YKL097C_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL097C / YKL097C

Click on Significant Values for Screen Details ID:SGTC_209|Compound:4077-0173|FD-Score:-3.69|P-value:2.95E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:-2.84|P-value:9.89E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.32|P-value:1.48E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.60|P-value:4.36E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.66|P-value:3.63E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:2.97|P-value:6.30E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.04|P-value:4.87E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-2.88|P-value:8.45E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:-2.90|P-value:7.99E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.43|P-value:9.18E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.44|P-value:9.05E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:2.86|P-value:9.70E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:4.37|P-value:1.07E-6 ID:SGTC_981|Compound:1488-1094|FD-Score:-4.47|P-value:5.53E-7 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.28|P-value:1.86E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.00|P-value:5.50E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-4.73|P-value:1.33E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.58|P-value:4.79E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.56|P-value:5.58E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.14|P-value:3.25E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.93|P-value:7.05E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.62|P-value:2.62E-7 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.13|P-value:3.48E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-3.54|P-value:5.76E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.24|P-value:2.16E-4 ID:SGTC_1895|Compound:st058434|FD-Score:2.86|P-value:9.55E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.67|P-value:3.47E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.18|P-value:2.64E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.15|P-value:3.17E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.47|P-value:7.96E-5 ID:SGTC_2814|Compound:7977482|FD-Score:5.06|P-value:2.01E-8 ID:SGTC_2913|Compound:7966556|FD-Score:3.48|P-value:7.99E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-2.85|P-value:9.58E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.43|P-value:9.45E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-4.22|P-value:2.15E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.17|P-value:2.89E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:-3.69|P-value:2.95E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:-2.84|P-value:9.89E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.32|P-value:1.48E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.60|P-value:4.36E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.66|P-value:3.63E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:2.97|P-value:6.30E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.04|P-value:4.87E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-2.88|P-value:8.45E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:-2.90|P-value:7.99E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.43|P-value:9.18E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.44|P-value:9.05E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:2.86|P-value:9.70E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:4.37|P-value:1.07E-6 ID:SGTC_981|Compound:1488-1094|FD-Score:-4.47|P-value:5.53E-7 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.28|P-value:1.86E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.00|P-value:5.50E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-4.73|P-value:1.33E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.58|P-value:4.79E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.56|P-value:5.58E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.14|P-value:3.25E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.93|P-value:7.05E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.62|P-value:2.62E-7 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.13|P-value:3.48E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-3.54|P-value:5.76E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.24|P-value:2.16E-4 ID:SGTC_1895|Compound:st058434|FD-Score:2.86|P-value:9.55E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.67|P-value:3.47E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.18|P-value:2.64E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.15|P-value:3.17E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.47|P-value:7.96E-5 ID:SGTC_2814|Compound:7977482|FD-Score:5.06|P-value:2.01E-8 ID:SGTC_2913|Compound:7966556|FD-Score:3.48|P-value:7.99E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-2.85|P-value:9.58E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.43|P-value:9.45E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-4.22|P-value:2.15E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.17|P-value:2.89E-4

Top fitness defect scores for YKL097C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2814 7977482 5.06 43.0 µM 2.01E-8 20 2.14E-7
2 SGTC_1261 0712-0010 4.62 12.7 µM 2.62E-7 RNA processing & uracil transport 13 1.91E-6
3 SGTC_979 1426-2828 4.37 121.0 µM 1.07E-6 15 6.35E-6
4 SGTC_2342 7990637 3.67 118.9 µM 3.47E-5 RNA processing & uracil transport 49 1.24E-4
5 SGTC_623 k072-0108 3.66 16.9 µM 3.63E-5 heme biosynthesis & mitochondrial translocase 29 1.28E-4
6 SGTC_1179 1021-1431 3.56 9.3 µM 5.58E-5 64 1.85E-4
7 SGTC_2913 7966556 3.48 36.6 µM 7.99E-5 60S ribosome export 23 2.52E-4
8 SGTC_1040 k898-0338 3.28 155.0 µM 1.86E-4 41 5.20E-4
9 SGTC_1894 3',6'-dihydroxyflavone 3.24 78.7 µM 2.16E-4 34 5.91E-4
10 SGTC_2999 9069765 3.17 71.4 µM 2.89E-4 amide catabolism 62 7.58E-4
11 SGTC_2661 dactinomycin 3.15 13.0 µM 3.17E-4 redox potentiating 52 8.21E-4
12 SGTC_1227 3909-8010 3.14 46.6 µM 3.25E-4 53 8.38E-4
13 SGTC_1332 1480-0653 3.13 17.5 µM 3.48E-4 TSC3-RPN4 40 8.87E-4
14 SGTC_644 1498-1197 3.04 63.3 µM 4.87E-4 71 0.00118
15 SGTC_634 1611-4317 2.97 11.2 µM 6.30E-4 ERG2 56 0.00148
16 SGTC_1895 st058434 2.86 18.3 µM 9.55E-4 55 0.00211
17 SGTC_964 1287-0107 2.86 19.4 µM 9.70E-4 cell wall 102 0.00214
18 SGTC_1432 4049-0298 2.84 68.4 µM 0.00102 42 0.00223
19 SGTC_780 0109-0199 2.84 192.0 µM 0.00103 78 0.00225
20 SGTC_1592 4',5'-dihydroxyflavone 2.81 8.8 µM 0.00114 60S ribosome export 70 0.00246

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.72E-24 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.133 9.71E-15 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
0.102 2.87E-9 YNL035C YNL035C hom Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress
0.097 1.61E-8 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.096 2.26E-8 YBL027W RPL19B hom Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication
0.094 4.51E-8 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.090 1.55E-7 YMR171C EAR1 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p
0.088 3.18E-7 YDR522C SPS2 hom Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component
0.087 3.92E-7 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.086 6.71E-7 YIL114C POR2 hom Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication
0.085 9.07E-7 YLR267W_p BOP2_p hom Protein of unknown function
0.085 9.25E-7 YJL131C AIM23 hom Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
0.084 1.04E-6 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.083 1.30E-6 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.082 1.76E-6 YMR147W_p YMR147W_p hom Putative protein of unknown function