC_991|Compound:3996-0057|FD-Score:3.05|P-value:7.19E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.53|P-value:1.04E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-2.96|P-value:9.43E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.12|P-value:5.62E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.45|P-value:1.55E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.97|P-value:1.52E-5 ID:SGTC_1775|Compound:st081588|FD-Score:-3.29|P-value:2.77E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-2.94|P-value:9.99E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.10|P-value:5.98E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.70|P-value:4.56E-7 ID:SGTC_1948|Compound:st076329|FD-Score:3.25|P-value:3.38E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.89|P-value:2.19E-5 ID:SGTC_1979|Compound:st071809|FD-Score:4.22|P-value:5.21E-6 ID:SGTC_2004|Compound:4023728|FD-Score:3.20|P-value:4.11E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.14|P-value:5.11E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.27|P-value:3.20E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.21|P-value:3.66E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.35|P-value:2.33E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-4.75|P-value:3.02E-7 ID:SGTC_2707|Compound:st078556|FD-Score:3.03|P-value:7.73E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.04|P-value:7.49E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.04|P-value:7.04E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:2.99|P-value:8.95E-4 ID:SGTC_2854|Compound:9024559|FD-Score:4.81|P-value:2.41E-7 ID:SGTC_2870|Compound:9038528|FD-Score:3.09|P-value:6.20E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.06|P-value:6.88E-4 ID:SGTC_2959|Compound:9079155|FD-Score:4.14|P-value:7.49E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-3.49|P-value:1.25E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.27|P-value:3.23E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.03|P-value:7.77E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.48|P-value:1.42E-6

Top fitness defect scores for YKL086W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2854 9024559 4.81 71.4 µM 2.41E-7 9 7.41E-7
2 SGTC_1940 st075990 4.70 51.1 µM 4.56E-7 60S ribosome export 8 1.33E-6
3 SGTC_988 1497-1057 4.67 103.0 µM 5.13E-7 4 1.48E-6
4 SGTC_3329 9141233 4.48 27.6 µM 1.42E-6 10 3.75E-6
5 SGTC_1979 st071809 4.22 45.3 µM 5.21E-6 RPP1 & pyrimidine depletion 7 1.24E-5
6 SGTC_2959 9079155 4.14 11.0 µM 7.49E-6 24 1.73E-5
7 SGTC_334 1502-1024 3.99 68.5 µM 1.49E-5 12 3.24E-5
8 SGTC_49 0717-0965 3.46 32.1 µM 1.53E-4 60S ribosome export 39 2.75E-4
9 SGTC_277 nystatin 3.45 15.5 µM 1.55E-4 28 2.78E-4
10 SGTC_1678 st019265 3.45 80.2 µM 1.55E-4 60S ribosome export 39 2.79E-4
11 SGTC_871 0574-0004 3.39 149.0 µM 2.01E-4 68 3.53E-4
12 SGTC_458 nppb 3.37 133.0 µM 2.18E-4 27 3.81E-4
13 SGTC_2346 9031566 3.35 143.8 µM 2.33E-4 Golgi 47 4.04E-4
14 SGTC_2007 4011539 3.27 71.8 µM 3.20E-4 cell wall signaling 89 5.41E-4
15 SGTC_3164 9100705 3.27 49.5 µM 3.23E-4 17 5.46E-4
16 SGTC_164 4100-3994 3.26 89.6 µM 3.31E-4 68 5.58E-4
17 SGTC_1948 st076329 3.25 66.6 µM 3.38E-4 57 5.69E-4
18 SGTC_343 4130-2827 3.23 29.8 µM 3.77E-4 63 6.29E-4
19 SGTC_2004 4023728 3.20 41.9 µM 4.11E-4 61 6.82E-4
20 SGTC_240 5hr heat shock (37°C) + Streptovitacin 3.18 300.0 µM 4.54E-4 heat shock/prefoldin 70 7.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.54E-11 YIL012W_d YIL012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.112 9.67E-11 YOR013W_d IRC11_d hom Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
0.097 1.83E-8 YOR127W RGA1 hom GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.089 2.79E-7 YDR130C FIN1 hom Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress
0.087 4.64E-7 YKL070W_p YKL070W_p hom Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.084 1.26E-6 YFR025C HIS2 hom Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
0.082 1.73E-6 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
0.074 1.94E-5 YPR154W PIN3 hom Protein that induces appearance of [PIN+] prion when overproduced
0.073 2.19E-5 YML099C ARG81 hom Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
0.073 2.32E-5 YDR424C DYN2 hom Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex
0.071 3.99E-5 YJL035C TAD2 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.071 4.26E-5 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.070 4.64E-5 YER033C ZRG8 hom Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
0.070 5.58E-5 YLR307W CDA1 hom Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.068 8.23E-5 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase