YKL096W / CWP1

Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL096W / CWP1

Click on Significant Values for Screen Details ID:SGTC_113|Compound:0099-0221|FD-Score:3.10|P-value:3.60E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-2.91|P-value:7.32E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.41|P-value:9.98E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:2.88|P-value:8.36E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.40|P-value:1.00E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.51|P-value:6.24E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:2.94|P-value:6.68E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.72|P-value:2.42E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:2.93|P-value:6.99E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.39|P-value:1.01E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.11|P-value:3.40E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.47|P-value:7.54E-5 ID:SGTC_1981|Compound:st071826|FD-Score:2.85|P-value:9.16E-4 ID:SGTC_2004|Compound:4023728|FD-Score:2.95|P-value:6.29E-4 ID:SGTC_2369|Compound:9071472|FD-Score:2.91|P-value:7.38E-4 ID:SGTC_2443|Compound:5493264|FD-Score:5.92|P-value:5.07E-11 ID:SGTC_2446|Compound:5162541|FD-Score:-3.53|P-value:5.61E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.50|P-value:6.56E-5 ID:SGTC_2485|Compound:5633444|FD-Score:-3.09|P-value:3.51E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-2.87|P-value:8.42E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-2.88|P-value:8.06E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.85|P-value:1.28E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.48|P-value:7.09E-5 ID:SGTC_2841|Compound:9004761|FD-Score:2.87|P-value:8.48E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.26|P-value:1.88E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.29|P-value:1.63E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.58|P-value:2.89E-7 ID:SGTC_2927|Compound:9011802|FD-Score:3.29|P-value:1.66E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.56|P-value:5.02E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.74|P-value:2.07E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.08|P-value:3.88E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.10|P-value:3.60E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-2.91|P-value:7.32E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.41|P-value:9.98E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:2.88|P-value:8.36E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.40|P-value:1.00E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.51|P-value:6.24E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:2.94|P-value:6.68E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.72|P-value:2.42E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:2.93|P-value:6.99E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.39|P-value:1.01E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.11|P-value:3.40E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.47|P-value:7.54E-5 ID:SGTC_1981|Compound:st071826|FD-Score:2.85|P-value:9.16E-4 ID:SGTC_2004|Compound:4023728|FD-Score:2.95|P-value:6.29E-4 ID:SGTC_2369|Compound:9071472|FD-Score:2.91|P-value:7.38E-4 ID:SGTC_2443|Compound:5493264|FD-Score:5.92|P-value:5.07E-11 ID:SGTC_2446|Compound:5162541|FD-Score:-3.53|P-value:5.61E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.50|P-value:6.56E-5 ID:SGTC_2485|Compound:5633444|FD-Score:-3.09|P-value:3.51E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-2.87|P-value:8.42E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-2.88|P-value:8.06E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.85|P-value:1.28E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.48|P-value:7.09E-5 ID:SGTC_2841|Compound:9004761|FD-Score:2.87|P-value:8.48E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.26|P-value:1.88E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.29|P-value:1.63E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.58|P-value:2.89E-7 ID:SGTC_2927|Compound:9011802|FD-Score:3.29|P-value:1.66E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.56|P-value:5.02E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.74|P-value:2.07E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.08|P-value:3.88E-4

Top fitness defect scores for YKL096W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2443 5493264 5.92 126.7 µM 5.07E-11 7 1.65E-9
2 SGTC_2893 9048488 4.58 26.0 µM 2.89E-7 fatty acid desaturase (OLE1) 14 2.37E-6
3 SGTC_2819 7996655 3.85 46.4 µM 1.28E-5 25 5.82E-5
4 SGTC_972 1319-0219 3.72 195.0 µM 2.42E-5 38 9.94E-5
5 SGTC_2939 9044578 3.56 71.4 µM 5.02E-5 50 1.84E-4
6 SGTC_893 0958-0369 3.51 48.9 µM 6.24E-5 38 2.22E-4
7 SGTC_2476 5806916 3.50 10.5 µM 6.56E-5 24 2.31E-4
8 SGTC_2836 9010338 3.48 19.5 µM 7.09E-5 RPP1 & pyrimidine depletion 53 2.47E-4
9 SGTC_1701 st028638 3.47 40.4 µM 7.54E-5 26 2.60E-4
10 SGTC_183 3914-0051 3.41 30.6 µM 9.98E-5 60S ribosome export 40 3.30E-4
11 SGTC_2884 9058502 3.29 52.0 µM 1.63E-4 50 4.99E-4
12 SGTC_2927 9011802 3.29 47.9 µM 1.66E-4 48 5.07E-4
13 SGTC_2874 9043904 3.26 71.4 µM 1.88E-4 35 5.64E-4
14 SGTC_1442 4112-3290 3.11 3.0 µM 3.40E-4 41 9.32E-4
15 SGTC_113 0099-0221 3.10 2.5 µM 3.60E-4 66 9.78E-4
16 SGTC_3232 9132874 3.08 49.5 µM 3.88E-4 RPP1 & pyrimidine depletion 44 0.00104
17 SGTC_2004 4023728 2.95 41.9 µM 6.29E-4 77 0.00157
18 SGTC_934 2950-0684 2.94 338.0 µM 6.68E-4 63 0.00165
19 SGTC_1186 1319-0216 2.93 26.0 µM 6.99E-4 66 0.00171
20 SGTC_2369 9071472 2.91 200.0 µM 7.38E-4 58 0.00180

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 9.20E-10 YGL235W_p YGL235W_p hom Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.100 6.86E-9 YJL055W_p YJL055W_p hom Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU
0.099 8.65E-9 YGR003W CUL3 hom Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
0.094 5.61E-8 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.091 1.34E-7 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.090 1.72E-7 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.089 2.25E-7 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.089 2.46E-7 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.088 2.96E-7 YDR336W_p YDR336W_p hom Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
0.088 3.15E-7 YLR131C ACE2 hom Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
0.087 4.98E-7 YPL187W MF(ALPHA)1 hom Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
0.086 6.09E-7 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.078 5.55E-6 YPL021W ECM23 hom Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
0.078 5.77E-6 YLR145W RMP1 het Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
0.077 7.83E-6 YKR046C PET10 hom Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange