YKL096W-A / CWP2

Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL096W-A / CWP2

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.15|P-value:8.32E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.96|P-value:3.87E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:3.22|P-value:6.45E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.73|P-value:9.81E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.27|P-value:5.36E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:4.66|P-value:1.65E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:3.16|P-value:8.07E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.55|P-value:1.99E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.23|P-value:6.20E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.37|P-value:3.87E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.15|P-value:8.18E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.45|P-value:2.89E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.13|P-value:8.79E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.15|P-value:8.31E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.50|P-value:2.41E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.29|P-value:5.05E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.60|P-value:1.62E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.52|P-value:2.20E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.24|P-value:5.83E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.35|P-value:7.08E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.18|P-value:7.43E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.49|P-value:3.70E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.10|P-value:2.08E-5 ID:SGTC_1519|Compound:esterone|FD-Score:3.40|P-value:3.49E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.53|P-value:2.14E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.31|P-value:4.63E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.27|P-value:5.43E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.44|P-value:2.95E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.30|P-value:4.88E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.52|P-value:3.18E-6 ID:SGTC_2319|Compound:6033012|FD-Score:-3.09|P-value:9.78E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.74|P-value:9.39E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.77|P-value:9.63E-7 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.70|P-value:1.09E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.11|P-value:1.98E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.21|P-value:6.67E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.55|P-value:1.94E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.53|P-value:2.97E-6 ID:SGTC_2814|Compound:7977482|FD-Score:3.28|P-value:5.20E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.13|P-value:8.86E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.45|P-value:2.87E-4 ID:SGTC_2986|Compound:9022445|FD-Score:5.85|P-value:2.57E-9 ID:SGTC_3040|Compound:9091894|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_3307|Compound:9126885|FD-Score:5.04|P-value:2.45E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.15|P-value:8.32E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.96|P-value:3.87E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:3.22|P-value:6.45E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.73|P-value:9.81E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.27|P-value:5.36E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:4.66|P-value:1.65E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:3.16|P-value:8.07E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.55|P-value:1.99E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.23|P-value:6.20E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.37|P-value:3.87E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.15|P-value:8.18E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.45|P-value:2.89E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.13|P-value:8.79E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.15|P-value:8.31E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.50|P-value:2.41E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.29|P-value:5.05E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.60|P-value:1.62E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.52|P-value:2.20E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.24|P-value:5.83E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.35|P-value:7.08E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.18|P-value:7.43E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.49|P-value:3.70E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.10|P-value:2.08E-5 ID:SGTC_1519|Compound:esterone|FD-Score:3.40|P-value:3.49E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.53|P-value:2.14E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.31|P-value:4.63E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.27|P-value:5.43E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.44|P-value:2.95E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.30|P-value:4.88E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.52|P-value:3.18E-6 ID:SGTC_2319|Compound:6033012|FD-Score:-3.09|P-value:9.78E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.74|P-value:9.39E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.77|P-value:9.63E-7 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.70|P-value:1.09E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.11|P-value:1.98E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.21|P-value:6.67E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.55|P-value:1.94E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.53|P-value:2.97E-6 ID:SGTC_2814|Compound:7977482|FD-Score:3.28|P-value:5.20E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.13|P-value:8.86E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.45|P-value:2.87E-4 ID:SGTC_2986|Compound:9022445|FD-Score:5.85|P-value:2.57E-9 ID:SGTC_3040|Compound:9091894|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_3307|Compound:9126885|FD-Score:5.04|P-value:2.45E-7

Top fitness defect scores for YKL096W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2986 9022445 5.85 71.4 µM 2.57E-9 5 2.47E-9
2 SGTC_3307 9126885 5.04 69.3 µM 2.45E-7 15 2.38E-7
3 SGTC_2604 4'-hydroxychalcone 4.77 11.3 µM 9.63E-7 21 9.35E-7
4 SGTC_220 paclitaxel 4.66 373.4 µM 1.65E-6 2 1.60E-6
5 SGTC_2804 7954240 4.53 19.5 µM 2.97E-6 23 2.89E-6
6 SGTC_2261 9010538 4.52 184.7 µM 3.18E-6 10 3.09E-6
7 SGTC_1317 1273-0028 4.49 910.0 nM 3.70E-6 azole & statin 37 3.60E-6
8 SGTC_1302 1159-0335 4.35 255.0 µM 7.08E-6 8 6.90E-6
9 SGTC_2770 toltrazuril 4.11 17.5 µM 1.98E-5 22 1.94E-5
10 SGTC_1515 3460-0031 4.10 42.1 µM 2.08E-5 DNA intercalators 16 2.03E-5
11 SGTC_85 0868-0259 3.96 160.1 µM 3.87E-5 60S ribosome export 8 3.78E-5
12 SGTC_2323 6148992 3.74 148.3 µM 9.39E-5 43 9.19E-5
13 SGTC_145 3737-0113 3.73 38.4 µM 9.81E-5 DNA intercalators 82 9.60E-5
14 SGTC_2613 3',4'-dimethoxydalbergione 3.70 24.6 µM 1.09E-4 31 1.07E-4
15 SGTC_1147 3809-1045 3.67 12.3 µM 1.25E-4 31 1.22E-4
16 SGTC_3040 9091894 3.63 49.5 µM 1.44E-4 DNA intercalators 24 1.41E-4
17 SGTC_948 3448-0295 3.60 75.3 µM 1.62E-4 40 1.59E-4
18 SGTC_264 promethazine 3.55 12.5 mM 1.99E-4 DNA intercalators 68 1.95E-4
19 SGTC_1532 4',5'-dihydroxyflavone 3.53 78.7 µM 2.14E-4 Golgi 28 2.10E-4
20 SGTC_1078 idebenone 3.52 36.1 µM 2.20E-4 Golgi 57 2.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 8.56E-32 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.183 1.65E-26 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.171 2.29E-23 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.166 3.78E-22 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.166 5.43E-22 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.156 1.05E-19 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.156 1.24E-19 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.152 9.55E-19 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.144 5.08E-17 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.133 1.05E-14 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.116 1.65E-11 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 1.99E-11 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.114 3.13E-11 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.113 5.81E-11 YLR133W CKI1 hom Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication
0.110 1.73E-10 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles