HIPHOP chemogenomics database
YKL096W / CWP1 
Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKL096W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.105 | 9.20E-10 | YGL235W_p | YGL235W_p | hom | Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 |
| 0.100 | 6.86E-9 | YJL055W_p | YJL055W_p | hom | Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU |
| 0.099 | 8.65E-9 | YGR003W | CUL3 | hom | Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 |
| 0.094 | 5.61E-8 | YLR004C | THI73 | hom | Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs |
| 0.091 | 1.34E-7 | YOL141W | PPM2 | hom | AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p |
| 0.090 | 1.72E-7 | YKL082C | RRP14 | het | Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family |
| 0.089 | 2.25E-7 | YJR012C_p | YJR012C_p | het | Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W |
| 0.089 | 2.46E-7 | YKL201C | MNN4 | hom | Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication |
| 0.088 | 2.96E-7 | YDR336W_p | YDR336W_p | hom | Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene |
| 0.088 | 3.15E-7 | YLR131C | ACE2 | hom | Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
| 0.087 | 4.98E-7 | YPL187W | MF(ALPHA)1 | hom | Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor |
| 0.086 | 6.09E-7 | YML100W-A_p | YML100W-A_p | hom | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.078 | 5.55E-6 | YPL021W | ECM23 | hom | Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p |
| 0.078 | 5.77E-6 | YLR145W | RMP1 | het | Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P |
| 0.077 | 7.83E-6 | YKR046C | PET10 | hom | Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange |