YKL088W / CAB3

Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL088W / CAB3

Click on Significant Values for Screen Details ID:SGTC_79|Compound:0052-0007|FD-Score:3.06|P-value:4.07E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.16|P-value:2.70E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.08|P-value:3.72E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:2.82|P-value:9.93E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.28|P-value:1.65E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.49|P-value:6.74E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:3.64|P-value:3.48E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:3.18|P-value:2.55E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.20|P-value:2.24E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.93|P-value:8.76E-11 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.02|P-value:6.31E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.12|P-value:3.16E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-3.13|P-value:4.07E-4 ID:SGTC_1761|Compound:st044296|FD-Score:2.85|P-value:8.87E-4 ID:SGTC_1831|Compound:st055328|FD-Score:2.88|P-value:7.95E-4 ID:SGTC_1860|Compound:st056228|FD-Score:2.97|P-value:5.77E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.06|P-value:5.42E-4 ID:SGTC_2049|Compound:5262831|FD-Score:2.94|P-value:6.39E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.78|P-value:1.81E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.79|P-value:1.76E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.19|P-value:2.40E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-2.98|P-value:7.26E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.48|P-value:9.55E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-3.64|P-value:4.93E-5 ID:SGTC_2313|Compound:7726885|FD-Score:2.86|P-value:8.57E-4 ID:SGTC_2399|Compound:5884133|FD-Score:5.78|P-value:1.58E-10 ID:SGTC_2400|Compound:5203494|FD-Score:-3.11|P-value:4.45E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.58|P-value:6.23E-5 ID:SGTC_2448|Compound:5185112|FD-Score:-3.16|P-value:3.65E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.19|P-value:2.41E-4 ID:SGTC_2473|Compound:5854593|FD-Score:2.94|P-value:6.41E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.26|P-value:2.46E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.11|P-value:4.44E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.04|P-value:5.81E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:-3.77|P-value:2.65E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.59|P-value:6.11E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.59|P-value:5.98E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.97|P-value:1.03E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.00|P-value:5.03E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.04|P-value:4.30E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-2.94|P-value:8.34E-4 ID:SGTC_2874|Compound:9043904|FD-Score:2.96|P-value:5.84E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.07|P-value:3.91E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.29|P-value:1.57E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-6.09|P-value:2.89E-11 ID:SGTC_3067|Compound:9117431|FD-Score:3.84|P-value:1.33E-5 ID:SGTC_3072|Compound:9116419|FD-Score:3.64|P-value:3.50E-5 ID:SGTC_3078|Compound:9116413|FD-Score:3.77|P-value:1.93E-5 ID:SGTC_3085|Compound:9117376|FD-Score:3.88|P-value:1.14E-5 ID:SGTC_3228|Compound:9131799|FD-Score:3.89|P-value:1.07E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.65|P-value:1.95E-7 ID:SGTC_3321|Compound:9137793|FD-Score:-2.91|P-value:9.23E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.06|P-value:4.07E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.16|P-value:2.70E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.08|P-value:3.72E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:2.82|P-value:9.93E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.28|P-value:1.65E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.49|P-value:6.74E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:3.64|P-value:3.48E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:3.18|P-value:2.55E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.20|P-value:2.24E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.93|P-value:8.76E-11 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.02|P-value:6.31E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.12|P-value:3.16E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-3.13|P-value:4.07E-4 ID:SGTC_1761|Compound:st044296|FD-Score:2.85|P-value:8.87E-4 ID:SGTC_1831|Compound:st055328|FD-Score:2.88|P-value:7.95E-4 ID:SGTC_1860|Compound:st056228|FD-Score:2.97|P-value:5.77E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.06|P-value:5.42E-4 ID:SGTC_2049|Compound:5262831|FD-Score:2.94|P-value:6.39E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.78|P-value:1.81E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.79|P-value:1.76E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.19|P-value:2.40E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-2.98|P-value:7.26E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.48|P-value:9.55E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-3.64|P-value:4.93E-5 ID:SGTC_2313|Compound:7726885|FD-Score:2.86|P-value:8.57E-4 ID:SGTC_2399|Compound:5884133|FD-Score:5.78|P-value:1.58E-10 ID:SGTC_2400|Compound:5203494|FD-Score:-3.11|P-value:4.45E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.58|P-value:6.23E-5 ID:SGTC_2448|Compound:5185112|FD-Score:-3.16|P-value:3.65E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.19|P-value:2.41E-4 ID:SGTC_2473|Compound:5854593|FD-Score:2.94|P-value:6.41E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.26|P-value:2.46E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.11|P-value:4.44E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.04|P-value:5.81E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:-3.77|P-value:2.65E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.59|P-value:6.11E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.59|P-value:5.98E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.97|P-value:1.03E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.00|P-value:5.03E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.04|P-value:4.30E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-2.94|P-value:8.34E-4 ID:SGTC_2874|Compound:9043904|FD-Score:2.96|P-value:5.84E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.07|P-value:3.91E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.29|P-value:1.57E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-6.09|P-value:2.89E-11 ID:SGTC_3067|Compound:9117431|FD-Score:3.84|P-value:1.33E-5 ID:SGTC_3072|Compound:9116419|FD-Score:3.64|P-value:3.50E-5 ID:SGTC_3078|Compound:9116413|FD-Score:3.77|P-value:1.93E-5 ID:SGTC_3085|Compound:9117376|FD-Score:3.88|P-value:1.14E-5 ID:SGTC_3228|Compound:9131799|FD-Score:3.89|P-value:1.07E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.65|P-value:1.95E-7 ID:SGTC_3321|Compound:9137793|FD-Score:-2.91|P-value:9.23E-4

Top fitness defect scores for YKL088W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2399 5884133 5.78 200.0 µM 1.58E-10 cell wall signaling 7 3.80E-9 0.05
2 SGTC_3272 9137413 4.65 49.5 µM 1.95E-7 2 1.64E-6 0.48
3 SGTC_1040 k898-0338 4.20 155.0 µM 2.24E-6 2 1.32E-5 1.18
4 SGTC_3228 9131799 3.89 49.5 µM 1.07E-5 amide catabolism 2 4.98E-5 0.09
5 SGTC_3085 9117376 3.88 49.5 µM 1.14E-5 7 5.26E-5 0.04
6 SGTC_3067 9117431 3.84 49.5 µM 1.33E-5 10 6.03E-5 0.20
7 SGTC_2113 5491891 3.79 107.0 µM 1.76E-5 TSC3-RPN4 8 7.64E-5 0.26
8 SGTC_2059 5238311 3.78 157.0 µM 1.81E-5 5 7.81E-5 0.03
9 SGTC_3078 9116413 3.77 49.5 µM 1.93E-5 unfolded protein response 7 8.28E-5 0.17
10 SGTC_807 1315-0151 3.64 48.0 µM 3.48E-5 9 1.37E-4 0.02
11 SGTC_3072 9116419 3.64 49.5 µM 3.50E-5 ERG2 7 1.37E-4 0.03
12 SGTC_734 2023-0417 3.49 80.0 µM 6.74E-5 ergosterol biosynthesis 13 2.40E-4 0.03
13 SGTC_3037 9091026 3.29 49.5 µM 1.57E-4 NEO1-PIK1 28 4.96E-4 0.29
14 SGTC_537 1334-0398 3.28 209.0 µM 1.65E-4 14 5.18E-4 0.13
15 SGTC_2147 5545932 3.19 89.7 µM 2.40E-4 ergosterol biosynthesis 20 7.11E-4 0.07
16 SGTC_2456 5770359 3.19 74.5 µM 2.41E-4 11 7.13E-4 0.11
17 SGTC_838 0109-0203 3.18 71.4 µM 2.55E-4 9 7.48E-4 0.02
18 SGTC_334 1502-1024 3.16 68.5 µM 2.70E-4 6 7.87E-4 0.09
19 SGTC_1528 arabinosylhypoxanthine 3.12 74.6 µM 3.16E-4 18 9.00E-4 0.03
20 SGTC_368 fentichlor 3.08 4.6 µM 3.72E-4 11 0.00103 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 8.57E-15 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.126 2.12E-13 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.122 1.29E-12 YGR198W YPP1 het Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
0.114 3.07E-11 YDR531W CAB1 het Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
0.113 4.84E-11 YOL022C TSR4 het Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
0.113 5.32E-11 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.109 2.29E-10 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.108 3.81E-10 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.105 1.04E-9 YJL183W MNN11 hom Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
0.105 1.16E-9 YFR004W RPN11 het Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress
0.103 1.85E-9 YER018C SPC25 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.102 2.97E-9 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.101 4.57E-9 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.100 6.50E-9 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.099 9.69E-9 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria