YKL101W / HSL1

Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL101W / HSL1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.89|P-value:7.47E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.37|P-value:5.06E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.70|P-value:1.54E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.28|P-value:1.29E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:3.26|P-value:7.36E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:4.36|P-value:1.06E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:4.04|P-value:3.95E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.40|P-value:4.48E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.34|P-value:5.61E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.94|P-value:6.11E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:3.71|P-value:1.49E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:4.03|P-value:4.21E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.22|P-value:8.43E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.22|P-value:1.89E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:3.52|P-value:3.00E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:4.52|P-value:5.14E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:4.62|P-value:3.28E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.53|P-value:2.85E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.22|P-value:8.38E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.26|P-value:7.38E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.37|P-value:5.05E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:5.32|P-value:1.00E-7 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.68|P-value:1.67E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.56|P-value:4.16E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.35|P-value:1.07E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.58|P-value:2.42E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.55|P-value:4.35E-6 ID:SGTC_1798|Compound:st045719|FD-Score:4.14|P-value:2.68E-5 ID:SGTC_1821|Compound:st053465|FD-Score:4.80|P-value:1.35E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.24|P-value:7.92E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.61|P-value:3.42E-6 ID:SGTC_1923|Compound:st058458|FD-Score:3.30|P-value:6.37E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.27|P-value:1.51E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.39|P-value:4.69E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.18|P-value:9.69E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.89|P-value:7.30E-5 ID:SGTC_2102|Compound:5377816|FD-Score:4.27|P-value:1.56E-5 ID:SGTC_2205|Compound:7238770|FD-Score:3.36|P-value:5.24E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.35|P-value:5.51E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.26|P-value:1.62E-5 ID:SGTC_2396|Compound:5342950|FD-Score:6.90|P-value:7.74E-12 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.67|P-value:2.53E-6 ID:SGTC_2428|Compound:5615643|FD-Score:6.93|P-value:6.03E-12 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.31|P-value:6.21E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.10|P-value:2.78E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.23|P-value:8.19E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.95|P-value:6.59E-7 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.10|P-value:3.19E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:4.62|P-value:3.17E-6 ID:SGTC_2885|Compound:9057732|FD-Score:4.34|P-value:1.13E-5 ID:SGTC_3031|Compound:9088762|FD-Score:3.37|P-value:5.14E-4 ID:SGTC_3035|Compound:9091303|FD-Score:4.88|P-value:9.32E-7 ID:SGTC_3126|Compound:9127922|FD-Score:-3.23|P-value:7.38E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.29|P-value:5.94E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.54|P-value:2.50E-4 ID:SGTC_3235|Compound:9132602|FD-Score:5.24|P-value:1.57E-7 ID:SGTC_3247|Compound:9135149|FD-Score:3.84|P-value:8.89E-5 ID:SGTC_3255|Compound:9139072|FD-Score:4.20|P-value:2.02E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.43|P-value:4.08E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.89|P-value:7.47E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.37|P-value:5.06E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.70|P-value:1.54E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.28|P-value:1.29E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:3.26|P-value:7.36E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:4.36|P-value:1.06E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:4.04|P-value:3.95E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.40|P-value:4.48E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.34|P-value:5.61E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.94|P-value:6.11E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:3.71|P-value:1.49E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:4.03|P-value:4.21E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.22|P-value:8.43E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.22|P-value:1.89E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:3.52|P-value:3.00E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:4.52|P-value:5.14E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:4.62|P-value:3.28E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.53|P-value:2.85E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.22|P-value:8.38E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.26|P-value:7.38E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.37|P-value:5.05E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:5.32|P-value:1.00E-7 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.68|P-value:1.67E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.56|P-value:4.16E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.35|P-value:1.07E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.58|P-value:2.42E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.55|P-value:4.35E-6 ID:SGTC_1798|Compound:st045719|FD-Score:4.14|P-value:2.68E-5 ID:SGTC_1821|Compound:st053465|FD-Score:4.80|P-value:1.35E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.24|P-value:7.92E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.61|P-value:3.42E-6 ID:SGTC_1923|Compound:st058458|FD-Score:3.30|P-value:6.37E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.27|P-value:1.51E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.39|P-value:4.69E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.18|P-value:9.69E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.89|P-value:7.30E-5 ID:SGTC_2102|Compound:5377816|FD-Score:4.27|P-value:1.56E-5 ID:SGTC_2205|Compound:7238770|FD-Score:3.36|P-value:5.24E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.35|P-value:5.51E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.26|P-value:1.62E-5 ID:SGTC_2396|Compound:5342950|FD-Score:6.90|P-value:7.74E-12 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.67|P-value:2.53E-6 ID:SGTC_2428|Compound:5615643|FD-Score:6.93|P-value:6.03E-12 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.31|P-value:6.21E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.10|P-value:2.78E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.23|P-value:8.19E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.95|P-value:6.59E-7 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.10|P-value:3.19E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:4.62|P-value:3.17E-6 ID:SGTC_2885|Compound:9057732|FD-Score:4.34|P-value:1.13E-5 ID:SGTC_3031|Compound:9088762|FD-Score:3.37|P-value:5.14E-4 ID:SGTC_3035|Compound:9091303|FD-Score:4.88|P-value:9.32E-7 ID:SGTC_3126|Compound:9127922|FD-Score:-3.23|P-value:7.38E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.29|P-value:5.94E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.54|P-value:2.50E-4 ID:SGTC_3235|Compound:9132602|FD-Score:5.24|P-value:1.57E-7 ID:SGTC_3247|Compound:9135149|FD-Score:3.84|P-value:8.89E-5 ID:SGTC_3255|Compound:9139072|FD-Score:4.20|P-value:2.02E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.43|P-value:4.08E-4

Top fitness defect scores for YKL101W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2428 5615643 6.93 7.8 µM 6.03E-12 5 2.03E-12
2 SGTC_2396 5342950 6.90 42.8 µM 7.74E-12 RSC complex & mRNA processing 10 2.64E-12
3 SGTC_1392 3455-1037 5.32 33.9 µM 1.00E-7 4 5.16E-8
4 SGTC_3235 9132602 5.24 49.5 µM 1.57E-7 8 8.20E-8
5 SGTC_2759 disulfiram 4.95 3.4 µM 6.59E-7 13 3.67E-7
6 SGTC_3035 9091303 4.88 49.5 µM 9.32E-7 1 5.27E-7
7 SGTC_1821 st053465 4.80 65.6 µM 1.35E-6 3 7.78E-7
8 SGTC_2405 ticlatone 4.67 3.5 µM 2.53E-6 43 1.49E-6
9 SGTC_2777 climbazole 4.62 1.5 µM 3.17E-6 iron homeostasis 26 1.89E-6
10 SGTC_910 3454-3003 4.62 490.0 µM 3.28E-6 8 1.96E-6
11 SGTC_1909 st060837 4.61 51.5 µM 3.42E-6 35 2.05E-6
12 SGTC_1459 k035-0031 4.56 35.7 µM 4.16E-6 DNA intercalators 13 2.51E-6
13 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 4.55 19.1 µM 4.35E-6 14 2.64E-6
14 SGTC_903 1134-0042 4.52 114.0 µM 5.14E-6 14 3.13E-6
15 SGTC_380 3970-0968 4.36 6.0 µM 1.06E-5 8 6.65E-6
16 SGTC_1482 3346-2049 4.35 8.5 µM 1.07E-5 24 6.76E-6
17 SGTC_2885 9057732 4.34 52.0 µM 1.13E-5 10 7.15E-6
18 SGTC_1959 st077091 4.27 55.8 µM 1.51E-5 RPP1 & pyrimidine depletion 37 9.63E-6
19 SGTC_2102 5377816 4.27 72.8 µM 1.56E-5 18 9.98E-6
20 SGTC_2340 7987427 4.26 183.4 µM 1.62E-5 23 1.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 7.43E-30 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.134 7.72E-15 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.133 1.27E-14 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.129 6.18E-14 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.126 2.87E-13 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.119 4.39E-12 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.118 5.92E-12 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.109 2.49E-10 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.107 4.98E-10 YOR256C TRE2 het Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication
0.107 6.06E-10 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.106 6.87E-10 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.105 1.08E-9 YJL182C_d YJL182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W
0.104 1.45E-9 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.100 5.86E-9 YER022W SRB4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
0.095 3.84E-8 YIL106W MOB1 het Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress