YKL091C

Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL091C / YKL091C

Click on Significant Values for Screen Details ID:SGTC_183|Compound:3914-0051|FD-Score:3.15|P-value:9.32E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.43|P-value:3.42E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-4.70|P-value:1.47E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:5.00|P-value:3.63E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:3.51|P-value:2.64E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.13|P-value:9.11E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.98|P-value:4.09E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.30|P-value:5.16E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.17|P-value:8.07E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.30|P-value:5.04E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-5.06|P-value:2.51E-7 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.31|P-value:4.95E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.57|P-value:3.01E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.81|P-value:8.23E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.63|P-value:1.50E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.49|P-value:2.60E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.14|P-value:9.55E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.91|P-value:5.10E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.19|P-value:1.69E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.25|P-value:1.30E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.14|P-value:9.57E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-5.36|P-value:4.90E-8 ID:SGTC_1755|Compound:st041960|FD-Score:-3.28|P-value:5.54E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.56|P-value:2.14E-4 ID:SGTC_1807|Compound:st050092|FD-Score:-3.19|P-value:7.60E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.42|P-value:3.31E-4 ID:SGTC_1886|Compound:st057356|FD-Score:4.21|P-value:1.53E-5 ID:SGTC_1903|Compound:st060211|FD-Score:-3.28|P-value:5.57E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.49|P-value:2.54E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.13|P-value:2.16E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.58|P-value:2.01E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.38|P-value:4.16E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.27|P-value:6.22E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.70|P-value:1.67E-6 ID:SGTC_2799|Compound:7812892|FD-Score:6.75|P-value:1.15E-11 ID:SGTC_2809|Compound:7964133|FD-Score:-3.35|P-value:4.33E-4 ID:SGTC_2822|Compound:7994718|FD-Score:4.14|P-value:2.07E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.94|P-value:4.93E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-3.12|P-value:9.47E-4 ID:SGTC_2937|Compound:9044753|FD-Score:5.34|P-value:6.28E-8 ID:SGTC_2989|Compound:9073649|FD-Score:-5.21|P-value:1.12E-7 ID:SGTC_3075|Compound:9116269|FD-Score:-3.36|P-value:4.13E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.30|P-value:5.13E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.31|P-value:4.87E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.15|P-value:9.32E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.43|P-value:3.42E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-4.70|P-value:1.47E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:5.00|P-value:3.63E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:3.51|P-value:2.64E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.13|P-value:9.11E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.98|P-value:4.09E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.30|P-value:5.16E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.17|P-value:8.07E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.30|P-value:5.04E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-5.06|P-value:2.51E-7 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.31|P-value:4.95E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.57|P-value:3.01E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.81|P-value:8.23E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.63|P-value:1.50E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.49|P-value:2.60E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.14|P-value:9.55E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.91|P-value:5.10E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.19|P-value:1.69E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.25|P-value:1.30E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.14|P-value:9.57E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-5.36|P-value:4.90E-8 ID:SGTC_1755|Compound:st041960|FD-Score:-3.28|P-value:5.54E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.56|P-value:2.14E-4 ID:SGTC_1807|Compound:st050092|FD-Score:-3.19|P-value:7.60E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.42|P-value:3.31E-4 ID:SGTC_1886|Compound:st057356|FD-Score:4.21|P-value:1.53E-5 ID:SGTC_1903|Compound:st060211|FD-Score:-3.28|P-value:5.57E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.49|P-value:2.54E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.13|P-value:2.16E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.58|P-value:2.01E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.38|P-value:4.16E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.27|P-value:6.22E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.70|P-value:1.67E-6 ID:SGTC_2799|Compound:7812892|FD-Score:6.75|P-value:1.15E-11 ID:SGTC_2809|Compound:7964133|FD-Score:-3.35|P-value:4.33E-4 ID:SGTC_2822|Compound:7994718|FD-Score:4.14|P-value:2.07E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.94|P-value:4.93E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-3.12|P-value:9.47E-4 ID:SGTC_2937|Compound:9044753|FD-Score:5.34|P-value:6.28E-8 ID:SGTC_2989|Compound:9073649|FD-Score:-5.21|P-value:1.12E-7 ID:SGTC_3075|Compound:9116269|FD-Score:-3.36|P-value:4.13E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.30|P-value:5.13E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.31|P-value:4.87E-4

Top fitness defect scores for YKL091C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2799 7812892 6.75 81.8 µM 1.15E-11 superoxide 6 7.37E-12
2 SGTC_2937 9044753 5.34 11.3 µM 6.28E-8 60S ribosome export 12 4.68E-8
3 SGTC_421 streptovitacin 5.00 30.0 mM 3.63E-7 6 2.79E-7
4 SGTC_601 0986-0029 4.98 62.9 µM 4.09E-7 calcium & mitochondrial duress 17 3.15E-7
5 SGTC_2792 7535235 4.70 81.8 µM 1.67E-6 fatty acid desaturase (OLE1) 20 1.32E-6
6 SGTC_902 1120-0002 4.57 2.1 µM 3.01E-6 azole & statin 31 2.41E-6
7 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 4.25 66.5 µM 1.30E-5 14 1.06E-5
8 SGTC_1886 st057356 4.21 49.9 µM 1.53E-5 60S ribosome export 12 1.26E-5
9 SGTC_1381 2324-0066 4.19 62.1 µM 1.69E-5 25 1.40E-5
10 SGTC_2822 7994718 4.14 71.4 µM 2.07E-5 14 1.71E-5
11 SGTC_1915 st067105 4.13 30.6 µM 2.16E-5 RNA pol III & RNase P/MRP 39 1.79E-5
12 SGTC_2929 9013348 3.94 24.6 µM 4.93E-5 19 4.14E-5
13 SGTC_939 1165-0479 3.81 45.3 µM 8.23E-5 31 6.98E-5
14 SGTC_2165 5727197 3.58 32.1 µM 2.01E-4 47 1.73E-4
15 SGTC_1766 st045414 3.56 44.8 µM 2.14E-4 RPP1 & pyrimidine depletion 42 1.84E-4
16 SGTC_425 3825-7017 3.51 13.1 µM 2.64E-4 37 2.28E-4
17 SGTC_264 promethazine 3.43 12.5 mM 3.42E-4 DNA intercalators 77 2.98E-4
18 SGTC_2456 5770359 3.38 74.5 µM 4.16E-4 27 3.63E-4
19 SGTC_1559 coumarin 343 3.29 70.1 µM 5.67E-4 27 4.97E-4
20 SGTC_2561 acetosyringone 3.27 100.0 µM 6.22E-4 54 5.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.25E-15 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.096 2.35E-8 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.094 5.70E-8 YBR250W SPO23 hom Protein of unknown function; associates with meiosis-specific protein Spo1p
0.090 1.90E-7 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.090 1.99E-7 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.083 1.32E-6 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.080 3.93E-6 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.079 4.83E-6 YIL013C PDR11 hom ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth
0.079 5.14E-6 YLR092W SUL2 hom High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.078 5.37E-6 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.078 5.38E-6 YML081W TDA9 hom DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.078 5.67E-6 YPL114W_d YPL114W_d hom Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
0.075 1.50E-5 YOR164C GET4 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
0.073 2.24E-5 YOR287C RRP36 het Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
0.072 3.09E-5 YBL103C RTG3 hom Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways