YKL100C_p

Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL100C / YKL100C

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:2.81|P-value:7.61E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.90|P-value:5.65E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.56|P-value:3.00E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:4.19|P-value:1.18E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:3.03|P-value:3.21E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:2.80|P-value:7.89E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.18|P-value:1.68E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.07|P-value:2.71E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:2.81|P-value:7.60E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.60|P-value:2.63E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.51|P-value:3.73E-5 ID:SGTC_460|Compound:trequinsin|FD-Score:3.69|P-value:1.62E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:-3.02|P-value:3.47E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:2.95|P-value:4.44E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.98|P-value:3.86E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.21|P-value:1.56E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.02|P-value:3.31E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.41|P-value:6.05E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:-4.46|P-value:2.77E-7 ID:SGTC_1570|Compound:verbenone|FD-Score:2.78|P-value:8.44E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.52|P-value:3.64E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-2.96|P-value:4.45E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.64|P-value:2.00E-5 ID:SGTC_1795|Compound:st049545|FD-Score:2.94|P-value:4.52E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.46|P-value:4.76E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.14|P-value:2.01E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-2.90|P-value:5.66E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.24|P-value:1.32E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:-2.79|P-value:8.80E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.00|P-value:3.60E-4 ID:SGTC_2967|Compound:9089538|FD-Score:2.92|P-value:4.95E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.40|P-value:6.70E-5 ID:SGTC_3202|Compound:9113761|FD-Score:4.26|P-value:7.89E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-3.15|P-value:2.05E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-2.96|P-value:4.51E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.54|P-value:3.25E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.64|P-value:2.02E-5 ID:SGTC_3332|Compound:9141069|FD-Score:3.60|P-value:2.53E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.38|P-value:6.88E-5 ID:SGTC_3339|Compound:9145883|FD-Score:2.89|P-value:5.65E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:2.81|P-value:7.61E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.90|P-value:5.65E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.56|P-value:3.00E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:4.19|P-value:1.18E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:3.03|P-value:3.21E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:2.80|P-value:7.89E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.18|P-value:1.68E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.07|P-value:2.71E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:2.81|P-value:7.60E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.60|P-value:2.63E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.51|P-value:3.73E-5 ID:SGTC_460|Compound:trequinsin|FD-Score:3.69|P-value:1.62E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:-3.02|P-value:3.47E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:2.95|P-value:4.44E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.98|P-value:3.86E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.21|P-value:1.56E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.02|P-value:3.31E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.41|P-value:6.05E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:-4.46|P-value:2.77E-7 ID:SGTC_1570|Compound:verbenone|FD-Score:2.78|P-value:8.44E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.52|P-value:3.64E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-2.96|P-value:4.45E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.64|P-value:2.00E-5 ID:SGTC_1795|Compound:st049545|FD-Score:2.94|P-value:4.52E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.46|P-value:4.76E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.14|P-value:2.01E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-2.90|P-value:5.66E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.24|P-value:1.32E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:-2.79|P-value:8.80E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.00|P-value:3.60E-4 ID:SGTC_2967|Compound:9089538|FD-Score:2.92|P-value:4.95E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.40|P-value:6.70E-5 ID:SGTC_3202|Compound:9113761|FD-Score:4.26|P-value:7.89E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-3.15|P-value:2.05E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-2.96|P-value:4.51E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.54|P-value:3.25E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.64|P-value:2.02E-5 ID:SGTC_3332|Compound:9141069|FD-Score:3.60|P-value:2.53E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.38|P-value:6.88E-5 ID:SGTC_3339|Compound:9145883|FD-Score:2.89|P-value:5.65E-4

Top fitness defect scores for YKL100C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3202 9113761 4.26 49.5 µM 7.89E-7 36 1.02E-5
2 SGTC_39 0986-0283 4.19 58.4 µM 1.18E-6 calcium & mitochondrial duress 32 1.40E-5
3 SGTC_460 trequinsin 3.69 123.0 µM 1.62E-5 5 1.13E-4
4 SGTC_1739 st037196 3.64 92.5 µM 2.00E-5 32 1.34E-4
5 SGTC_3315 9136395 3.64 68.5 µM 2.02E-5 13 1.35E-4
6 SGTC_3332 9141069 3.60 11.2 µM 2.53E-5 26 1.62E-4
7 SGTC_38 0929-0051 3.56 58.3 µM 3.00E-5 30 1.85E-4
8 SGTC_3314 9135860 3.54 59.4 µM 3.25E-5 28 1.98E-4
9 SGTC_1589 2',5'-dimethoxyflavone 3.52 47.2 µM 3.64E-5 33 2.16E-4
10 SGTC_455 paf C-16 3.51 10.0 µM 3.73E-5 43 2.21E-4
11 SGTC_1979 st071809 3.46 45.3 µM 4.76E-5 RPP1 & pyrimidine depletion 28 2.68E-4
12 SGTC_1372 2752-0194 3.41 270.0 µM 6.05E-5 31 3.25E-4
13 SGTC_3336 9143619 3.38 71.4 µM 6.88E-5 36 3.60E-4
14 SGTC_2476 5806916 3.24 10.5 µM 1.32E-4 33 6.04E-4
15 SGTC_112 phenothiazine 3.18 287.2 µM 1.68E-4 unfolded protein response 31 7.35E-4
16 SGTC_2065 5221596 3.14 34.3 µM 2.01E-4 43 8.50E-4
17 SGTC_116 0155-0182 3.07 31.8 µM 2.71E-4 mitochondrial response to ROS 157 0.00108
18 SGTC_41 0478-0632 3.03 82.6 µM 3.21E-4 74 0.00123
19 SGTC_1293 1000-1278 3.02 195.0 µM 3.31E-4 56 0.00127
20 SGTC_2933 9026794 3.00 32.5 µM 3.60E-4 78 0.00135

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 5.11E-20 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.152 6.37E-19 YKL174C TPO5 hom Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
0.151 1.69E-18 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.148 6.53E-18 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.145 2.99E-17 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.142 1.53E-16 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.141 2.75E-16 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.140 3.13E-16 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.140 3.05E-16 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.135 3.54E-15 YKL006C-A SFT1 het Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
0.133 9.95E-15 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.132 2.10E-14 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.129 6.75E-14 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.126 2.25E-13 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.125 4.26E-13 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data