YKL098W / MTC2

Protein of unknown function; mtc2 is synthetically sick with cdc13-1

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL098W / MTC2

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.02|P-value:2.22E-6 ID:SGTC_56|Compound:0957-0365|FD-Score:5.12|P-value:1.40E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.51|P-value:1.03E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:3.72|P-value:3.58E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:6.69|P-value:4.17E-10 ID:SGTC_91|Compound:0417-1751|FD-Score:3.98|P-value:1.46E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.61|P-value:1.29E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:5.23|P-value:8.56E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.27|P-value:9.42E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.71|P-value:8.56E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.34|P-value:7.46E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.71|P-value:8.50E-6 ID:SGTC_263|Compound:alizarin|FD-Score:3.67|P-value:4.20E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:5.49|P-value:2.46E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.89|P-value:2.02E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.74|P-value:3.40E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.76|P-value:3.16E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:13.90|P-value:8.26E-38 ID:SGTC_660|Compound:4031-1742|FD-Score:4.20|P-value:6.59E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:3.65|P-value:4.52E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.92|P-value:1.78E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:6.37|P-value:2.50E-9 ID:SGTC_742|Compound:0kpi-0133|FD-Score:6.84|P-value:1.72E-10 ID:SGTC_1012|Compound:4112-3522|FD-Score:6.27|P-value:4.54E-9 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.40|P-value:6.07E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:7.76|P-value:5.01E-13 ID:SGTC_1132|Compound:3456-3614|FD-Score:7.12|P-value:3.05E-11 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.60|P-value:1.45E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.60|P-value:5.39E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.83|P-value:2.49E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.94|P-value:9.40E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.34|P-value:3.73E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.61|P-value:1.31E-5 ID:SGTC_1658|Compound:st012944|FD-Score:4.44|P-value:2.57E-5 ID:SGTC_1663|Compound:st014140|FD-Score:4.05|P-value:1.13E-4 ID:SGTC_1706|Compound:st031321|FD-Score:4.10|P-value:9.50E-5 ID:SGTC_1750|Compound:st081859|FD-Score:24.30|P-value:3.82E-112 ID:SGTC_1866|Compound:st057638|FD-Score:5.24|P-value:8.28E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.29|P-value:6.58E-7 ID:SGTC_2006|Compound:4011487|FD-Score:4.46|P-value:2.36E-5 ID:SGTC_2010|Compound:4012422|FD-Score:-3.61|P-value:3.00E-4 ID:SGTC_2066|Compound:5222451|FD-Score:5.44|P-value:3.25E-7 ID:SGTC_2074|Compound:5212007|FD-Score:-3.89|P-value:1.15E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.55|P-value:3.77E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.72|P-value:3.66E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.65|P-value:4.63E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.95|P-value:3.08E-6 ID:SGTC_2291|Compound:7917025|FD-Score:4.25|P-value:5.36E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.75|P-value:3.24E-4 ID:SGTC_2401|Compound:5128683|FD-Score:5.92|P-value:2.84E-8 ID:SGTC_2468|Compound:5987765|FD-Score:3.70|P-value:3.83E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.64|P-value:1.14E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.38|P-value:6.47E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.30|P-value:8.55E-4 ID:SGTC_2711|Compound:st079103|FD-Score:4.28|P-value:4.83E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.45|P-value:8.79E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.00|P-value:1.34E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.61|P-value:3.10E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.20|P-value:6.42E-5 ID:SGTC_2973|Compound:9094665|FD-Score:5.30|P-value:6.15E-7 ID:SGTC_2998|Compound:9066762|FD-Score:3.42|P-value:9.69E-4 ID:SGTC_3018|Compound:9082602|FD-Score:4.52|P-value:1.83E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.71|P-value:3.69E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.49|P-value:7.68E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.14|P-value:8.07E-5 ID:SGTC_3235|Compound:9132602|FD-Score:4.95|P-value:2.99E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-3.46|P-value:5.03E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.12|P-value:8.79E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.90|P-value:1.92E-4 ID:SGTC_3339|Compound:9145883|FD-Score:5.18|P-value:1.08E-6 ID:SGTC_8|Compound:0354-0001|FD-Score:5.02|P-value:2.22E-6 ID:SGTC_56|Compound:0957-0365|FD-Score:5.12|P-value:1.40E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.51|P-value:1.03E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:3.72|P-value:3.58E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:6.69|P-value:4.17E-10 ID:SGTC_91|Compound:0417-1751|FD-Score:3.98|P-value:1.46E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.61|P-value:1.29E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:5.23|P-value:8.56E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.27|P-value:9.42E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.71|P-value:8.56E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.34|P-value:7.46E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.71|P-value:8.50E-6 ID:SGTC_263|Compound:alizarin|FD-Score:3.67|P-value:4.20E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:5.49|P-value:2.46E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.89|P-value:2.02E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.74|P-value:3.40E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.76|P-value:3.16E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:13.90|P-value:8.26E-38 ID:SGTC_660|Compound:4031-1742|FD-Score:4.20|P-value:6.59E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:3.65|P-value:4.52E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.92|P-value:1.78E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:6.37|P-value:2.50E-9 ID:SGTC_742|Compound:0kpi-0133|FD-Score:6.84|P-value:1.72E-10 ID:SGTC_1012|Compound:4112-3522|FD-Score:6.27|P-value:4.54E-9 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.40|P-value:6.07E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:7.76|P-value:5.01E-13 ID:SGTC_1132|Compound:3456-3614|FD-Score:7.12|P-value:3.05E-11 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.60|P-value:1.45E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.60|P-value:5.39E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.83|P-value:2.49E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.94|P-value:9.40E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.34|P-value:3.73E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.61|P-value:1.31E-5 ID:SGTC_1658|Compound:st012944|FD-Score:4.44|P-value:2.57E-5 ID:SGTC_1663|Compound:st014140|FD-Score:4.05|P-value:1.13E-4 ID:SGTC_1706|Compound:st031321|FD-Score:4.10|P-value:9.50E-5 ID:SGTC_1750|Compound:st081859|FD-Score:24.30|P-value:3.82E-112 ID:SGTC_1866|Compound:st057638|FD-Score:5.24|P-value:8.28E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.29|P-value:6.58E-7 ID:SGTC_2006|Compound:4011487|FD-Score:4.46|P-value:2.36E-5 ID:SGTC_2010|Compound:4012422|FD-Score:-3.61|P-value:3.00E-4 ID:SGTC_2066|Compound:5222451|FD-Score:5.44|P-value:3.25E-7 ID:SGTC_2074|Compound:5212007|FD-Score:-3.89|P-value:1.15E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.55|P-value:3.77E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.72|P-value:3.66E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.65|P-value:4.63E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.95|P-value:3.08E-6 ID:SGTC_2291|Compound:7917025|FD-Score:4.25|P-value:5.36E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.75|P-value:3.24E-4 ID:SGTC_2401|Compound:5128683|FD-Score:5.92|P-value:2.84E-8 ID:SGTC_2468|Compound:5987765|FD-Score:3.70|P-value:3.83E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.64|P-value:1.14E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.38|P-value:6.47E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.30|P-value:8.55E-4 ID:SGTC_2711|Compound:st079103|FD-Score:4.28|P-value:4.83E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.45|P-value:8.79E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.00|P-value:1.34E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.61|P-value:3.10E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.20|P-value:6.42E-5 ID:SGTC_2973|Compound:9094665|FD-Score:5.30|P-value:6.15E-7 ID:SGTC_2998|Compound:9066762|FD-Score:3.42|P-value:9.69E-4 ID:SGTC_3018|Compound:9082602|FD-Score:4.52|P-value:1.83E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.71|P-value:3.69E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.49|P-value:7.68E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.14|P-value:8.07E-5 ID:SGTC_3235|Compound:9132602|FD-Score:4.95|P-value:2.99E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-3.46|P-value:5.03E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.12|P-value:8.79E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.90|P-value:1.92E-4 ID:SGTC_3339|Compound:9145883|FD-Score:5.18|P-value:1.08E-6

Top fitness defect scores for YKL098W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 24.30 2.4 µM 3.82E-112 endomembrane recycling 8 1.88E-130
2 SGTC_568 1193-0097 13.90 7.5 µM 8.26E-38 ERAD & cell cycle 6 5.61E-44
3 SGTC_1128 3448-9350 7.76 235.0 µM 5.01E-13 2 4.39E-15
4 SGTC_1132 3456-3614 7.12 2.5 µM 3.05E-11 tubulin folding & SWR complex 7 5.32E-13
5 SGTC_742 0kpi-0133 6.84 140.0 µM 1.72E-10 ERG2 4 4.03E-12
6 SGTC_87 0100-0052 6.69 35.5 µM 4.17E-10 22 1.13E-11
7 SGTC_736 0958-0254 6.37 92.6 µM 2.50E-9 Golgi 3 9.20E-11
8 SGTC_1012 4112-3522 6.27 18.0 µM 4.54E-9 3 1.84E-10
9 SGTC_2401 5128683 5.92 200.0 µM 2.84E-8 11 1.57E-9
10 SGTC_1161 k007-0610 5.60 110.0 µM 1.45E-7 ERAD & cell cycle 62 1.06E-8
11 SGTC_402 epigallocatechin gallate 5.49 10.0 µM 2.46E-7 3 1.96E-8
12 SGTC_2066 5222451 5.44 176.0 µM 3.25E-7 heme biosynthesis & mitochondrial translocase 12 2.72E-8
13 SGTC_2973 9094665 5.30 18.0 µM 6.15E-7 NEO1 8 5.73E-8
14 SGTC_1926 methyl fluorone black 5.29 53.6 µM 6.58E-7 DNA intercalators 29 6.21E-8
15 SGTC_1866 st057638 5.24 64.0 µM 8.28E-7 6 8.12E-8
16 SGTC_115 0527-0192 5.23 112.0 µM 8.56E-7 26 8.44E-8
17 SGTC_3339 9145883 5.18 14.9 µM 1.08E-6 4 1.11E-7
18 SGTC_56 0957-0365 5.12 83.2 µM 1.40E-6 Golgi 26 1.50E-7
19 SGTC_8 0354-0001 5.02 70.0 µM 2.22E-6 42 2.57E-7
20 SGTC_3235 9132602 4.95 49.5 µM 2.99E-6 10 3.65E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.558 4.12E-274 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.497 1.22E-208 YPR153W YPR153W hom Putative protein of unknown function
0.405 2.62E-132 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.388 8.41E-121 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.327 3.86E-84 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.314 2.09E-77 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.290 4.06E-66 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.262 1.19E-53 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.244 1.59E-46 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.239 6.44E-45 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.237 6.64E-44 YHR151C MTC6 hom Protein of unknown function; mtc6 is synthetically sick with cdc13-1
0.225 7.45E-40 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.222 7.93E-39 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.217 4.49E-37 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.206 2.05E-33 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C