YKL106W / AAT1

Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL106W / AAT1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.43|P-value:1.02E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:4.85|P-value:1.00E-7 ID:SGTC_266|Compound:formosanin C|FD-Score:2.94|P-value:8.07E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:2.99|P-value:6.52E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.13|P-value:3.95E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.08|P-value:4.66E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.12|P-value:3.98E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.42|P-value:1.18E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:2.88|P-value:9.99E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:2.88|P-value:9.93E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.18|P-value:3.17E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:4.11|P-value:5.09E-6 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.83|P-value:1.96E-5 ID:SGTC_1620|Compound:st003704|FD-Score:3.61|P-value:5.44E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.99|P-value:9.43E-6 ID:SGTC_1635|Compound:st007035|FD-Score:8.19|P-value:8.42E-19 ID:SGTC_1674|Compound:st016616|FD-Score:4.74|P-value:1.85E-7 ID:SGTC_1868|Compound:st057644|FD-Score:3.07|P-value:4.83E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.51|P-value:8.61E-5 ID:SGTC_1982|Compound:st072467|FD-Score:4.47|P-value:8.20E-7 ID:SGTC_2282|Compound:7944268|FD-Score:4.20|P-value:3.24E-6 ID:SGTC_2286|Compound:7945697|FD-Score:4.95|P-value:5.49E-8 ID:SGTC_2292|Compound:7671323|FD-Score:-3.22|P-value:2.84E-4 ID:SGTC_2295|Compound:7971645|FD-Score:5.92|P-value:1.10E-10 ID:SGTC_2323|Compound:6148992|FD-Score:-3.35|P-value:1.73E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.29|P-value:2.06E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.97|P-value:7.15E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.43|P-value:1.18E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.06|P-value:5.08E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.16|P-value:3.62E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.00|P-value:6.49E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.27|P-value:2.28E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.45|P-value:1.14E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.86|P-value:1.70E-5 ID:SGTC_2846|Compound:9008642|FD-Score:2.99|P-value:6.75E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.06|P-value:5.33E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.72|P-value:3.41E-5 ID:SGTC_2888|Compound:9058547|FD-Score:8.62|P-value:1.22E-20 ID:SGTC_2891|Compound:9063876|FD-Score:5.59|P-value:1.03E-9 ID:SGTC_3027|Compound:9089541|FD-Score:2.98|P-value:6.85E-4 ID:SGTC_3039|Compound:9090270|FD-Score:4.91|P-value:7.06E-8 ID:SGTC_3062|Compound:9077494|FD-Score:3.13|P-value:3.96E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.04|P-value:5.45E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.17|P-value:3.48E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.43|P-value:1.02E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:4.85|P-value:1.00E-7 ID:SGTC_266|Compound:formosanin C|FD-Score:2.94|P-value:8.07E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:2.99|P-value:6.52E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.13|P-value:3.95E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.08|P-value:4.66E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.12|P-value:3.98E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.42|P-value:1.18E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:2.88|P-value:9.99E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:2.88|P-value:9.93E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.18|P-value:3.17E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:4.11|P-value:5.09E-6 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.83|P-value:1.96E-5 ID:SGTC_1620|Compound:st003704|FD-Score:3.61|P-value:5.44E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.99|P-value:9.43E-6 ID:SGTC_1635|Compound:st007035|FD-Score:8.19|P-value:8.42E-19 ID:SGTC_1674|Compound:st016616|FD-Score:4.74|P-value:1.85E-7 ID:SGTC_1868|Compound:st057644|FD-Score:3.07|P-value:4.83E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.51|P-value:8.61E-5 ID:SGTC_1982|Compound:st072467|FD-Score:4.47|P-value:8.20E-7 ID:SGTC_2282|Compound:7944268|FD-Score:4.20|P-value:3.24E-6 ID:SGTC_2286|Compound:7945697|FD-Score:4.95|P-value:5.49E-8 ID:SGTC_2292|Compound:7671323|FD-Score:-3.22|P-value:2.84E-4 ID:SGTC_2295|Compound:7971645|FD-Score:5.92|P-value:1.10E-10 ID:SGTC_2323|Compound:6148992|FD-Score:-3.35|P-value:1.73E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.29|P-value:2.06E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.97|P-value:7.15E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.43|P-value:1.18E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.06|P-value:5.08E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.16|P-value:3.62E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.00|P-value:6.49E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.27|P-value:2.28E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.45|P-value:1.14E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.86|P-value:1.70E-5 ID:SGTC_2846|Compound:9008642|FD-Score:2.99|P-value:6.75E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.06|P-value:5.33E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.72|P-value:3.41E-5 ID:SGTC_2888|Compound:9058547|FD-Score:8.62|P-value:1.22E-20 ID:SGTC_2891|Compound:9063876|FD-Score:5.59|P-value:1.03E-9 ID:SGTC_3027|Compound:9089541|FD-Score:2.98|P-value:6.85E-4 ID:SGTC_3039|Compound:9090270|FD-Score:4.91|P-value:7.06E-8 ID:SGTC_3062|Compound:9077494|FD-Score:3.13|P-value:3.96E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.04|P-value:5.45E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.17|P-value:3.48E-4

Top fitness defect scores for YKL106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2888 9058547 8.62 13.0 µM 1.22E-20 1 3.36E-18
2 SGTC_1635 st007035 8.19 42.4 µM 8.42E-19 95 1.35E-16
3 SGTC_2295 7971645 5.92 200.0 µM 1.10E-10 5 1.63E-9
4 SGTC_2891 9063876 5.59 19.5 µM 1.03E-9 1 1.15E-8
5 SGTC_2286 7945697 4.95 125.0 µM 5.49E-8 28 3.71E-7
6 SGTC_3039 9090270 4.91 49.5 µM 7.06E-8 RPP1 & pyrimidine depletion 5 4.63E-7
7 SGTC_236 1509-0011 4.85 5.3 µM 1.00E-7 332 6.28E-7
8 SGTC_1674 st016616 4.74 23.6 µM 1.85E-7 12 1.07E-6
9 SGTC_1982 st072467 4.47 71.9 µM 8.20E-7 25 3.95E-6
10 SGTC_65 0798-0905 4.43 35.0 µM 1.02E-6 calcium & mitochondrial duress 65 4.80E-6
11 SGTC_2282 7944268 4.20 200.0 µM 3.24E-6 RPP1 & pyrimidine depletion 24 1.31E-5
12 SGTC_1295 1013-0063 4.11 9.8 µM 5.09E-6 7 1.95E-5
13 SGTC_1628 st004252 3.99 77.7 µM 9.43E-6 21 3.35E-5
14 SGTC_2837 9008476 3.86 45.5 µM 1.70E-5 39 5.62E-5
15 SGTC_1308 1187-1617 3.83 41.4 µM 1.96E-5 fatty acid desaturase (OLE1) 45 6.36E-5
16 SGTC_1620 st003704 3.61 16.5 µM 5.44E-5 27 1.55E-4
17 SGTC_2405 ticlatone 3.44 3.5 µM 1.09E-4 90 2.86E-4
18 SGTC_2376 9072922 3.43 81.3 µM 1.18E-4 52 3.07E-4
19 SGTC_861 0443-0273 3.42 110.0 µM 1.18E-4 25 3.08E-4
20 SGTC_2339 9000433 3.29 200.0 µM 2.06E-4 59 4.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.317 2.25E-79 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.308 1.09E-74 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.299 3.12E-70 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.299 3.27E-70 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.293 3.04E-67 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.291 1.41E-66 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.291 2.34E-66 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.279 4.07E-61 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.271 2.10E-57 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.269 1.64E-56 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.265 6.72E-55 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.259 1.70E-52 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.251 2.13E-49 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.248 2.08E-48 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.248 3.82E-48 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex