YKL093W / MBR1

Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL093W / MBR1

Click on Significant Values for Screen Details ID:SGTC_193|Compound:1273-0060|FD-Score:3.18|P-value:5.20E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.05|P-value:8.08E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.30|P-value:3.34E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.17|P-value:5.39E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.99|P-value:1.93E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.05|P-value:8.11E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.40|P-value:2.82E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.54|P-value:1.41E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.95|P-value:2.32E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.19|P-value:4.99E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.69|P-value:7.07E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.09|P-value:1.24E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.03|P-value:8.65E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.15|P-value:5.77E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.08|P-value:1.41E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.29|P-value:3.60E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.66|P-value:7.57E-7 ID:SGTC_1747|Compound:st037496|FD-Score:3.07|P-value:7.65E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.83|P-value:3.81E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.68|P-value:7.32E-5 ID:SGTC_1950|Compound:st077106|FD-Score:3.55|P-value:1.23E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.01|P-value:9.36E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.23|P-value:4.31E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.37|P-value:2.51E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.23|P-value:4.59E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.16|P-value:5.42E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.44|P-value:2.06E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.65|P-value:8.92E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.10|P-value:6.79E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.36|P-value:2.80E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.45|P-value:2.00E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.00|P-value:9.69E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.22|P-value:4.37E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.26|P-value:4.06E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.16|P-value:5.50E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.66|P-value:7.79E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.49|P-value:1.69E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.18|P-value:5.44E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.27|P-value:3.93E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.43|P-value:2.02E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.02|P-value:9.08E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.01|P-value:9.51E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.87|P-value:3.47E-5 ID:SGTC_3174|Compound:9107204|FD-Score:5.88|P-value:6.65E-10 ID:SGTC_3182|Compound:9108849|FD-Score:3.01|P-value:9.23E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.33|P-value:2.91E-4 ID:SGTC_3249|Compound:9135183|FD-Score:4.00|P-value:1.85E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:3.18|P-value:5.20E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.05|P-value:8.08E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.30|P-value:3.34E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.17|P-value:5.39E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.99|P-value:1.93E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.05|P-value:8.11E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.40|P-value:2.82E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.54|P-value:1.41E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.95|P-value:2.32E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.19|P-value:4.99E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.69|P-value:7.07E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.09|P-value:1.24E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.03|P-value:8.65E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.15|P-value:5.77E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-4.08|P-value:1.41E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.29|P-value:3.60E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.66|P-value:7.57E-7 ID:SGTC_1747|Compound:st037496|FD-Score:3.07|P-value:7.65E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.83|P-value:3.81E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.68|P-value:7.32E-5 ID:SGTC_1950|Compound:st077106|FD-Score:3.55|P-value:1.23E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.01|P-value:9.36E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.23|P-value:4.31E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.37|P-value:2.51E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.23|P-value:4.59E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.16|P-value:5.42E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.44|P-value:2.06E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.65|P-value:8.92E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.10|P-value:6.79E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.36|P-value:2.80E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.45|P-value:2.00E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.00|P-value:9.69E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.22|P-value:4.37E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.26|P-value:4.06E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.16|P-value:5.50E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.66|P-value:7.79E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.49|P-value:1.69E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.18|P-value:5.44E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.27|P-value:3.93E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.43|P-value:2.02E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.02|P-value:9.08E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.01|P-value:9.51E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.87|P-value:3.47E-5 ID:SGTC_3174|Compound:9107204|FD-Score:5.88|P-value:6.65E-10 ID:SGTC_3182|Compound:9108849|FD-Score:3.01|P-value:9.23E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.33|P-value:2.91E-4 ID:SGTC_3249|Compound:9135183|FD-Score:4.00|P-value:1.85E-5

Top fitness defect scores for YKL093W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3174 9107204 5.88 49.5 µM 6.65E-10 ERG2 5 2.05E-9
2 SGTC_1715 st032160 4.66 10.2 µM 7.57E-7 28 1.57E-6
3 SGTC_2472 5377652 4.66 49.4 µM 7.79E-7 TRP & mitochondrial translation 37 1.61E-6
4 SGTC_816 0325-0417 4.40 81.3 µM 2.82E-6 6 5.41E-6
5 SGTC_1325 1431-0015 4.09 227.0 µM 1.24E-5 Golgi 17 2.20E-5
6 SGTC_3249 9135183 4.00 49.5 µM 1.85E-5 60S ribosome export 8 3.20E-5
7 SGTC_649 1123-0311 3.99 367.0 µM 1.93E-5 endomembrane recycling 67 3.33E-5
8 SGTC_864 0469-0573 3.95 172.0 µM 2.32E-5 21 3.96E-5
9 SGTC_1750 st081859 3.83 2.4 µM 3.81E-5 endomembrane recycling 197 6.34E-5
10 SGTC_1320 1313-0481 3.69 95.3 µM 7.07E-5 30 1.13E-4
11 SGTC_1869 3',7'-dimethoxyflavone 3.68 40.3 µM 7.32E-5 34 1.17E-4
12 SGTC_1950 st077106 3.55 7.2 µM 1.23E-4 RNA processing & uracil transport 44 1.92E-4
13 SGTC_2834 9001755 3.43 58.4 µM 2.02E-4 52 3.07E-4
14 SGTC_2239 6685329 3.37 187.6 µM 2.51E-4 54 3.76E-4
15 SGTC_3187 9109394 3.33 49.5 µM 2.91E-4 Golgi 44 4.31E-4
16 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.30 150.0 µM 3.34E-4 Golgi 64 4.92E-4
17 SGTC_2165 5727197 3.23 32.1 µM 4.31E-4 67 6.25E-4
18 SGTC_2387 9077560 3.22 195.1 µM 4.37E-4 42 6.34E-4
19 SGTC_1083 didemethylchlorpromazine sulfoxide 3.19 707.4 nM 4.99E-4 redox potentiating 132 7.19E-4
20 SGTC_193 1273-0060 3.18 1.6 µM 5.20E-4 ergosterol biosynthesis 23 7.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.11E-14 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.121 2.15E-12 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.116 1.55E-11 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.114 4.17E-11 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.110 1.73E-10 YPR153W YPR153W hom Putative protein of unknown function
0.109 2.53E-10 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.108 3.43E-10 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.103 2.46E-9 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.101 5.24E-9 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.099 8.86E-9 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.096 2.82E-8 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.088 3.75E-7 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.086 5.33E-7 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.086 6.44E-7 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.085 7.73E-7 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex