YKL090W / CUE2

Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL090W / CUE2

Click on Significant Values for Screen Details ID:SGTC_168|Compound:3970-0862|FD-Score:-3.14|P-value:6.88E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.09|P-value:7.46E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.64|P-value:1.01E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.80|P-value:5.28E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.80|P-value:5.15E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.32|P-value:3.24E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:-3.38|P-value:2.85E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-4.94|P-value:2.25E-7 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.05|P-value:9.37E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.11|P-value:6.95E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.29|P-value:3.88E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.89|P-value:3.12E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.70|P-value:6.95E-7 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.25|P-value:6.22E-6 ID:SGTC_1893|Compound:st059353|FD-Score:3.16|P-value:5.66E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.03|P-value:9.01E-4 ID:SGTC_1966|Compound:st070145|FD-Score:5.51|P-value:7.71E-9 ID:SGTC_2107|Compound:5363541|FD-Score:-3.97|P-value:2.47E-5 ID:SGTC_2118|Compound:5526350|FD-Score:4.09|P-value:1.28E-5 ID:SGTC_2316|Compound:5844804|FD-Score:-4.51|P-value:2.00E-6 ID:SGTC_2320|Compound:7373003|FD-Score:-3.28|P-value:4.07E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.16|P-value:5.68E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:8.80|P-value:8.57E-20 ID:SGTC_2428|Compound:5615643|FD-Score:4.84|P-value:3.28E-7 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.88|P-value:3.34E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.58|P-value:1.18E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.06|P-value:8.16E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.54|P-value:1.38E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.43|P-value:2.33E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-4.30|P-value:5.49E-6 ID:SGTC_2975|Compound:9084847|FD-Score:-3.17|P-value:6.12E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.27|P-value:3.81E-4 ID:SGTC_2992|Compound:9074591|FD-Score:6.79|P-value:1.62E-12 ID:SGTC_3050|Compound:9093513|FD-Score:3.31|P-value:3.37E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.89|P-value:3.55E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.11|P-value:6.90E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.14|P-value:6.88E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.09|P-value:7.46E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.64|P-value:1.01E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.80|P-value:5.28E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.80|P-value:5.15E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.32|P-value:3.24E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:-3.38|P-value:2.85E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-4.94|P-value:2.25E-7 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.05|P-value:9.37E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.11|P-value:6.95E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.29|P-value:3.88E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.89|P-value:3.12E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.70|P-value:6.95E-7 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.25|P-value:6.22E-6 ID:SGTC_1893|Compound:st059353|FD-Score:3.16|P-value:5.66E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.03|P-value:9.01E-4 ID:SGTC_1966|Compound:st070145|FD-Score:5.51|P-value:7.71E-9 ID:SGTC_2107|Compound:5363541|FD-Score:-3.97|P-value:2.47E-5 ID:SGTC_2118|Compound:5526350|FD-Score:4.09|P-value:1.28E-5 ID:SGTC_2316|Compound:5844804|FD-Score:-4.51|P-value:2.00E-6 ID:SGTC_2320|Compound:7373003|FD-Score:-3.28|P-value:4.07E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.16|P-value:5.68E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:8.80|P-value:8.57E-20 ID:SGTC_2428|Compound:5615643|FD-Score:4.84|P-value:3.28E-7 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.88|P-value:3.34E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.58|P-value:1.18E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.06|P-value:8.16E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.54|P-value:1.38E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.43|P-value:2.33E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-4.30|P-value:5.49E-6 ID:SGTC_2975|Compound:9084847|FD-Score:-3.17|P-value:6.12E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.27|P-value:3.81E-4 ID:SGTC_2992|Compound:9074591|FD-Score:6.79|P-value:1.62E-12 ID:SGTC_3050|Compound:9093513|FD-Score:3.31|P-value:3.37E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.89|P-value:3.55E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.11|P-value:6.90E-4

Top fitness defect scores for YKL090W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2405 ticlatone 8.80 3.5 µM 8.57E-20 14 6.85E-19
2 SGTC_2992 9074591 6.79 71.4 µM 1.62E-12 1 5.75E-12
3 SGTC_1966 st070145 5.51 16.1 µM 7.71E-9 8 1.82E-8
4 SGTC_2428 5615643 4.84 7.8 µM 3.28E-7 23 6.44E-7
5 SGTC_1509 1326-1131 4.70 80.0 µM 6.95E-7 5 1.32E-6
6 SGTC_1513 0337-0559 4.25 19.0 µM 6.22E-6 12 1.06E-5
7 SGTC_2118 5526350 4.09 200.0 µM 1.28E-5 14 2.11E-5
8 SGTC_1387 3342-1166 3.89 1.8 µM 3.12E-5 mitochondrial processes 16 4.93E-5
9 SGTC_2573 2',4'-dihydroxychalcone 3.88 15.0 µM 3.34E-5 52 5.25E-5
10 SGTC_2659 sanguinarine 3.58 24.2 µM 1.18E-4 32 1.75E-4
11 SGTC_2702 st077768 3.54 96.8 µM 1.38E-4 23 2.03E-4
12 SGTC_820 1582-0060 3.32 59.9 µM 3.24E-4 60 4.57E-4
13 SGTC_3050 9093513 3.31 49.5 µM 3.37E-4 33 4.75E-4
14 SGTC_2991 9074669 3.27 71.4 µM 3.81E-4 azole & statin 101 5.34E-4
15 SGTC_1893 st059353 3.16 36.1 µM 5.66E-4 56 7.77E-4
16 SGTC_2330 7979373 3.16 200.0 µM 5.68E-4 60S ribosome export 66 7.80E-4
17 SGTC_3272 9137413 3.11 49.5 µM 6.90E-4 47 9.39E-4
18 SGTC_1327 1436-0082 3.11 2.2 µM 6.95E-4 52 9.46E-4
19 SGTC_305 1682-2595 3.09 20.8 µM 7.46E-4 RNA processing & uracil transport 51 0.00101
20 SGTC_2675 theaflavin digallate 3.06 100.0 µM 8.16E-4 iron homeostasis 68 0.00110

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.321 6.76E-81 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.134 7.72E-15 YKL101W HSL1 hom Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
0.120 2.76E-12 YOR173W DCS2 hom Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance
0.115 2.30E-11 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.105 9.12E-10 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.099 8.97E-9 YKL081W TEF4 hom Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex
0.098 1.10E-8 YOL094C RFC4 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.097 1.59E-8 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.097 1.94E-8 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.094 4.42E-8 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.094 4.47E-8 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.093 8.25E-8 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.091 1.19E-7 YCR001W_d YCR001W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
0.083 1.42E-6 YOR323C PRO2 hom Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
0.082 1.74E-6 YKL144C RPC25 het RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p