HIPHOP chemogenomics database
YKL107W_p 
Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKL107W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.106 | 7.91E-10 | YPL160W | CDC60 | het | Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA |
| 0.091 | 1.43E-7 | YOL022C | TSR4 | het | Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2 |
| 0.086 | 5.95E-7 | YDR033W | MRH1 | hom | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication |
| 0.083 | 1.68E-6 | YPL108W_p | YPL108W_p | hom | Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS |
| 0.078 | 5.47E-6 | YJL057C | IKS1 | hom | Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p |
| 0.077 | 7.01E-6 | YHR139C-A_d | YHR139C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.077 | 7.64E-6 | YER134C | YER134C | hom | Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene |
| 0.077 | 8.06E-6 | YDL224C | WHI4 | hom | Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication |
| 0.076 | 1.04E-5 | YHR018C | ARG4 | hom | Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway |
| 0.074 | 1.79E-5 | YOR321W | PMT3 | hom | Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication |
| 0.071 | 3.98E-5 | YML006C | GIS4 | hom | CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway |
| 0.070 | 4.93E-5 | YMR003W | AIM34 | hom | Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss |
| 0.069 | 7.06E-5 | YOR059C | YOR059C | hom | Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress |
| 0.068 | 7.19E-5 | YDR459C | PFA5 | hom | Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain |
| 0.068 | 7.23E-5 | YDL008W | APC11 | het | Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity |